Disease Information for Central Hypotonia Infants

demyelination classically but syndrome as well with many causes.Congenital hypotonia is a relatively common diagnosis in the newborn period. It is defined as a subjective decrease of resistance to passive range of motion in a newborn and can be due to a defect at any level of the nervous system. ADHB.GOV/NZ NOTES online 2008].

The frequency of various disorders causing neonatal hypotonia and the reliability of the first physical examination and standard diagnostic tests were evaluated by a review of medical records of patients diagnosed between 1999 and 2005 at Strasbourg University Hospital, France. Patients were only eligible for inclusion if hypotonia had first been noticed before the 28th day of life and had lasted for at least two weeks. Exclusion criteria were gestational age less than 35 weeks and obvious extra-neurological diagnosis (eg, neonatal infection and congenital heart failure). Initial presentation of hypotonia was classified as central, peripheral, or undetermined, according to the following criteria: infants with central hypotonic cases had preserved antigravity limb movements; normal or increased peripheral tone; poor visual contact; seizures; and brisk tendon reflexes. Peripheral hypotonia was characterized by muscular weakness, absent antigravity movements, decreased reflexes, global hypotonia, and preserved social interaction.

[millichap md neurology 2008/seen on online 2008]

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