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Disease Information for Ambenonium (Mytelase) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Slow pulse/Bradycardia

Diaphoresis profuse/active sweating/acute

Hyperhidrosis/Chronic sweating excess

Sweating Excess Perspiration

Active Bowel Sounds

Borborygmi/Bowel sound increased

Cholinergic symptoms/signs

Lacrimation/excess tearing

Tearing

Typical Clinical Presentation

Coma with cholinergic ( SLUD) signs

Laboratory Tests

Abnormal Lab Findings - Increased

Acetyl choline level (Lab)

Diagnostic Test Results

EKG (ECG)

EKG/Widened QRS pattern (ECG)

EKG/AV Nodal Block/Complete

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Associated Disease & Complications

Bradyarrhythmias

Cardiac conduction defects

Cholinergic crisis/toxidrome

Heart block, complete

Disease Mechanism & Classification

Drugs

DRUG/Acetylcholinesterase inhibitor

DRUG/Anti-Myasthenia Gravis medication (ex)

DRUG/Cholinergic agonist drug/effect (example)

DRUG/Enteric/gut motor stimulation

DRUG/Important Acute care drugs (example)

DRUG/Parasympatheticomemitic effect (ex)

DRUG/Specialized usage (example)

DRUG/Lowers seizure threshold

Pathophysiology

Pathophysiology/Acetyl choline accumulation

Pathophysiology/Peristalsis increased

Pathophysiology/Neuromuscular irritability

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Toxin

TOXIN/Decreases Heart Rate

TOXIN/SLUD response(sial/lacr/urine/dia)

Synonyms

Synonym

Ambenonium Chloride, Ambenonium chloride (substance), AMBENONIUM CHLORIDE PREPARATION, Ambestigmine chloride, Ammonium,(Oxalylbis(iminoethylene))bis((o chlorobenzyl)diethyl Dichloride, Benzenemethanaminium N,N' ((1,2 Dioxo 1,2 ethanediyl)bis(imino 2,1 ethanediyl))bis(2 chloro N,N diethyl Dichloride, Benzenemethanaminium N,N' ((1,2 dioxo 1,2 ethanediyl)bis(imino 2,1 ethanediyl))bis(2 chloro N,N diethyl) dichloride, Chloride Ambenonium, Misuran, Oxazyl, Win 8077, Brand name/Mytelase (Ambenonium)

Definition

Antimyasthenics are given by mouth or by injection to treat myasthenia gravis; cholinergic agonist; oral preparation

(Edit)

External Links Related to Ambenonium (Mytelase) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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