Disease Information for Acute disseminated encephalomyelitis

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Clinical Manifestations
Signs & Symptoms
Abnormal movements/involuntary
Coma/infant or newborn
Delirium
Delirium/Agitated delirium
Drowsiness/somnolence
Hyperreflexia/DTRs increased
Irritability/short tempered
Monoplegia, arm
Monoplegia, leg
Multifocal neurologic deficit/signs
Paralysis
Rapidly progressive dementia
Transient limb paralysis/palsy
Arthritis with Fever
Acutely ill patient/signs
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Hypersomnia/Increased need for sleep
Clinical Presentation & Variations
Presentation/Acute encephalopathy Child
Presentation/Encephalitis Rapidly Progessive
Disease Progression
Course/Acute
Course/Acute only
Course/Catastrophic presentation/onset
Course/Potentially lethal/untreated
Lethal Potential
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Increased
CSF Cells
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
Pathology
PATH/Brain/Capillary dilatation/inflammation/hemorrhage
PATH/Brain/Hemorrhagic foci
PATH/Brain/Leptomeningeal Lesions
PATH/Brain/multifocal lesions/cysts/grey and white matter
CT Scan
MRI/Head Demyelination white matter
MRI/Head Grey matter degeneration
MRI/Head White matter lesions
Associated Diseases & Rule outs
Associated Disease & Complications
Acute disseminated encephalomyelitis/syndrome
CNS disease/involvement
Coma in Children
Coma/Unconscious
Death Outcome
Encephalitis
Encephalomyelitis, acute
Myelitis
Myelopathy manifestations/involvement
Optic neuritis
Paraplegia
Demyelinating Disease
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Cerebral demyelination
Pathophysiology/Demyelination
Process
PROCESS/Acute infection (ex).
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Inflammatory/Allergy/immune (ex)
PROCESS/Inflammatory/infection (ex)
PROCESS/CNS/White matter disorder (ex)
Synonyms
Synonym
ACUTE DISSEM ENCEPH, Acute dissem encephalomyelitis, acute disseminated encephalitis, Acute Disseminated Encephalomyelitides, acute disseminated encephalomyelitis, Acute disseminated encephalomyelitis (disorder), ADEM Acute disseminated encephalomyelitis, ADEM Acute dissem encephmlts, DISSEM ENCEPH ACUTE, Disseminated Encephalomyelitides Acute, Disseminated Encephalomyelitis Acute, ENCEPH ACUTE DISSEM, ENCEPHALITIS ACUTE DISSEMINATED, Encephalomyelitides Acute Disseminated, encephalomyelitis acute disseminated, ENCEPHALOMYELITIS DISSEMINATED ACUTE, MYELINOCLASIS PERIVASCULAR ACUTE, Synonym/ADEM
Treatment
Drug Therapy - Indication
RX/Corticosteroid (Cortisone)
RX/Minocycline (Minocin)
Other Treatments
TX/Plasmapheresis/exchange.
Definition

An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination; Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified; Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements; The illness may progress to COMA and eventually be fatal; (Adams et al, Principles of Neurology, 6th ed, p921)

This may be the First attack of true multple sclerosis; repeat MRI in six months will help define this without a second attack clinically evident

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External Links Related to Acute disseminated encephalomyelitis
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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