Disease Information for Central Hypotonia Infants

Clinical Manifestations
Signs & Symptoms
Hyperextensable Joints Infant
Tongue Protrudes Infant
Central hypotonia, infants
Delay Sitting Unsupported Infant
Head Lag Infant Sign
Mouth Hangs Open Infant
Muscle weakness
Muscles Soft/Doughy Infant
Neck weakness/head nodding
Rolling Over Delay Infant
Babkin infant sign/Abnormal
Delayed walking milestone/child
Development Motor Skills (Milestones) Delayed
Galant Infant reflex/Abnormal
Head Neck Floppy Infant Hypotonia Sign
Infant Head Support Delay
Moro reflex Poor/Absent Infant
Neurologic manifestations/signs
Palmar Grasp infant Reflex Abnormal
Primitive infant reflexes/Abnormal
Rooting infant sign/Abnormal
Swimming infant reflex/Abnormal
Tonic Neck Infant reflex/Abnormal
Truncal hypotonia
Shallow Breathing Infant
Demographics & Risk Factors
Population Group
Population/Pediatrics population
Sex & Age Groups
Associated Diseases & Rule outs
Associated Disease & Complications
Neonatal Hypotonia/Floppy Baby Syndrome
Disease Mechanism & Classification
CLASS/Pediatric disorders (ex)
CLASS/Muscle disorder (ex)
CLASS/Muscle involvement/manifestations
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)

demyelination classically but syndrome as well with many causes.Congenital hypotonia is a relatively common diagnosis in the newborn period. It is defined as a subjective decrease of resistance to passive range of motion in a newborn and can be due to a defect at any level of the nervous system. ADHB.GOV/NZ NOTES online 2008].

The frequency of various disorders causing neonatal hypotonia and the reliability of the first physical examination and standard diagnostic tests were evaluated by a review of medical records of patients diagnosed between 1999 and 2005 at Strasbourg University Hospital, France. Patients were only eligible for inclusion if hypotonia had first been noticed before the 28th day of life and had lasted for at least two weeks. Exclusion criteria were gestational age less than 35 weeks and obvious extra-neurological diagnosis (eg, neonatal infection and congenital heart failure). Initial presentation of hypotonia was classified as central, peripheral, or undetermined, according to the following criteria: infants with central hypotonic cases had preserved antigravity limb movements; normal or increased peripheral tone; poor visual contact; seizures; and brisk tendon reflexes. Peripheral hypotonia was characterized by muscular weakness, absent antigravity movements, decreased reflexes, global hypotonia, and preserved social interaction.

[millichap md neurology 2008/seen on online 2008]



External Links Related to Central Hypotonia Infants
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)