Disease Information for Castleman's disease

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Clinical Manifestations
Signs & Symptoms
Acute Chest Pain in Children
Chest Pain in Children
Lymphadenopathy
Lymphadenopathy Systemic
Hepatosplenomegaly
Palpable Liver/Hepatomegaly
Splenomegaly
Constitutional symptoms
Debilitated
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Malaise
Clinical Presentation & Variations
Presentation/Refractory iron deficiency anemia
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Lethal possible/not usual
Course/Severe illness
Laboratory Tests
Microbiology & Serology Findings
Microlab/Herpesvirus 8 HHV8/KSHV
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Decreased
Hematocrit (Lab)
Hemoglobin (Lab)
Platelet count (Lab)
RBC/Red Blood Count (Lab)
Diagnostic Test Results
Pathology
BX/Lymph node biopsy/abnormal
BX/Lymph node/Plasmacyte infiltr/preserved architecture
Associated Diseases & Rule outs
Associated Disease & Complications
Anemia
Castleman's disease
Eaton-Lambert syndrome
Hyperglobulinemia
Thrombocytopenia
Disease Mechanism & Classification
Class
CLASS/Immune System Disorder (ex)
CLASS/Lymph node involvement/disorder (ex)
CLASS/Lymphocyte disorder (ex)
CLASS/Spleen/thymus/RES/immune system (category)
Pathophysiology
Pathophysiology/Hypertrophy/hyperplasia effect
Pathophysiology/Interleukin-6 (IL-6) excess/deregulated
Process
PROCESS/Neoplastic (category)
PROCESS/B-Cell neoplasm (ex)
PROCESS/Lymphoproliferative disorder (ex)
PROCESS/Immune system disorder (ex)
Treatment
Drug Therapy - Indication
RX/Tocilizumab (Actemra)
Definition

A rare disorder in which noncancerous growths develop in lymph node tissue.--------------------------------------------Castleman"s disease;Castleman"s angiofollicular hyperplasia; Castleman"s lymphadenopathy; Castleman"s tumor;

Angiofollicular lymph node hyperplasia; benign giant lymph node hyperplasia; benign lymphoid hyperplasia; giant lymph node hyperplasia; giant lymphoid hyperplasia of the mediastinum; lymphoid angio-follicular hyperplasia;

A pathological condition characterized by large, benign, hyperplastic lymph nodes containing concentric perivascular aggregates of lymphocytes-----[whonamedit_com 2005]----------

Castleman"s Disease; Angiofollicular Lymph Node Hyperplasia

Angiomatous Lymphoid; Castleman Tumor;Giant Benign Lymphoma;

Giant Lymph Node Hyperplasia; Hamartoma of the Lymphatics;

Castleman"s disease is a rare disorder characterized by non-cancerous (benign) growths (tumors) that may develop in the lymph node tissue throughout the body (ie, systemic disease [plasma cell type]); Most often, they occur in the chest, stomach, and/or neck (ie, localized disease [hyaline-vascular type]); Less common sites include the armpit (axilla), pelvis, and pancreas; Usually the growths represent abnormal enlargement of the lymph nodes normally found in these areas (lymphoid hamartoma); There are two main types of Castleman"s disease: hyaline-vascular type and plasma cell type; The hyaline vascular type accounts for approximately 90 percent of the cases; Most individuals exhibit no symptoms of this form of the disorder (asymptomatic) or they may develop non-cancerous growths in the lymph nodes; The plasma cell type of Castleman"s disease may be associated with fever, weight loss, skin rash, early destruction of red blood cells, leading to unusually low levels of circulating red blood cells (hemolytic anemia), and/or abnormally increased amounts of certain immune factors in the blood (hypergammaglobulinemia); A third type of Castleman"s disease has been reported in the medical literature; This type may affect more than one area of the body (multicentric or generalized Castleman"s disease); Many individuals with Multicentric Castleman"s disease may exhibit an abnormally large liver and spleen (hepatosplenomegaly); Researchers" opinions in the medical literature differ as to whether Multicentric Castleman"s disease is a distinct entity or a multicentric form of the plasma cell type of Castleman"s disease-----------[NORD 2005]---------

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External Links Related to Castleman's disease
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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