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Disease Information for Altretamine (HMM/Hexalen) Administration/Toxicity

Associated Diseases & Rule outs

Associated Disease & Complications

Fetal anomaly

Peripheral neuropathy

Polyneuritis

Polyneuropathy

Disease Mechanism & Classification

Drugs

DRUG/Alkylating agents (example)

DRUG/Anti-neoplastic medications (examples)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Cytotoxic/chemotherapy medication (example)

DRUG/H-CAP protocol (four drugs) (comb)

DRUG/Neurotoxicities/drug effect

DRUG/Teratogenic potential/effect (D plus )

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1,3,5 Triazine 2,4,6 triamine N,N,N',N',N'',N'' hexamethyl, 2,4,6 Tris(dimethylamino) s triazine, admin, Altretamine, Altretamine chemical, Altretamine (product), Altretamine (substance), ALTRETAMINE PREPARATION, Hemel, Hexaloids, Hexamethyl melamine, hexamethylmelamine, HMM, HXM, N,N,N',N',N,N hexamethyl 1,3,5 triazine 2,4,6 triamine, N,n,n',NN hexamethyl 1,3,5, triazine 2,4,6, triamine, s Triazine 2,4,6 tris(dimethylamino), Brand name/Hexalen (Altretamine), Brand name/Hexastat (Altretamine), Brand name/HXM (Altretamine), Synonym/Hexamethylmelamine chemical name/admin'n, Synonym/HMM administration

Treatment

Drug Therapy - Contraindication

RX/Monoamine oxidase inhibitor

RX/Pyridoxine (Vitamin B6)

Drug Dosage

DRUG/.$$$$$ Most Expensive

DRUG/Oral medication (ex)

Definition

Primarily an Antineoplastic cancer chemotherapy drug. Alkylating agents interferes with methylation of DNA in mitosis, inhibits cell division. Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression often.

(Edit)

External Links Related to Altretamine (HMM/Hexalen) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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