Disease Information for Arsenical vesicants/CBW Weapon

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Clinical Manifestations
Signs & Symptoms
Red/erythema skin discoloration
Burning blebs/sudden appearance/skin
Burning/stinging skin sensations/diffuse
Cold clammy skin
Erythroderma
Sweat smells of garlic/Body odor
Yellow skin discoloration
Choking
Gagging
Nausea
Vomiting
Drooling
Foaming/Frothing at the mouth
Palate edema/Soft palate
Palate Erythema/Soft Palate
Bronchorrhea/excess watery sputum
Bronchospasm signs
Cough
Dyspnea
Hemoptysis
Shortness of breath/SOB
Wheezing
Burning/Raw throat feeling
Coryza
Pharyngeal edema/throat swelling
Runny nose/rhinorrhea
Sneezing
Sneezing/paroxysms
Dark urine
Cold clammy pale status
Collapse/Prostration
Bloodshot eyes/Conjunctival injection
Eye Pains, Bilateral
Red Eyes Bilateral
Scleral Injection
Temporary blindness
Clinical Presentation & Variations
Presentation/Vesicant Eye Skin Nose Lungs Immediate
Disease Progression
Course/Acute
Course/Acute only
Demographics & Risk Factors
Exposure Factors
Exposure/Terrorist Chemical weapon agent
Exposure/Terrorist/Chemical-biological weapon (CBW)
Occupational Factors
Occupation/Soldier/officer military
Event, Activity, Behavioral & Seasonal Factors
Event/Mass exposure/community illness/death
Associated Diseases & Rule outs
Associated Disease & Complications
Acute respiratory failure/Respiratory arrest
Agranulocytosis
Anemia
Anemia, hemolytic, toxic
Asphyxia/suffocation
Asthma
Blepharospasm
Bone marrow failure/exhaustion
Chemical burn/dermatitis
Chemical pneumonitis
Chemical Tracheobronchitis
Chemical/caustic oral burn
Conjunctivitis, chemical
Dermatitis/Chronic rash
Epistaxis/nosebleed
Hemolysis anemia/acute/active
Keratitis
Laryngeal edema
Myelosuppression
Pneumonia, aspiration
Respiratory distress (adult) syndrome
Sclerocornea/Corneal scar
Toxic hepatitis
Tracheal edema
Tracheal necrosis/pseudomembrane/asphyxia
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Hemolytic process/effect
Pathophysiology/Bronchospasm
Pathophysiology/Tissue hypoxia/potential
Process
PROCESS/Poison/specific (category)
Toxin
TOXIN/Absorbed/skin/eyes/mucous membranes contact
TOXIN/Aerosolized Terror/Weapon chemical
TOXIN/Caustic mouth/lip/oropharyngeal burning pathology
TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
TOXIN/CBW irritants/Military use non-lethal
TOXIN/CBW Military chemical Incapacitant/non-lethal
TOXIN/Chemical Weapon/Terrorist/Military
TOXIN/Fulminant course/death in hours
TOXIN/Gas smells like Geraniums
TOXIN/Gas smells like rotting fruit
TOXIN/Highly soluble irritant gas (eyes>lungs)
TOXIN/Immediate death/minutes
TOXIN/Immediate effect/Severe
TOXIN/Lethal possible
TOXIN/Local irritant/Contact/Caustic/Blister
TOXIN/Penetrates rubber/clothing
TOXIN/Vesicant CBW agent
TOXIN/Weapon/anti-personnel agent/poison (ex)
TOXIN/Skin reaction/chemical irritant
TOXIN/Dry land drowning/Asphyxia/vapor-gas
Synonyms
Synonym
272 VESICANTS, Arsenic and its compounds, Arsenic causing toxic effect, Arsenic or arsenic compound causing toxic effect, ARSENIC POIS, ARSENIC POIS NERVOUS SYSTEM, Arsenic Poisoning, Arsenic Poisoning Nervous System, Arsenic poisoning syndrome, Arsenic Poisonings, Arsenical Neurotoxicity Syndrome, Arsenical Neurotoxicity Syndromes, Arsenical toxicity, As or As comp caus toxic effct, CBW Weapon, NERVOUS SYSTEM POIS ARSENIC, Nervous System Poisoning Arsenic, NEUROTOX SYNDROME ARSENICAL, Neurotoxicity Syndrome Arsenical, Neurotoxicity Syndromes Arsenical, POIS ARSENIC NERVOUS SYSTEM, Poisoning Arsenic, Poisoning Arsenic Nervous System, Poisoning by arsenic or its compounds of undetermined intent, Poisoning by arsenic or its compounds of undetermined intent (disorder), Poisonings Arsenic, Syndrome Arsenical Neurotoxicity, Syndromes Arsenical Neurotoxicity, Toxic effect of arsenic and its compounds, Toxic effect of arsenic AND OR its compounds, Toxic effect of arsenic AND OR its compounds (disorder), Vesicant, Vesicant (substance), VESICANTS, Synonym/ Arsenical organic vesicant CBW (L/ED/PD/MD), Synonym/Adamsite (Diphenylaminearsine) CBW, Synonym/DA (Diphenylchlorarsine) CBW, Synonym/DM (Diphenylaminarsine) CBW, Synonym/Lewisite gas/arsine
Treatment
Other Treatments
TX/Endotracheal airway.
Definition

Weapons vesicant organic arsenicals known as L,MD,PD,ED;

are CBRNE agents; This is a Vesicant with IMMEDIATE effect with blinding blepharospasm, edema lids, corneal burn; rhinorrhea, bronchorrhea, epistaxis and a bloody mucous cough productive in high dose trachea burn, sloughing pseudomembrane and "dry-land drowning" asphyxia; always with erythema, burning, itching, exposed skin promply forming vesical, blisters, and bulla; hypovolemia and shock from fluid shift; this is a cheap easy to make CBW but hard to handle as extremely volatile ; used by Italy and Japan in the 1930"s; Lewsite is L and smells like geraniums, the others smell like rotting fruit and are MD (Methyldichloroarsine), ED (Ethyldichloroarsine), and PD (Phenyldichloroarsine); Phosgene oxime is a weaker vesicant; mustard gas is a slower acting vesicant; heavy skin dose can cause hemolytic anemia like arsine

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PubMed (National Library of Medicine)
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Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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