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Disease Information for Alendronate (Fosamax) Administration/Toxicity
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Drug induced Esophagitis
- Drug induced Hypocalcemia
- Esophagitis
- Hypocalcemia
- Jaw necrosis/mandible
- Osteoradionecrosis Jaw
- Disease Mechanism & Classification
- Drugs
- DRUG/Bisphosphonate drug (example)
- Pathophysiology
- Pathophysiology/Osteoclast inhibition
- Process
- PROCESS/Medication/Drug (CONFIRM dose/before treatment)
- Synonyms
- Synonym
- 4 Amino 1 Hydroxybutylidene 1,1 Biphosphonate, admin, AHBUTBP, alendronate, Alendronate (substance), ALENDRONATE PREPARATION, Aminohydroxybutane Bisphosphonate, Bisphosphonate Aminohydroxybutane, Brand name/Fosamax (Alendronate)
- Treatment
- Drug Dosage
- DRUG/.$$$ Expensive medication
- DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
- DRUG/Dose 40 mgm (Unit/Pill/Capsule size)
- DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
- DRUG/Dose once daily (RX)
- DRUG/Dose Weekly
- DRUG/Oral medication (ex)
- Definition
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Bisphosphonate drug inhibits osteoclast activity; used in Paget"s bone disease and osteoporosis; oral preparation-----------------
Alendronate , 20–40 mg orally daily (or 70 mg orally once weekly) for 3-month cycles, is also effective. It must be taken in the morning, at least ½–1 hour before breakfast. Its main side effect is esophagitis, so recumbency after dosing is prohibited, and the drug is contraindicated in patients with a history of esophagitis, esophageal stricture, dysphagia, hiatal hernia, or achalasia. [currentdxrx 2005 accessmedicine.com]
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- External Links Related to Alendronate (Fosamax) Administration/Toxicity
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- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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