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Disease Information for Busulfan (Myleran) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Breast Swelling Bilateral

Oral pigmentation lesions

Laboratory Tests

Abnormal Lab Findings - Decreased

Neutrophiles (Lab)

Diagnostic Test Results

Isotope Scan

Isotope/Gallium 67 lung scan abnormal

X-RAY

Xray/Radiopaque material/pills in gut/ABD

Associated Diseases & Rule outs

Associated Disease & Complications

Agranulocytosis

Alveoloproteinosis, pulmonary

Anemia, aplastic

Drug induced Hepatic toxicity

Drug induced Interstitial Lung disease.

Drug induced Lung disease.

Drug induced Pulmonary fibrosis.

Fetal anomaly

Gynecomastia

Interstitial lung involvement/manifestation

Pulmonary fibrosis

Retroperitoneal fibrosis

Toxic hepatitis

Veno-occlusive hepatic disease

Disease Mechanism & Classification

Drugs

DRUG/Alkylating agents (example)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Oral Anti-cancer drug (ex)

DRUG/Teratogenic potential/effect (D plus )

Pathophysiology

Pathophysiology/Chronic intrinsic restrictive lung

Pathophysiology/Interstitial lung disorder (ex).

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1 4 Bis(methanesulfonoxy)butane, 1,4 Bis(methanesulfonoxy)butane, 1,4 Bitanediol Dimethanesulfonate Esters, 1,4 Butanediol dimethanesulfonate, 1,4 Butanediol Dimethylsulfonate, 1,4 Di(methanesulfonyloxy)butane, 1,4 Di(methylsulfonyloxy)butane, admin, BSF, BU, BUS, Bussulfam, Busulfan, Busulfan (product), Busulfan (substance), BUSULFAN PREPARATION, Busulfanum, busulphan, Methanesulfonic Acid Tetramethylene Ester, Myeleukon, Sulfabutin, Tetramethylene Bis(methanesulfonate), Brand name/Myleran (Busulfan)

Treatment

Drug Dosage

DRUG/Oral medication (ex)

Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often

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External Links Related to Busulfan (Myleran) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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