Disease Information for Aliskiren (Tekturna) Administration/Toxicity

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Associated Diseases & Rule outs
Associated Disease & Complications
Drug induced Hyperkalemia
Disease Mechanism & Classification
Drugs
DRUG/Antihypertensive medication (examples)
Drug/Binds S3bp Renin pocket
DRUG/New release 2007
Drug/Novel Anti-Renin Effect
DRUG/Novel drug/Class
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
administration, Aliskiren (Tekturna), Brand name/Tekturna (Aliskiren), Brand name/Tekturna HCT (Aliskiren/HCT), Brand name/Valturna (Aliskiren/Valsartan)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/Dose 150 mgms (Unit/Pill/Capsule size)
DRUG/Dose 300 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Oral medication (ex)
Definition

New class of anti-hypertensive drug claimed to be more a direct Renin inhibitor that ARB/receptor blocker or ACE inhibitor; It can cause angioedema and hyperkalemia, especially if used with ACE inhibitor drug; As effective as Valsartan according to FDA studies; 150 mgm and 300 mgm tabs daily not with fatty meal; a Novartis product; Ketoconazole, Atorvastatin, and Irbesartan change the absorption C-max; Back pain, URI, dizzyness, fatigue, cough, headache and diarrhea occur; 2007

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External Links Related to Aliskiren (Tekturna) Administration/Toxicity
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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