Disease Information for Bone necrosis/infarct/osteonecrosis

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Clinical Manifestations
Signs & Symptoms
Medial Knee Pain/Tenderness
Skeletal problems/symptoms/signs
Disease Progression
Course/Chronic disorder
Demographics & Risk Factors
Established Disease Population
Patient/Alcoholism/chronic alcoholic
Patient/Corticosteroid treatment
Patient/Gauchers disease
Patient/Hyperlipidemia
Patient/Obese
Patient/Oral contraceptive/treatment
Patient/Sickle cell/anemia
Patient/Pregnant
Patient/Diabetes mellitus
Patient/Renal transplant
Occupational Factors
Occupation/Caisson worker
Occupation/Diver
Sex & Age Groups
Population/Male
Diagnostic Test Results
CT Scan
CT/Bone Mineral Density/Increased
MRI/Bones/Skeletal abnormality
X-RAY
Xray/Bone infarct
Xray/Increased bone density
Xray/Split or double cortex of bone
Xray/Subchondral bone absorption/crescent sign
Associated Diseases & Rule outs
Rule Outs
Osteomyelitis
Associated Disease & Complications
Bone necrosis/infarct/osteonecrosis
Disease Mechanism & Classification
Class
CLASS/Bone disorder (ex)
CLASS/Femur involvement/disorder (ex)
CLASS/Long bone involvement/disorder (ex)
CLASS/Skeletal (category)
Process
PROCESS/Arteriosclerosis/vascular/venous (category)
PROCESS/Ischemic process (ex)
PROCESS/Necrosis (ex)
PROCESS/Use/Age/atrophic disorder (category)
Definition

Osteonecrosis; Aseptic Necrosis; Avascular Necrosis of Bone

Ischemic Necrosis of Bone; Osteonecrosis is the destruction (necrosis) of bone tissue, often due to an interference with the supply of blood to the bone; It most commonly affects the joints and bones of the hips, knees and/or shoulders; It may occur as a result of bone injuries (trauma-related osteonecrosis) or in conjunction with other diseases or risk factors (nontraumatic osteonecrosis); Risk factors include excessive alcohol intake, some blood coagulation disorders, inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus, and reactions to some medications such as steroids ; [NORD 2005]------------------------------Aseptic necrosis (also referred to as avascular necrosis or osteonecrosis) is a condition that results from poor blood supply to an area of bone causing bone death; This is a serious condition because the dead areas of bone do not function normally, are weakened, and can collapse; causes aseptic necrosis?

Aseptic necrosis can be caused by trauma and damage to the blood vessels that supply bone its oxygen; Other causes of poor blood circulation to the bone include an embolism of air or fat that blocks the blood flow through the blood vessels, abnormally thick blood (hypercoaguable state), and inflammation of the blood vessel walls (vasculitis);

What conditions are associated with aseptic necrosis?

Conditions that are associated with aseptic necrosis include alcoholism, steroid usage, Cushing"s syndrome, radiation exposure, sickle cell disease, pancreatitis, Gaucher"s disease, and systemic lupus erythematosus.

The diagnosis of aseptic necrosis can be made with x-rays, but this is a later stage finding; Earlier signs of avascular necrosis can be detected with MRI scanning or suggested by nuclear bone scanning;

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External Links Related to Bone necrosis/infarct/osteonecrosis
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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