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- Disease Information
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Disease Information for Botulinum toxin/deliberate exposure
- Clinical Manifestations
- Signs & Symptoms
- Vertical Diplopia
- Tachycardia/Fast heart rate
- Constipation in Elderly
- Drooling
- Excess salivation/hypersalivation
- Foaming/Frothing at the mouth
- Sialorrhea/Ptyalism
- Acute Motor Weakness
- Flaccid jaw
- Muscle tone/decreased
- Muscle weakness
- Cranial nerve abnormalities/involvement/signs
- Dysarthria
- Flaccid muscle paralysis
- Level of alertness maintained
- Nasal speech/regurgitation
- Paralysis
- Paralysis tongue/Aphasia/Aphonia
- Retained eye tracking/infant bulbar signs
- Slurred speech
- Slurred Speech/Acute
- Slurred speech/Chronic
- Bradypnea Decreased respiratory rate
- Dyspnea
- Shallow breathing
- Shortness of breath/SOB
- Difficulty Talking
- Nasal/Hyponasal sound to voice
- Weakness
- Blurred Cloudy Vision
- Difficulty Focusing Eyes
- Dimming vision/acute
- Diplopia Double vision
- Double Image Vision Confirmed
- Mydriasis/wide pupils
- Disease Progression
- Course/Acute
- Course/Acute only
- Course/Catastrophic presentation/onset
- Demographics & Risk Factors
- Exposure Factors
- Exposure/Massive sudden population illness/death agent
- Exposure/Terrorist biologic weapon agents
- Exposure/Terrorist/Chemical-biological weapon (CBW)
- Event, Activity, Behavioral & Seasonal Factors
- Event/Mass exposure/community illness/death
- Laboratory Tests
- Microbiology & Serology Findings
- Food Specimen Botulinum toxin (Type A-E)
- Microlab/Serum botulism toxin (type A-E)/present
- Microlab/Stool botulinum toxin (Type A-E)
- Abnormal Lab Findings (Non Measured)
- Microlab/Vomitus botulinum toxin (Type A-E)
- Toxin chromatography indentification/foods (Lab)
- Diagnostic Test Results
- Electrodiagnosis
- EMG/Botulism pattern
- EMG/NCS Axonal disease pattern
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Acidosis, respiratory
- Acute respiratory failure/Respiratory arrest
- Apnea
- Botulinum toxin/deliberate exposure
- Bulbar paralysis
- Constipation
- Hypoventilation, alveolar
- Laryngeal edema
- Motor neuropathy
- Obstipation
- Ophthalmoplegia
- Paralytic Disorder
- Respiratory muscle weakness
- Tracheal edema
- Vertical squint/strabismus
- Disease Mechanism & Classification
- Specific Agent
- AGENT/Aerosolized bioterror weapon
- Pathophysiology
- Pathophysiology/Tissue hypoxia/potential
- Process
- PROCESS/Poison/specific (category)
- Toxin
- TOXIN/Aerosolized Terror/Weapon chemical
- TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
- TOXIN/CBW Biologic poison/non-living (ex)
- TOXIN/CDC Reportable/Public health issue
- TOXIN/Decreases Respiratory Rate
- TOXIN/Neurotoxin effect
- TOXIN/NOT Diagnosed on USUALToxic screens
- TOXIN/Poison/Botanical/alkaloids/plant toxins (category)
- Definition
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Botulism is also due to decreased release of acetylcholine from presynaptic terminals; Toxin produced by Clostridium botulinum spores irreversibly binds to the terminal cholinergic nerve twigs; The result is profound weakness, sometimes with respiratory compromise, shortly after eating contaminated food; A mild decremental response to repetitive nerve stimulation occurs, but a pronounced incremental response occurs after exercise or with rapid (20-Hz) repetitive nerve stimulation [Adapted Family Practice Notebook 2004]
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- External Links Related to Botulinum toxin/deliberate exposure
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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