Disease Information for Cataplexy

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Clinical Manifestations
Signs & Symptoms
Cataplexy-like attacks
Drop attacks
Startle response/trigger
Disease Progression
Course/Paroxysmal
Demographics & Risk Factors
Ethnic or Racial Factors
French-canadian ethnic stock
Laboratory Tests
Abnormal Lab Findings (Non Measured)
CSF Hypocretin 1 deficient
HLA DQB10602 (LAB)
Associated Diseases & Rule outs
Rule Outs
Epilepsy
Associated Disease & Complications
Cataplexy
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Hereditary disease/Adult manifestations
Pathophysiology/Abnormal hypocretin CNS pathways
Pathophysiology/Dysomnia/hypersomnias (ex)
Pathophysiology/Hypocretin 1 cell defect hypothalamus
Pathophysiology/Narcoleptic tetrad/NAR/CAT/SP/HH
Process
PROCESS/Vegetative-Autonomic/Endocrine (category)
Treatment
Drug Therapy - Indication
RX/Antidepressant medication
RX/Sodium oxybate (cataplexy)
RX/Xyrem (GHB/Gamma hydroxybutrate)
Definition

A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataleptic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)

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External Links Related to Cataplexy
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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