Disease Information for Accutane (ITR) embryopathy syndrome

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Clinical Manifestations
Signs & Symptoms
Particular physiognomy/Odd looking kids
Craniofacial Abnormalities/Congenital
Facial Asymmetry
Midfacial hypoplasia/flat face dysmorphism
Poor weight gain/child
Receding chin deformity
Uvula anomaly/deformity
Mental Deficiency Child
Asymmetric Limbs
Foot deformity
Lateral Asymmetry
Double Image Vision Confirmed
Narrow Palpebral Fissures
Clinical Presentation & Variations
Presentation/Multiple deformities newborn (odd look)
Diagnostic Test Results
CT Scan
MRI/Head Arachnoid/epidermoid cyst
X-RAY
Xray/Distal ulna/radius deformity
Xray/Hemivertebrae deformity/Spine
Associated Diseases & Rule outs
Associated Disease & Complications
Adrenal hypoplasia
Aortic arch congenital anomalies
Blind external ear canals/microtia deformity
Cataract
Cleft Lip
Cleft lip/deformity
Cleft palate/deformity
Clubbed foot/congenital
Coarctation of aorta
Cognitive/learning disability
Cortical blindness
Craniorachischisis/Neural tube defect
Craniosynostosis
Di George syndrome
Drug induced Potential fetal/anomaly
Facial paralysis of newborn
Femur/Femoral hypoplasia
Growth retardation/failure
Hydrocephalus
Hydroureter/congenital
Inguinal Hernia
Limb deformities/anomalies
Mental retardation
Micrognathia/congenital small chin
Microphthalmos
Ophthalmoplegia
Posterior cranial fossa cyst
Renal anomaly/aplasia/hypoplasia
Sirenomelia deformity
Spina bifida
Spina bifida occulta
Syndactyly/Webbing
Transposition great vessels
Ventricular septal defect
Vertebral anomalies
Hand anomalies
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Fetus disorder (ex)
Drugs
DRUG/Maternal medication/fetal effect
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Asymmetric deformities
Pathophysiology/Fetal Drug Effect Syndrome
Pathophysiology/Postaxial limb deficiency/phocomelia
Process
PROCESS/Multiple dysmorphic syndrome (ex)
PROCESS/Dystostosis/craniofacial (ex)
Synonyms
Synonym
Accutane (ITR) embryopathy syndrome, Synonym/Fetal Accutane Syndrome, Synonym/Fetal Isotretinoin syndrome, Synonym/Isotretinoin (ITR) dysmorphic syndrome, Synonym/Isotretinoin (ITR) Teratogen/Dysmorphic syndrome
Definition

Multiple fetal abnormalities due to the maternal use of vitamin A congeners in the treatment of recalcitrant severe acne during pregnancy; Birth defects are similar to those in Di George syndrome and include craniofacial and central nervous system anomalies with dysmorphic facial features, learning problems, cortical blindness, facial nerve paralysis, microtia, metopic synostosis, microphthalmia, and oculomotor paralysis; Associated abnormalities may include cardiovascular, thymic, spinal, urinary, and other defects--------[Jablonski/NIH Anomalies Archive]--------------most dangerous fetal exposure time two to five weeks after conception; abortion and fetal death is common with no intervention

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External Links Related to Accutane (ITR) embryopathy syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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