Disease Information for Breast cystosarcoma phyllodes

Clinical Manifestations
Signs & Symptoms
Breast mass
Breast Pain
Breast pain/soreness/Mastalgia
Breast Swelling Unilateral
Clinical Presentation & Variations
Presentation/Breast Carcinoma Young Woman
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Sex & Age Groups
Population/Adult Aged Only
Diagnostic Test Results
BX/Breast biopsy/Abnormal
Xray/Mammogram abnormal
Associated Diseases & Rule outs
Rule Outs
Adenocarcinoma, breast/inflammatory
Breast abscess
Associated Disease & Complications
Breast cystosarcoma phyllodes
Metastatic lung disease
Disease Mechanism & Classification
CLASS/Breast (category)
Pathophysiology/Fast Growing tumor
PROCESS/Benign tumor (ex).
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Malignancy/cancer (ex)
PROCESS/Neoplastic (category)
Drug Therapy - Indication
Surgical Procedures or Treatments

Cystosarcoma phyllodes (CSP) is a rare, predominantly benign tumor that occurs almost exclusively in the female breast; Its name is derived from the Greek words sarcoma, meaning fleshy tumor, and phyllo, meaning leaf; Grossly, the tumor displays characteristics of a large malignant sarcoma, takes on a leaflike appearance when sectioned, and displays epithelial cystlike spaces when viewed histologically (hence the name); Because most tumors are benign, the name may be misleading; Thus, the favored terminology is now phyllodes tumor; Pathophysiology: Phyllodes tumor is the most commonly occurring nonepithelial neoplasm of the breast but represents only about 1% of tumors in the breast; It has a sharply demarcated smooth texture and is typically freely movable; It is a relatively large tumor, and the average size is 5 cm; However, lesions more than 30 cm in size have been reported; In the US: No difference in phyllodes tumor frequency appears to exist between patients from the United States and patients from other countries; Phyllodes tumors comprise less than 1% of all breast neoplasms;

Mortality/Morbidity: About 90% of phyllodes tumors are benign and about 10% are malignant; The benign tumors, although they will not metastasize, do have a tendency to grow aggressively and recur locally; The malignant tumors metastasize hematogenously similar to other sarcomas; Unfortunately, the pathologic appearance does not always predict the clinical behavior, so there is always some uncertainty about the classification of some cases; Recurrent malignant tumors seem to be more aggressive than the original tumor; The lungs are the most common metastatic site, followed by the skeleton, heart, and liver; Symptoms from metastatic involvement may arise from a few months to as late as 12 years after initial therapy; Most patients with metastases die within 3 years of initial treatment; No cures for systemic metastases exist; Roughly 30% of patients with malignant phyllodes tumors die from the disease; Race: A racial predilection does not appear to exist; Sex: Phyllodes tumors occur almost exclusively in females; Rare case reports have been described in males; Age: Phyllodes tumors can occur in people of any age; however, the median age is the fifth decade of life; Some juvenile fibroadenomas in teenagers can look histologically like phyllodes tumors, but they behave in a benign fashion similar to other fibroadenomas; --------------[EMedicine website 2007]-------------Median age 54 year old female


External Links Related to Breast cystosarcoma phyllodes
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)