Disease Information for Bromocriptine (Parlodel) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Lactation suppression/nursing mother/complaint
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Baldness/Alopecia
Flushing
Hair loss
Non-scarring Alopecia/balding
Impotence, relative
Sexual dysfunction
Vomiting
Nightmares/excess dreaming (Paroniria)
Increased libido
Increased blinking frequency
Laboratory Tests
Abnormal Lab Findings - Decreased
Growth hormone/STH, plasma (Lab)
Prolactin (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Alopecia areata
Drug induced Baldness/Alopecia
Drug induced Dreaming/nightmares (Paroniria)
Drug induced Impotence.
Drug induced Pleural effusion
Impotence/Erectile dysfunction disorder
Pericardial effusion
Raynaud's syndrome
Retroperitoneal fibrosis
Disease Mechanism & Classification
Drugs
DRUG/Anti-parkinsons medication (examples)
DRUG/Dopamine agonist/CNS drug (example)
DRUG/Dopamine Receptor agonist/CNS
DRUG/Dopaminergic Anti-Parkinson's medication
DRUG/Serotonin reuptake inhibitor/CNS effect
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
2 Br alpha ergocryptine, 2 Bromo alpha ergocryptine, 2 Bromo alpha ergokryptine, 2 Bromoergocryptine, 2 Bromoergokryptine, admin, BRCR, Brom ergocryptine, Bromocriptin, Bromocriptine, Bromocriptine (endocrine use), Bromocriptine (endocrine use) (product), Bromocriptine (endocrine use) (substance), Bromocriptine (endocrine), Bromocriptine (endocrine) (product), Bromocriptine (endocrine) (substance), Bromocriptine (parkinsons), Bromocriptine (parkinsons) (product), Bromocriptine (parkinsons) (substance), Bromocriptine (product), Bromocriptine (substance), BROMOCRIPTINE PREPARATION, Bromocryptin, Bromocryptine, BROMOERGOCRYPTINE 02, Ergotaman 3',6',18 trione 2 bromo 12' hydroxy 2' (1 methylethyl) 5'alpha (2 methylpropyl), Brand name/Cycloset (Bromocriptine Myselate), Brand name/Parlodel (Bromocriptine)
Treatment
Drug Dosage
DRUG/.$$$$ Very Expensive
DRUG/Dose 2.5 mgm (Unit/Pill/Capsule size).
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Dose once daily (RX)
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Anti-parkinsonism drug; CNS Dopamine agonist drug ergot derivative; used in prolactinemia and acromegaly and as anti-parkinsonism drug; oral preparation---------------------------

Dopamine agonists

Dopamine agonists act directly on dopamine receptors, and their use in parkinsonism is associated with a lower incidence of the response fluctuations and dyskinesias that occur with long-term levodopa therapy. They were previously reserved for patients who had either become refractory to levodopa or developed the "on-off phenomenon." However, they are now best given either before the introduction of levodopa or with a low dose of Sinemet 25/100 (carbidopa 25 mg and levodopa 100 mg), one tablet three times daily when dopaminergic therapy is first introduced; the dose of Sinemet is kept constant, while the dose of the agonist is gradually increased. Two agonists, are bromocriptine and pergolide, are ergot derivatives. The initial dosage of bromocriptine is 1.25 mg twice daily; this is increased by 2.5 mg at 2-week intervals until benefit occurs or side effects limit further increments. The usual daily maintenance dose in patients with parkinsonism is between 10 and 30 mg. Pergolide is similarly started in a low dose (eg, 0.05 mg daily) and built up gradually depending on the response and tolerance.------------------------------------------------------

Side effects include anorexia, nausea, vomiting, constipation, postural hypotension, digital vasospasm, cardiac arrhythmias, various dyskinesias and mental disturbances, headache, nasal congestion, erythromelalgia, and pulmonary infiltrates. There are rare reports of pericardial, pleural, or pulmonary fibrosis; pergolide has also been associated with cardiac valvopathy. Bromocriptine and pergolide have largely been replaced with other agents because of these side effects.

[current dxrx 2005 accessmedicine.com]

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External Links Related to Bromocriptine (Parlodel) Administration/Toxicity
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PubMed (National Library of Medicine)
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Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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