Disease Information for Binswanger's dementia

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Clinical Manifestations
Signs & Symptoms
Failure to Thrive
Apathy/Indifference
Aphasia
Cognitive defect
Difficulty concentrating/Distraction/Forgetful
Dysarthria
Executive function loss/apathy/inertia
Gait disturbance/abnormality
Hemianopsia/homonymous/sign
Irritability/short tempered
Memory Loss in Elderly
Motor slowing
Perseveration
Personality change
Poor coordination legs/feet
Progressive neurological disorder/signs
Seizures
Short term memory loss
Slow speech
Stroke syndrome/signs
Emotional/affective lability
Mood swings/changes
Psychomotor retardation
Difficulty Talking
Incontinent/noncognizant type
Urinary incontinence in Children
Urine Incontinence
Falling
Falling/in the elderly/complaint
Listlessness/lassitude
Walking difficulties
Clinical Presentation & Variations
Presentation/Dementia Ataxia Urine incontinent
Presentation/Progressive Dementia
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Progressive
Onset/insidious
Demographics & Risk Factors
Population Group
Aged Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Elderly Aged
Population/Seventies Adult
Population/Sixties-adult
Diagnostic Test Results
Pathology
PATH/Brain abnormal
PATH/Brain white matter multifocal lesions
PATH/Brain/White matter/deficient myelin
PATH/Subcortical CNS process/lesion
CT Scan
CT Scan/Head Enlarged brain ventricles
MRI/Head Deep white matter/multiple lesions
MRI/Head Dilated ventricles
MRI/Head Scan Abnormal
MRI/Head scan pontine lesion
MRI/Head Ventricular enlargement
MRI/Head White matter lesions
Associated Diseases & Rule outs
Rule Outs
Alcohol dementia
Alzheimers disease
Dementia, multiple-infarct type
General paresis/CNS syphilis
Heavy metals poisoning
Mercury poisoning/toxicity
Multiple sclerosis
Normal pressure hydrocephalus
Progressive leukoencephalopathy/multifocal
Associated Disease & Complications
Amnesia
Binswanger's dementia
CNS disease/involvement
Convulsions (grand mal)
Dementia
Depression, reactive
Hemiparesis
Leukoencephalopathy process
Neurodevelopmental disorders
Parkinsonism, secondary
Parkinsonism-dementia complex
Pseudobulbar palsy syndrome
Syncope/Fainting
Disease Synergy - Causes
Synergy/Hypertension
Disease Mechanism & Classification
Class
CLASS/Primary organ/system disorder (ex)
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/CNS degeneration
Process
PROCESS/Arteriosclerosis/vascular/venous (category)
PROCESS/Degenerative/necrosis disorder (category)
PROCESS/Idiopathic/unclassified/unknown (category)
PROCESS/Use/Age/atrophic disorder (category)
PROCESS/CNS/White matter disorder (ex)
Synonyms
Synonym
ARTERIOSCLEROTIC ENCEPH SUBCORTICAL, Arteriosclerotic Encephalopathies Subcortical, Arteriosclerotic Encephalopathy Subcortical, Binswanger, BINSWANGER DIS, Binswanger Disease, BINSWANGER ENCEPH, Binswanger Encephalopathy, Binswanger's dementia, Binswanger's disease, Binswanger's Encephalopathy, Chr progres subcort encephalop, CHRONIC PROGRESSIVE SUBCORTICAL ENCEPH, Chronic progressive subcortical encephalopathy, DEMENTIA BINSWANGER, DEMENTIA SUBCORTICAL ARTERIOSCLEROTIC, Disease Binswanger, ENCEPH BINSWANGER, ENCEPH BINSWANGERS, ENCEPH CHRONIC PROGRESSIVE SUBCORTICAL, ENCEPH SUBCORTICAL ARTERIOSCLEROTIC, ENCEPH SUBCORTICAL CHRONIC PROGRESSIVE, Encephalitis subcorticalis chronica, Encephalopathies Subcortical Arteriosclerotic, Encephalopathy Binswanger, Encephalopathy Binswangers, Encephalopathy Binswanger's, Encephalopathy Chronic Progressive Subcortical, Encephalopathy Subcortical Arteriosclerotic, Encephalopathy Subcortical Chronic Progressive, LEUKOENCEPH SUBCORTICAL, Leukoencephalopathies Subcortical, Leukoencephalopathy Subcortical, Subcort arterioscl encephalop, Subcort atheroscltic dementia, SUBCORTICAL ARTERIOSCLEROTIC ENCEPH, Subcortical Arteriosclerotic Encephalopathies, Subcortical arteriosclerotic encephalopathy, Subcortical atherosclerotic dementia, SUBCORTICAL ENCEPH CHRONIC PROGRESSIVE, Subcortical Encephalopathy Chronic Progressive, Subcortical leucoencephalopathy, SUBCORTICAL LEUKOENCEPH, Subcortical Leukoencephalopathies, Subcortical Leukoencephalopathy, Subcortical leukoencephalopathy (disorder), Synonym/Binswanger's Encephalitis/subcortical, Synonym/Binswanger's encephalopathy, Synonym/Chronic subcortical encephalitis, Synonym/Multi-infarct dementia Binswanger's type, Synonym/SAE, Synonym/Subcortical arteriosclerotic encephalopathy, Synonym/Vascular dementia Binswanger's type
Treatment
Drug Therapy - Indication
RX/Donepezil (Aricept)
RX/Memantine (Namenda)
RX/Risperidone (Risperdal)
RX/SSRI Indication
Other Treatments
TX/Supportive/Symptomatic treatment
Definition

NINDS Binswanger"s Disease;Subcortical Arteriosclerotic Encephalopathy, Dementia - Subcortical;Binswanger"s disease, sometimes referred to as subcortical dementia, is a rare form of dementia characterized by cerebrovascular lesions in the deep white-matter of the brain, loss of memory and cognition, and mood changes; Patients usually show signs of abnormal blood pressure, stroke, blood abnormalities, disease of the large blood vessels in the neck, and disease of the heart valves; Other prominent features of the disease include urinary incontinence, difficulty walking, clumsiness, slowness of conduct, lack of facial expression, and speech difficulty; These symptoms, which tend to begin after the age of 60, are not always present in all patients and may sometimes appear only as a passing phase; There is no specific course of treatment for Binswanger"s disease; Treatment is symptomatic, often involving the use of medications to control high blood pressure, depression, heart arrhythmias and low blood pressure; Binswanger"s disease is a slowly progressive condition for which there is no cure; The disorder is often marked by strokes and partial recovery.

[NINDS/NIH 2005]------------------------------------Binswanger"s Disease; Binswanger"s Encephalopathy

Multi-infarct Dementia, Binswanger"s Type; SAE; Subcortical Dementia ; Subcortical Ischemic Vascular Disease;

Vascular Dementia, Binswanger"s Type

Binswanger"s disease is a rare, progressive neurological disorder characterized by injuries (lesions) to the blood vessels supplying the deep white-matter of the brain; Affected individuals usually experience a gradual loss of memory, cognitive, and behavioral abilities, usually over a ten-year period; In some cases, symptoms and physical findings associated with Binswanger"s disease may stabilize or improve for a brief time; however, in most cases, progression of the disorder usually returns; Affected individuals experience progressive memory loss and deterioration of intellectual abilities (dementia), strokes, paralysis of one or the other side of the body (hemiparesis), electrical disturbance in the brain (seizures), and/or an abnormally slow, unsteady walk (abnormal gait)---------------- [NORD 2005]---------------

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External Links Related to Binswanger's dementia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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