Disease Information for Ambenonium (Mytelase) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Slow pulse/Bradycardia
Diaphoresis profuse/active sweating/acute
Hyperhidrosis/Chronic sweating excess
Sweating Excess Perspiration
Active Bowel Sounds
Borborygmi/Bowel sound increased
Cholinergic symptoms/signs
Lacrimation/excess tearing
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Laboratory Tests
Abnormal Lab Findings - Increased
Acetyl choline level (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Bradyarrhythmias
Cardiac conduction defects
Cholinergic crisis/toxidrome
Heart block, complete
Disease Mechanism & Classification
Drugs
DRUG/Acetylcholinesterase inhibitor
DRUG/Anti-Myasthenia Gravis medication (ex)
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Enteric/gut motor stimulation
DRUG/Important Acute care drugs (example)
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Specialized usage (example)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Acetyl choline accumulation
Pathophysiology/Peristalsis increased
Pathophysiology/Neuromuscular irritability
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Synonyms
Synonym
Ambenonium Chloride, Ambenonium chloride (substance), AMBENONIUM CHLORIDE PREPARATION, Ambestigmine chloride, Ammonium,(Oxalylbis(iminoethylene))bis((o chlorobenzyl)diethyl Dichloride, Benzenemethanaminium N,N' ((1,2 Dioxo 1,2 ethanediyl)bis(imino 2,1 ethanediyl))bis(2 chloro N,N diethyl Dichloride, Benzenemethanaminium N,N' ((1,2 dioxo 1,2 ethanediyl)bis(imino 2,1 ethanediyl))bis(2 chloro N,N diethyl) dichloride, Chloride Ambenonium, Misuran, Oxazyl, Win 8077, Brand name/Mytelase (Ambenonium)
Definition

Antimyasthenics are given by mouth or by injection to treat myasthenia gravis; cholinergic agonist; oral preparation

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External Links Related to Ambenonium (Mytelase) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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