Disease Information for Anetoderma, perifollicular

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Clinical Manifestations
Disease Progression
Course/Chronic disorder
Course/Chronic only
Associated Diseases & Rule outs
Associated Disease & Complications
Anetoderma, perifollicular
Disease Mechanism & Classification
Class
CLASS/Dermatologic/Subcutaneous (category)
Process
PROCESS/Use/Age/atrophic disorder (category)
Synonyms
Synonym
Anetoderma perifollicular, Synonym/Blegvad-Haxthausen (Anetoderma/osteogenesis imp)
Definition

Anetoderma (anetos, Greek for slack) is a benign condition with focal loss of dermal elastic tissue, resulting in localized areas of flaccid or herniated saclike skin; The condition has been reported under various names, including macular atrophy and dermatitis atrophicans maculosa;

Historically, idiopathic lesions were classified based on a clinically inflammatory (Jadassohn-Pellizzari) or non-inflammatory (Schweninger-Buzzi) onset; However, both types of lesions may be found in the same patient, and they are histologically similar; Currently, anetoderma is classified as either primary anetoderma, which is idiopathic, or secondary anetoderma, which is associated with a variety of skin conditions, penicillamine use, or neonatal prematurity; The exact cause of anetoderma is unknown; Possible explanations for elastolysis include defective elastin synthesis, uncontrolled release of elastase by inflammatory cells, elastophagocytosis, or an immune mechanism-------[EMedicine-com 2005]-----------

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External Links Related to Anetoderma, perifollicular
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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