Disease Information for Alendronate (Fosamax) Administration/Toxicity

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Associated Diseases & Rule outs
Associated Disease & Complications
Drug induced Esophagitis
Drug induced Hypocalcemia
Esophagitis
Hypocalcemia
Jaw necrosis/mandible
Osteoradionecrosis Jaw
Disease Mechanism & Classification
Drugs
DRUG/Bisphosphonate drug (example)
Pathophysiology
Pathophysiology/Osteoclast inhibition
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
4 Amino 1 Hydroxybutylidene 1,1 Biphosphonate, admin, AHBUTBP, alendronate, Alendronate (substance), ALENDRONATE PREPARATION, Aminohydroxybutane Bisphosphonate, Bisphosphonate Aminohydroxybutane, Brand name/Fosamax (Alendronate)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
DRUG/Dose 40 mgm (Unit/Pill/Capsule size)
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Dose Weekly
DRUG/Oral medication (ex)
Definition

Bisphosphonate drug inhibits osteoclast activity; used in Paget"s bone disease and osteoporosis; oral preparation-----------------

Alendronate , 20–40 mg orally daily (or 70 mg orally once weekly) for 3-month cycles, is also effective. It must be taken in the morning, at least ½–1 hour before breakfast. Its main side effect is esophagitis, so recumbency after dosing is prohibited, and the drug is contraindicated in patients with a history of esophagitis, esophageal stricture, dysphagia, hiatal hernia, or achalasia. [currentdxrx 2005 accessmedicine.com]

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External Links Related to Alendronate (Fosamax) Administration/Toxicity
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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