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Disease Information for AIDS Dementia

Clinical Manifestations

Signs & Symptoms

Failure to Thrive

Cognitive defect

Developmental milestones delayed

Executive function loss/apathy/inertia

Paucity of ideas/conversation

Rapidly progressive dementia

Short term memory loss

Hallucination/visual

Low Frustration tolerance Adult

Poverty of thought

Urinary Incontinence in Elderly

Constitutional symptoms

Clinical Presentation & Variations

AIDS with Altered Mental State

AIDS with Neurologic Manifestations

HIV AIDS with Cognitive Decline

Disease Progression

Course/Chronic disorder

Laboratory Tests

Microbiology & Serology Findings

SALIVA Rapid HIV antibody test/abnormal

SUDS test (Rapid HIV antibody)/blood positive (labs)

URINE Rapid HIV antibody test/abnormal

Microlab/PCR CSF antigen/abnormal

Abnormal Lab Findings (Non Measured)

Right Shift (Viral) Differential Smear (Lab)

CSF Immunoelectrophoresis abnormal

Abnormal Lab Findings - Increased

HIV/Viral RNA/Plasma copies/quantitative (Lab)

CSF IGG

CSF Oligoclonal banding immunoelectroelectrophoresis

CSF/Beta 2 Microglobulin

Associated Diseases & Rule outs

Rule Outs

Alcohol amnestic disorder

Cryptococcal meningitis

Normal pressure hydrocephalus

Associated Disease & Complications

AIDS Dementia

Amnesia

CNS disease/involvement

Secondary Psychosis/Symptomatic

Ineffective Cough or Reflex

Disease Mechanism & Classification

Specific Agent

AGENT/Virus (category)

Class

CLASS/Neurologic (category)

Pathophysiology

Pathophysiology/Cytokine gene polymorphism

Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)

Process

PROCESS/Complicating/Specific process disorder (ex)

PROCESS/Infection/agent specific (category)

Definition

A neurologic condition associated with the HIV/aquired immune deficiency syndrome and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system; Pathologic examination of the brain reveals white matter rarefication, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells;(From Adams, Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)

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External Links Related to AIDS Dementia

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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