Disease Information for Aristolochic acid herbal/toxicity

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Clinical Manifestations
Signs & Symptoms
Bilateral ankle swelling
Bilateral leg edema/swelling
Edema of Lower Extremities
Anuria
Bilateral CVA/kidney tenderness
Oliguria/sudden
Acutely ill patient/signs
Typical Clinical Presentation
Presentation/Renal Failure Worse Chronic Uremic patient
Disease Progression
Course/Acute
Demographics & Risk Factors
Established Disease Population
Patient/On Medications long term/ usually
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Renal function abnormalities (Lab)
URINE Dipstick /Blood abnormal
URINE Dipstick/Leukocytes Positive
URINE Pyuria
URINE Pyuria with negative cultures
URINE Sediment/Urinalysis abnormal
Abnormal Lab Findings - Decreased
BUN/Creatinine ratio (Lab)
Creatine clearance (Lab)
Abnormal Lab Findings - Increased
BUN/Blood urea nitrogen (Lab)
URINE Leukocytes
URINE Red blood cells
Diagnostic Test Results
Pathology
BX/Renal Abnormal
BX/Renal Atrophic renal tubules
BX/Renal Chinese herb nephropathy
BX/Renal Cortical tubule loss/interstitial fibrosis
X-RAY
Xray/Bilateral large kidneys/KUB
X-RAY With contrast
IVP/Bilateral large kidneys
Ultrasound
Ultrasound/Renal/Kidneys echogenic cortex bilateral
Associated Diseases & Rule outs
Associated Disease & Complications
Acute anuria/renal failure
Acute Renal Failure
Acute Tubulointerstitial Nephropathy
Aristolochic acid toxicity
Azotemia/Acute
Drug induced Nephritis/Nephropathy
Drug induced Renal failure,
Edema
Nephritis tubulointerstitial
Renal Failure Chronic
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Pyuria
Disease Synergy - Causes
Synergy/Age
Synergy/Uremia
Disease Mechanism & Classification
Class
CLASS/Renal/kidney involvement/disorder (ex)
CLASS/Urologic (category)
Drugs
DRUG/Carcinogenic potential
DRUG/Reaction to medication/drug induced (ex)
Process
PROCESS/Complicating disorder (ex)
PROCESS/Drug induced disorder (ex)
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
PROCESS/Poison/specific (category)
PROCESS/Poisoned organ/system (category)
PROCESS/Reference organ/system (category)
Toxin
TOXIN/Plant kidney toxin
TOXIN/Poison/Botanical/alkaloids/plant toxins (category)
TOXIN/Poisonous Plant (ex)
TOXIN/Potential carcinogen
Synonyms
Synonym
Aristolochic Acids, herbal toxicity, Herbal name Aristolochia clematetis, Herbal name Aristolochia debilis, Herbal name Aristolochia fangi, Herbal name Aristolochia serpentaria, Herbal name Asarum canadense, Herbal name Mu tong, Herbal name Qing mu xiang, Herbal synonym Sangree root, Herbal synonym Sangrel, Herbal synonym Serpentary/Serpentaria, Herbal synonym Wild ginger
Treatment
Drug Dosage
DRUG-Herbal HAZARDOUS (consumer reports 2004)
DRUG-Herbal Source China/Asia
DRUG-Herbal TOXIC in high dose:
DRUG-Herbal Traditional Chinese medicine
Definition

Aristolochic acid is toxic to kidneys; from botanical herbals Aristolochia, Bragantia, Asarum, Stephania, Clematis, Akebia, Cocculus, and Diploclisia; added to traditional medicine supplements especially Chinese and Ayurvedic medicines; also "joint ease", and "joint discomfort" and "quell fire" , and eczema tablets; pathology shows "chinese herbs nephropathy" pattern

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External Links Related to Aristolochic acid herbal/toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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