Disease Information for Acrodermatitis, papular, infantile

Clinical Manifestations
Signs & Symptoms
Acrodermatitis/Rash Extremities and Face
Asymmetric rash/unilateral
Discreet Spots/dull red/blebs
Facial erythema
Facial rash
Foot Dermatitis
Foot rash
Lesions/rash extremities distribution
Non-pruritic rash
Papulosquamous Lesion
Papulosquamous rash
Rash hand/foot areas
Rash on extremities
Rash with well demarcated lesions
Rash/Characteristic pattern/distribution
Rash/upper arms
Vesicobullous rashes
Otherwise well Isolated problem
Clinical Presentation & Variations
Presentation/ Papular Rash Face Upper Arms
Disease Progression
Demographics & Risk Factors
Recent Event
Recent/Viral illness
Recent/Viral URI
Established Disease Population
Patient/Chronic active hepatitis
Population Group
Population/Pediatrics population
Sex & Age Groups
Population/Child-Infant Only
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Right Shift (Viral) Differential Smear (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Acrodermatitis, Papular, infantile
Papular acrodermatitis/childhood
Papular acrodermatitis/Hepatitis B syndrome
Viral exanthematous diseases
Disease Mechanism & Classification
Specific Agent
AGENT/Virus (category)
CLASS/Pediatric disorders (ex)
CLASS/Dermatologic/Subcutaneous (category)
CLASS/Digit disorder (ex)
CLASS/Extremities/Digits/Hand feet disorder (category)
CLASS/Muscle/tendon/extremities (category)
PROCESS/Complicating disorder (ex)
PROCESS/Inflammatory/infection (ex)
Acrodermatitides Infantile Papular, acrodermatitis infantile papular, Acrodermatitis papulosa infantum, Giannotti Crosti, Gianotti Crosti Syndrome, Gianotti Crosti syndrome (disorder), Gianotti Crosti syndrome RETIRED, Infantile papular acroderm, Infantile Papular Acrodermatitides, infantile papular acrodermatitis, Infantile papular acrodermatitis (Giannotti Crosti), Pap acroderm of childhood, Papular Acrodermatitides Infantile, Papular Acrodermatitis Infantile, Papular acrodermatitis of childhood, Syndrome Gianotti Crosti, Synonym/GCS Hepatitis B exanthem, Synonym/Gianotti-Crosti syndrome

Gianotti Crosti Syndrome; Acrodermatitis, Infantile Lichenoid; Acrodermatitis, Papular Infantile; Crosti-Gianotti Syndrome; GCS; Papular Acrodermatitis of Childhood;

Gianotti-Crosti Syndrome is a rare skin disease affecting children between the ages of nine months to nine years; Major symptoms may include blisters on the skin of the legs, buttocks and arms; The disorder is usually preceded by a viral infection;


Crosti syndrome, or papular acrodermatitis of childhood (PAC), is a self-limited childhood exanthem that manifests in a characteristic acral distribution; It is rarely associated with systemic findings; The original cases, described in Italy by Gianotti in 1955, were associated with hepatitis B virus infection, although other viral infections currently account for most cases; The 2 older, descriptive designations, PAC and papulovesicular acrolocated syndrome (PAS), described indistinguishable clinical entities ; PAC is the term most commonly used today;

The agents that have been reported in association with Gianotti-Crosti syndrome include Epstein-Barr virus (EBV), cytomegalovirus (CMV), respiratory syncytial virus (RSV), coxsackievirus and other enteroviruses, parainfluenza virus, parvovirus B19, poxvirus, human herpesvirus v 6 (HHV-6), rotavirus, human immunodeficiency virus, and group A beta-hemolytic streptococci.

Some occurrences have followed immunization with measles-mumps-rubella, hepatitis B, poliovirus, and influenza virus vaccines; Gianotti-Crosti syndrome likely represents a localized cutaneous inflammatory response to deposition of viral particles or bacteria within the dermis as a result of transient viremia or bacteremia; Deposition of immune complexes in the skin may also play a role; elevated levels of total and specific immunoglobulin E and a family history of atopy.


External Links Related to Acrodermatitis, papular, infantile
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)