Disease Information for Central diabetes insipidus

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Clinical Manifestations
Signs & Symptoms
Excessive thirst/polydipsia
Bed wetting
Diuresis/Large urine volumes
Polyuria
Polyuria and polydipsia
Urine Frequency
Thirst Increased
Laboratory Tests
Abnormal Lab Findings (Non Measured)
URINE Isosthenuria/mid-range SPGR
URINE Specific gravity fixed/1.010
Abnormal Lab Findings - Decreased
ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)
Abnormal Lab Findings - Increased
Sodium, serum (Lab)
Diagnostic Test Results
CT Scan
MRI/Head Absent bright spot posterior pituitary (T1 weighted)
MRI/Head Brain Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Central diabetes insipidus
Diabetes insipidus
Eneuresis Bed Wetting
Enuresis, functional
Hypernatremia
Isosthenuria syndrome
Disease Mechanism & Classification
Class
CLASS/Endocrine gland (category)
Pathophysiology
Pathophysiology/Blood volume/decrease/low
Pathophysiology/Renal concentration capacity defect
Process
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Definition

Deficiency of vasopressin secretion from the posterior pituitary gland. Clinical manifestations include extreme thirst, polydipsia, and reduced serum osmolality. Potential etiologies include CRANIOCEREBRAL TRAUMA; post-neurosurgical states; HYPOTHALAMIC NEOPLASMS; PITUITARY NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; PITUITARY APOPLEXY; CEREBROVASCULAR DISORDERS; granulomatous diseases (including SARCOIDOSIS); and other conditions. The disorder may also be inherited as an autosomal or recessive trait. (From Joynt, Clinical Neurology, 1992, Ch 36, pp55-8)

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External Links Related to Central diabetes insipidus
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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