Disease Information for Catamenial/Progesterone Anaphylaxis

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Demographics & Risk Factors
Sex & Age Groups
Population/Female
Associated Diseases & Rule outs
Rule Outs
Anaphylaxis, generalized
Angioedema/angioneurotic edema
Associated Disease & Complications
Anaphylactoid reaction/Non-IGE/Very first dose
Anaphylaxis, generalized
Angioedema/angioneurotic edema
Drug Induced Infusion Reaction
Disease Mechanism & Classification
Class
CLASS/Immune System Disorder (ex)
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Immune system disorder (ex)
PROCESS/Immune/antibody-antigen system dis. (ex)
Synonyms
Synonym
Synonym/Idiopathic Anaphylaxis Syndrome
Treatment
Drug Therapy - Indication
RX/LHRH Analog Agonist Drug
RX/Montelukast (Singulair)
Definition

An idiopathic, little understood, anaphylaxis usually occurring in females before menses. Treated the same as other anaphylaxis effectively in an attack. Thought to relate to sensitization to progesterone but may relate to humoral cascades and hereditary factors. Steroids have helped but are not good for long term prevention. Skin testing with progesterone is sometimes positive for wheal and flare response but can be dangerous. It is not recommended. Both H1 and H2 antihistamines are used together as well. LHRH analog drugs for inducing temporary menopause have been successful. Montelukast is suggested by Dr Michael A Kaliner at the Institute for Asthma and Allergy; he is one of the early investigators of this syndrome at NIH.

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External Links Related to Catamenial/Progesterone Anaphylaxis
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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