Disease Information for Blepharospasm/Meige Syndrome

Clinical Manifestations
Signs & Symptoms
Facial grimacing
Segmental dystonia
Acute Vision Loss
Eye symptoms/signs
Eyelid Pain
Eyelid Retraction
Associated Diseases & Rule outs
Rule Outs
Associated Disease & Complications
Oromandibular facial dystonia syndrome
Disease Mechanism & Classification
CLASS/Eyelid manifestations/involvement
CLASS/Eyes/accessory (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Benign essential blepharospasm, blepharospasm, Blepharospasm (disorder), BLEPHAROSPASM BENIGN ESSENTIAL, Blepharospasm syndrome, Blepharospasms, Essential blepharospasm, Eyelid twitching, SPASM EYELID, Spasm of eyelids, Twitch(ing) eyelid, twitching eyelid, Synonym/Blepharospasm-Oromandibular Dystonia, Synonym/Brueghel Syndrome, Synonym/Meige's blepharospasm syndrome, Synonym/Meiges Syndrome, Synonym/Segmental Cranial Dystonia, Synonym/Segmental Dystonia Syndrome
Drug Therapy - Indication

Excessive winking; tonic or clonic spasm of the orbicularis oculi muscle;---------------------------------------Meige Syndrome; ;Brueghel Syndrome ;Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome ;Segmental Cranial Dystonia; Meige Syndrome is a rare neurological movement disorder (dyskinesia) characterized by spasms of the muscles of the eyelids and associated loss of tone in these eyelid muscles; Symptoms may include excessive blinking (blepharospasm) or involuntary eyelid closure; On occasion, the muscles of the face may also be involved; The exact cause of Meige Syndrome is not known; This disorder generally affects people during late middle age; [NORD]----------------------------

Segmental Dystonia

As many as 30 percent of patients with a primary focal dystonia experience dystonic spasms in areas next to the primary site. When dystonia affects two areas of the body that are next to each other, this is termed segmental dystonia. Dystonic spasms affect at least 2 adjacent areas of the body, such as facial and neck muscles ; muscle groups of the neck and upper arm; or trunk and leg muscles.

One common segmental dystonia involves muscles of the eyelids, jaw, mouth, and lower face. Known as Meige syndrome, the condition is characterized by periodic or sustained closure of the eyelids (blepharospasm). Eyelid closure is accompanied by forceful spasms of jaw opening or closure, clenching or grinding of the teeth, sideways displacement of the jaw, lip tightening and pursing, and tongue protrusion . In addition, this form of segmental dystonia may spread to neck muscles or other muscle groups. Meige syndrome more frequently affects women than men and typically becomes apparent during the sixth decade of life.

Multifocal Dystonia

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External Links Related to Blepharospasm/Meige Syndrome
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)