Disease Information for Brown syndrome

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Clinical Manifestations
Signs & Symptoms
Difficulty Focusing Eyes
Diplopia Double vision
Eye pain on eye movement
Eye symptoms/signs
Inability to move eye upward
Associated Diseases & Rule outs
Associated Disease & Complications
Brown syndrome
Disease Mechanism & Classification
Class
CLASS/Muscle/tendon/extremities (category)
CLASS/Eye involvement/disorder (ex)
CLASS/Eyes/accessory (category)
Pathophysiology
Pathophysiology/Adhesions/bands/scars
Pathophysiology/Adhesions/superior oblique muscle
Pathophysiology/Eye movement problems
Process
PROCESS/Structural/anatomic/foreign body (category)
Synonyms
Synonym
Brown, Brown syndrome, Brown Tendon Sheath Syndrome, Brown's (tendon) sheath syndr, Brown's (tendon) sheath syndrome, Brown's sheath syndrome, Brown's syndrome, Brown's tendon sheath syndrome, Brown's tendon sheath syndrome (disorder), SOTSS Superior oblique tendon sheath syndrome, SOTSS Sup obl tend sheath synd, Sup oblique tendon sheath synd, Superior oblique tendon sheath syndrome, Syndrome Brown's Tendon Sheath, Tendon Sheath Syndrome of Brown, Synonym/Superior oblique tendon sheath syndrome
Definition

Brown Syndrome; Superior Oblique Tendon Sheath Syndrome;

Tendon Sheath Adherence, Superior Oblique; Acquired Brown Syndrome; Congenital Brown Syndrome; Primary Brown Syndrome; Secondary Brown Syndrome; Brown Syndrome is a rare eye disorder characterized by defects in eye movements; This disorder may be present at birth (congenital) or may occur as the result of another underlying disorder (acquired); Muscles control the movements of the eyes; Some of these muscles turn the eyeball up and down, move the eyeball from side to side, or enable the eyeball to rotate slightly in its socket; The superior oblique tendon sheath of the superior oblique muscle surrounds the eyeball; The symptoms of Brown Syndrome are caused by abnormalities of this tendon sheath including shortening, thickening, or inflammation; This results in the inability to move the affected eye upward----------[NORD 2005]-----------

Bilateral ptosis, congenital strabismus, musculus oblique superior syndrome, superior oblique tendon sheath syndrome, tendon sheath adherence syndrome, backward head tilt;

Fibrosis and shortening of the superior oblique tendon and attachment of the tendon sheath to the trochlea, resulting in restriction of eye movements; Palpebral fissure may widen when attempting upward gaze; Adduction and abduction restricted or abolished; Also associated with bilateral blepharoptosis, backward head tilt, and choroidal coloboma; Etiology unknown. Both sexes affected; present from birth-----------[whonamedit_com 2005]--------------

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External Links Related to Brown syndrome
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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