Disease Information for Botulinum toxin/deliberate exposure

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Clinical Manifestations
Signs & Symptoms
Vertical Diplopia
Tachycardia/Fast heart rate
Constipation in Elderly
Drooling
Excess salivation/hypersalivation
Foaming/Frothing at the mouth
Sialorrhea/Ptyalism
Acute Motor Weakness
Flaccid jaw
Muscle tone/decreased
Muscle weakness
Cranial nerve abnormalities/involvement/signs
Dysarthria
Flaccid muscle paralysis
Level of alertness maintained
Nasal speech/regurgitation
Paralysis
Paralysis tongue/Aphasia/Aphonia
Retained eye tracking/infant bulbar signs
Slurred speech
Slurred Speech/Acute
Slurred speech/Chronic
Bradypnea Decreased respiratory rate
Dyspnea
Shallow breathing
Shortness of breath/SOB
Difficulty Talking
Nasal/Hyponasal sound to voice
Weakness
Blurred Cloudy Vision
Difficulty Focusing Eyes
Dimming vision/acute
Diplopia Double vision
Double Image Vision Confirmed
Mydriasis/wide pupils
Disease Progression
Course/Acute
Course/Acute only
Course/Catastrophic presentation/onset
Demographics & Risk Factors
Exposure Factors
Exposure/Massive sudden population illness/death agent
Exposure/Terrorist biologic weapon agents
Exposure/Terrorist/Chemical-biological weapon (CBW)
Event, Activity, Behavioral & Seasonal Factors
Event/Mass exposure/community illness/death
Laboratory Tests
Microbiology & Serology Findings
Food Specimen Botulinum toxin (Type A-E)
Microlab/Serum botulism toxin (type A-E)/present
Microlab/Stool botulinum toxin (Type A-E)
Abnormal Lab Findings (Non Measured)
Microlab/Vomitus botulinum toxin (Type A-E)
Toxin chromatography indentification/foods (Lab)
Diagnostic Test Results
Electrodiagnosis
EMG/Botulism pattern
EMG/NCS Axonal disease pattern
Associated Diseases & Rule outs
Associated Disease & Complications
Acidosis, respiratory
Acute respiratory failure/Respiratory arrest
Apnea
Botulinum toxin/deliberate exposure
Bulbar paralysis
Constipation
Hypoventilation, alveolar
Laryngeal edema
Motor neuropathy
Obstipation
Ophthalmoplegia
Paralytic Disorder
Respiratory muscle weakness
Tracheal edema
Vertical squint/strabismus
Disease Mechanism & Classification
Specific Agent
AGENT/Aerosolized bioterror weapon
Pathophysiology
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Poison/specific (category)
Toxin
TOXIN/Aerosolized Terror/Weapon chemical
TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
TOXIN/CBW Biologic poison/non-living (ex)
TOXIN/CDC Reportable/Public health issue
TOXIN/Decreases Respiratory Rate
TOXIN/Neurotoxin effect
TOXIN/NOT Diagnosed on USUALToxic screens
TOXIN/Poison/Botanical/alkaloids/plant toxins (category)
Definition

Botulism is also due to decreased release of acetylcholine from presynaptic terminals; Toxin produced by Clostridium botulinum spores irreversibly binds to the terminal cholinergic nerve twigs; The result is profound weakness, sometimes with respiratory compromise, shortly after eating contaminated food; A mild decremental response to repetitive nerve stimulation occurs, but a pronounced incremental response occurs after exercise or with rapid (20-Hz) repetitive nerve stimulation [Adapted Family Practice Notebook 2004]

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External Links Related to Botulinum toxin/deliberate exposure
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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