Disease Information for Acute Postinfectious Cerebellitis

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Clinical Manifestations
Signs & Symptoms
Acute ataxia
Ataxia
Ataxia, Cerebellar type
Ataxia/Motor tremor type
Awkward Uncoordinated Child
Involuntary Leg Movement Standing
Limb Ataxia
Limb ataxia/clumsiness child
Staggering Gait
Clinical Presentation & Variations
Presentation/Ataxia in a Child Acute
Disease Progression
Course/Few days
Course/Prolonged/Protracted convalescence
Course/Self limited usually
Onset/Acute
Prognosis/Full recovery usual
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Children/all
Population/Preschool child
Laboratory Tests
Microbiology & Serology Findings
Serum specific antibodies increased
Varicella-Zoster antibody levels (labs)
Epstein-Barr Virus/antibody titer (Lab)
Abnormal Lab Findings - Increased
CSF Cells
Associated Diseases & Rule outs
Rule Outs
Myoclonic encephalopathy/childhood
Neuroblastoma
Associated Disease & Complications
Acute Postinfectious cerebellitis
Cerebellar ataxia
Ataxia Disorder
Demyelinating Disease
Disease Mechanism & Classification
Class
CLASS/Cerebellar disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Ataxia worst at onset
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Autoimmune disorder (ex)
PROCESS/Post-infectious disorder (ex)
PROCESS/Inflammatory/autoimmune neuropathy process
Treatment
Drug Therapy - Indication
RX/No Treatment needed/usually symptomatic only
Other Treatments
TX/Plasmapheresis/exchange.
Definition

Acute Postinfectious Cerebellitis; Acute postinfectious cerebellitis is characterized by rapid onset of ataxia usually following a varicella infection, but other viral infections such as measles, mumps and Coxsackie-B have also been implicated; Postvaricella cerebellitis usually affects preschool and elementary school age children; It begins approximately 2 weeks after the onset of the viral illness, often after the vesicles begin to clear, and evolves rapidly over 2 to 3 days; Rarely, ataxia may be concomitant with or precede a skin rash; Gait is prominently affected and ataxia varies from mild unsteadiness to complete inability to stand or walk; the child is otherwise normal; CT scan and MRI of the head are usually normal in isolated acute ataxia; CSF is normal except for a possible mild pleocytosis. It is a self-limited disease with excellent prognosis and complete recovery in the vast majority of the children; R/O GBS and Millard Fischer Syndromes and Paraneoplastic Disorders

A relatively acute onset ataxia associated with opsoclonus (rapid chaotic conjugate eye movements) and myoclonus (violent jerking of the limbs on attempted movements) should suggest the possibility of neuroblastoma; The association of eye and limb jerking has been termed "dancing eyes, dancing feet syndrome" The tumor is often thoracic in location, but may be found in other regions such as the abdomen and pelvis; Diagnosis can be confirmed by CT or MRI of the chest and abdomen, and elevated urinary catecholamines (homovanillic acid - HVA and vanillylmandellic acid - VMA); Similar syndromes may be seen following viral infections and may respond to ACTH or steroid treatment-[pediatric neurology partel Indianapolis 2006]-----

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External Links Related to Acute Postinfectious Cerebellitis
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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