Disease Information for Amiodarone (Cordarone) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Blue/Blue-gray nose
Breast Swelling Bilateral
Blue skin discoloration/Skin color
Photosensitivity/Sunsensitive skin
Rash
Slate gray pigmentations
Goiter/thyroid enlargement/mass
Thyroid Mass
Paresthesias
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Transaminase elevation (Lab)
Abnormal Lab Findings - Decreased
FTI/Free Thyroxin Index (Lab)
Prealbumin levels (labs)
TSH/Thyroid stimulating hormone (Lab)
Abnormal Lab Findings - Increased
Aspartamine aminotransferase (SGOT, AST) (Lab)
AST (SGOT) (aspartamine transferase) (Lab)
Digoxin serum level (Lab)
Free T4 (Lab)
FTI/Free Thyroxin Index (Lab)
TSH/Thyroid stimulating hormone (Lab)
Diagnostic Test Results
Pathology
BX/Liver biopsy/Fatty change in liver tissue
Isotope Scan
Isotope/Gallium 67 lung scan abnormal
EKG (ECG)
EKG/Prominent U Waves (ECG)
EKG/Sinus bradycardia (ECG)
CT Scan
CT/Liver High Density/ABD
Associated Diseases & Rule outs
Rule Outs
Reye's syndrome
Associated Disease & Complications
Alveolar hemorrhage syndrome
Cardiac arrhythmias
Digoxin (Lanoxin) effect/toxicity
Drug induced Arrhythmias
Drug induced Goiter/Thyromegaly
Drug induced Interstitial Lung disease.
Drug induced Lung disease.
Drug induced Neutropenia.
Drug induced Peripheral neuropathy.
Drug induced Photosensitivity rash
Drug induced Pleural effusion
Drug induced Pulmonary fibrosis.
Drug rash/Drug induced rash
Fatty liver
Granulocytopenia/Neutropenia
Gynecomastia
Hyperpigmentation
Hyperthyroid status
Hypothyroidism (myxedema)
Hypothyroidism, iodide
Interstitial lung involvement/manifestation
Iodism/Iodide toxicity
Jod-Basedow's hyperthyroidism
Pericardial effusion
Peripheral neuropathy
Photosensitivity dermatitis
Phototoxicity
Polyneuritis
Pulmonary fibrosis
Respiratory distress (adult) syndrome
Sinus bradycardia
Steatohepatitis
Steatosis/Non-alcoholic steatosis hepatitis/NASH
Thyroiditis
Torsades de pointes/ventricular tachycardia
Toxic peripheral/polyneuropathy
Ventricular fibrillation
Ventricular tachycardia/arrest
Polyneuropathy
Disease Mechanism & Classification
Drugs
DRUG/Antiarrhythmic drug Class III/Beta blocker also
DRUG/Anti-arrhythmic medication (example)
DRUG/Cardiology usage
DRUG/Cardiovascular meds (examples)
DRUG/Class III antiarrhythmic agent (example)
DRUG/Decrease peripheral T4 to T3 conversion
DRUG/Important Acute care drugs (example)
DRUG/metabolized by CYP 3A pathway
DRUG/Narrow range of safety (effect/toxic)
DRUG/Potassium channel block myocardium
DRUG/Proarrhythmic drug effect (example)
DRUG/Specialized usage (example)
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Defective thyroid hormone biosynthesis
Pathophysiology/Inhib organification/iodine/thyroxin prod
Pathophysiology/Interstitial lung disorder (ex).
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Amiodarone, Amiodarone (product), Amiodarone (substance), AMIODARONE PREPARATION, Methanone (2 butyl 3 benzofuranyl)(4 (2 (diethylamino)ethoxy) 3,5 diiodophenyl), Brand name/Cordarone (Amiodorone), Brand name/Pacerone (Amiodarone)
Treatment
Drug Therapy - Contraindication
RX/Digoxin (Lanoxin)
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/.$$$$$ Most Expensive
DRUG/Dose 200 mgms (Unit/Pill/Capsule size)
DRUG/Dose Infusion mix 450 mgm/250 ml (CONFIRM this)
DRUG/Dose once daily (RX)
DRUG/Dose Unit dose Vial preparation
DRUG/Generic available
DRUG/Infusion option medication
DRUG/Injectable medication (parenteral)
DRUG/Intravenous administraton RX
DRUG/IV requires lesser dose/Caution
DRUG/Loading dose used medication (ex)
DRUG/Oral medication (ex)
Definition

Anti-arrhythmic medication; Von Williams class III with

much beta-blocker effect; Difficult to treat with this

drug as there are many side effects and complications; high iodide content

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External Links Related to Amiodarone (Cordarone) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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