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Disease Information for Carboplatin (Paraplatin) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Baldness/Alopecia

Hair loss

Non-scarring Alopecia/balding

Rash

Laboratory Tests

Abnormal Lab Findings - Increased

Platelet count (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Agranulocytosis

Anaphylactoid reaction/Non-IGE/Very first dose

Bone marrow failure/exhaustion

Carboplatin (Paraplatin) toxicity

Dermatitis/Chronic rash

Drug induced Baldness/Alopecia

Drug induced Myelosuppression.

Drug induced Neutropenia.

Drug induced Peripheral neuropathy.

Drug induced Rash/eruption/herbal

Drug induced Thrombocytopenia.

Drug rash/Drug induced rash

Fetal anomaly

Granulocytopenia/Neutropenia

Myelosuppression

Peripheral neuropathy

Disease Mechanism & Classification

Drugs

DRUG/Alkylating agents (example)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Cytotoxic/chemotherapy medication (example)

DRUG/Platinum Chemotherapy agents

DRUG/Teratogenic potential/effect (D plus )

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

(SP 4 2) diammine(1,1 cyclobutanedicarboxylato(2 ) O,O')platinum, 1,1 cyclobutanedicarboxylic acid platinum complex, Carboplatin, Carboplatin (product), Carboplatin (substance), CARBOPLATIN PREPARATION, Carboplatino, CBDCA, CBDCA Carboplatin, cis diammine(1,1 cyclobutanedicarboxylato) platinum(II), Cis Diammine(cyclobutane 1,1 dicarboxylato)platinum, cis diammine(cyclobutanedicarboxylato)platinum II, DIAMMINECYCLOBUTANEDICARBOXYLATOPLATINUM II, platinum diammine(1,1 cyclobutanedicarboxylato(2 )) (SP 4 2), Brand name/Paraplatin (Carboplatin), Synonym/GemCarbo Chemotheray

Treatment

Drug Dosage

DRUG/Dose special schedule/course

DRUG/Dose Unit dose Vial preparation

DRUG/Injectable medication (parenteral)

DRUG/Intravenous administraton RX

Definition

Platinum toxic effect drug. Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell devision. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

(Edit)

External Links Related to Carboplatin (Paraplatin) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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