Disease Information for Busulfan (Myleran) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Breast Swelling Bilateral
Oral pigmentation lesions
Laboratory Tests
Abnormal Lab Findings - Decreased
Neutrophiles (Lab)
Diagnostic Test Results
Isotope Scan
Isotope/Gallium 67 lung scan abnormal
X-RAY
Xray/Radiopaque material/pills in gut/ABD
Associated Diseases & Rule outs
Associated Disease & Complications
Agranulocytosis
Alveoloproteinosis, pulmonary
Anemia, aplastic
Drug induced Hepatic toxicity
Drug induced Interstitial Lung disease.
Drug induced Lung disease.
Drug induced Pulmonary fibrosis.
Fetal anomaly
Gynecomastia
Interstitial lung involvement/manifestation
Pulmonary fibrosis
Retroperitoneal fibrosis
Toxic hepatitis
Veno-occlusive hepatic disease
Disease Mechanism & Classification
Drugs
DRUG/Alkylating agents (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Oral Anti-cancer drug (ex)
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Chronic intrinsic restrictive lung
Pathophysiology/Interstitial lung disorder (ex).
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 4 Bis(methanesulfonoxy)butane, 1,4 Bis(methanesulfonoxy)butane, 1,4 Bitanediol Dimethanesulfonate Esters, 1,4 Butanediol dimethanesulfonate, 1,4 Butanediol Dimethylsulfonate, 1,4 Di(methanesulfonyloxy)butane, 1,4 Di(methylsulfonyloxy)butane, admin, BSF, BU, BUS, Bussulfam, Busulfan, Busulfan (product), Busulfan (substance), BUSULFAN PREPARATION, Busulfanum, busulphan, Methanesulfonic Acid Tetramethylene Ester, Myeleukon, Sulfabutin, Tetramethylene Bis(methanesulfonate), Brand name/Myleran (Busulfan)
Treatment
Drug Dosage
DRUG/Oral medication (ex)
Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often

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External Links Related to Busulfan (Myleran) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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