Disease Information for Acetaminophen (Tylenol) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Palpable Liver/Hepatomegaly
Demographics & Risk Factors
Population Group
Status/College student/campus living
Young Adult
Sex & Age Groups
Population/Young adult
Laboratory Tests
Abnormal Lab Findings (Non Measured)
URINE Isosthenuria/mid-range SPGR
URINE Specific gravity fixed/1.010
Abnormal Lab Findings - Decreased
Glucose, blood (Lab)
Abnormal Lab Findings - Increased
URINE 5-Hyroxyindole acetic acid
Associated Diseases & Rule outs
Associated Disease & Complications
Acetamenophen (Tylenol) effect/toxicity
Acute hepatic necrosis/yellow atrophy
Chronic hepatitis/Active
Drug induced Hepatic toxicity
Drug induced Hypoglycemia
Drug induced Nephritis/Nephropathy
Hypoglycemia
Isosthenuria syndrome
Nephritis, analgesic/interstitial
Nephritis, interstitial
Nephritis, non-allergic interstitial
Nephritis, secondary
Pancreatitis, acute
Renal papillary necrosis
Toxic hepatitis
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Chronic Hepatitis
Disease Synergy - Causes
Risk factor/Alcohol ingestion
Risk factor/Alcoholism
Disease Mechanism & Classification
Drugs
DRUG/Analgesic/non-narcotic drug (example)
DRUG/Antiphlogistic/NSAIDS drug (category)
DRUG/Antipyetic/fever medication (ex)
DRUG/P450 metabolic pathway/competitor
DRUG/Safe in pregnancy patient (B)
DRUG/Toxic metabolite (NAPQI) benzoquinoneimine
DRUG/Toxic metabolites (example)
DRUG-Liver metabolism/bile excretion
DRUG/P450 cytochrome system/toxic metabolite
Pathophysiology
Pathophysiology/Defective Potassium excretion/renal
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Latency after exposure/ingestion
TOXIN/Poisoning delayed effect/8 hours
TOXIN/Slow curve fast break 24 hrs
Synonyms
Synonym
4 hydroxyacetanilide, Acetamide N (4 hydroxyphenyl), Acetamidophenol, Acetaminophen, Acetaminophen (product), Acetaminophen (substance), ACETAMINOPHEN PREPARATION, Acetaminophen product, Acetominophen, ACMP, APAP, Hydroxyacetanilide, N (4 Hydroxyphenyl)acetamide, N (4 Hydroxyphenyl)acetanilide, N Acetyl p aminophenol, p Acetamidophenol, p Hydroxyacetanilide, Paracetamol, Paracetamol chemical, Paracetamol (substance), Paracetamol product, Brand name/Anexia (Hydrocodone-Acetaminophen) comb, Brand name/Anexsia (Hydrocodone) combination, Brand name/Darvocet-N (Propoxephene-Acetaminophen), Brand name/Datril (Acetomenophen), Brand name/Duradrin (Isometheptine-Dichloralphenazone-Acetomenaphen), Brand name/Esgic (Butalbital-Acetaminophen-Caffeine), Brand name/Fioricet (Butalbital-acetamenophen), Brand name/Lorcet (Hydrocodone-Acetamenophen), Brand name/Lortab (Hydrocodone-Acetamenophen), Brand name/Maxidone (Hydrocodone/Acetaminophen), Brand name/Midrin (Dichloralphenazone-Isometheptene-Acetaminophen), Brand name/Norco (Hydrocodone/Acetamenophen) combination, Brand name/Panlor (Dihydrocodeine/Acetaminophen), Brand name/Percocet (Oxycodone-Acetaminophen), Brand name/Roxicet (Oxycodone) combination, Brand name/Talacen (Pentazocin-Acetamenophen), Brand name/Tylenol (Acetaminophen), Brand name/Tylenol Codeine combination, Brand name/Vicodin (Hydrocodone) combination, Brand name/Wygesic (Propoxyphen) combination, Brand name/Zydone (Hydrocodone) combination, Britain-BNF/Paracetamol (Acetaminophen), Synonym/Paracetamol (APAP/Para-aminophenol)
Treatment
Drug Therapy - Indication
RX/Acetylcysteine (Mucomist/NAC) (oral)
RX/N-Acetylcysteine (NAC) IV ?
Drug Dosage
DRUG/Dose PRN (as needed)
DRUG/Dose Rectal enema/suppository available
Definition

Analgesic over the counter medication; oral medication; wide usage, very popular; overdose causes hepatic necrosis

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External Links Related to Acetaminophen (Tylenol) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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