Disease Information for 3-Quinuclidinyl Benzilate/Weapons (QNB/BZ) agent

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Clinical Manifestations
Signs & Symptoms
Paroxysmal Shivering
Rigors/Shaking chills
Teeth Chattering
Uncontrollable Shaking
Brief Blood pressure increase/sign:
High blood pressure/sign
Tachycardia/Fast heart rate
Decreased sweating/Absent sweating
Facial erythema
Facial flushing/Beet red
Flushing
Flushing/upper body
Excessive thirst/polydipsia
Dry mouth/Mucous membranes
Foul breath
Halitosis
Hypertonia
Warm/Extremities dry/warm to touch
Active reflexes
Acute ataxia
Confusion/agitation on exam
Confusion/Disoriented
Delirium
Delirium/Agitated delirium
Hypereactive/on exam
Hyperreflexia/DTRs increased
Intoxicated state/ataxia/slurred speech
Slow speech
Slurred speech
Slurred Speech/Acute
Staggering Gait
Stupor/poor reponse to stimulus
Unable to tandem walk/straight line
Agitation
Fearful/Afraid
Hyperstimulated/Wakeful
Manic behavior
Psychotic behavior/symptomatic
Queer bizarre behavior/change
Short attention span
Hoarseness
Nasal irritation/dryness
Scratchy throat/Dry throat
Voice Alteration
Voice change/disturbance/Unusual
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Restlessness/Anxiousness
Thirst Increased
Dimming vision/acute
Dry eyes/poor tearing
Dryness Conjunctiva
Grainy/Gritty Eye Sensation
Mydriasis/wide pupils
Photophobia/Light sensitive
Temporary blindness
Disease Progression
Course/Acute
Course/Acute only
Demographics & Risk Factors
Exposure Factors
Exposure/Terrorist Chemical weapon agent
Exposure/Terrorist/Chemical-biological weapon (CBW)
Occupational Factors
Occupation/Soldier/officer military
Event, Activity, Behavioral & Seasonal Factors
Event/Mass exposure/community illness/death
Event/Warfare/Combat status/effects
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Anhydrosis/Absent sweating/diffuse
Anticholinergic/belladonna group toxidrome
Chemical Tracheobronchitis
Hallucinations
Hyperpyrexia
Hypertension
Hyperthermia
Laryngeal edema
Paranoia reaction
Sedation/torpor induced
Tracheal edema
Urinary bladder retention
Ataxia Disorder
Disease Mechanism & Classification
Process
PROCESS/Poison/specific (category)
Toxin
TOXIN/ Onset One hour
TOXIN/Aerosolized Terror/Weapon chemical
TOXIN/Causes Flushing/Redness
TOXIN/Causes Hyperthermia/Fever
TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
TOXIN/CBW Military chemical Incapacitant/non-lethal
TOXIN/Chemical Weapon/Terrorist/Military
TOXIN/Cleared by kidney/Urine
TOXIN/Dry as a bone/mouth/eyes/nose
TOXIN/Incapacitating weapon agent (ex)
TOXIN/Lethal possible
TOXIN/Poison Organic (category)
TOXIN/Prolonged effect two days plus
TOXIN/Toxidrome/poisoning pattern (ex)
TOXIN/Weapon/anti-personnel agent/poison (ex)
Synonyms
Synonym
Benzeneacetic acid alpha hydroxy alpha phenyl 1 azabicyclo(2 2 2)oct 3 yl ester, Benzilate Quinuclidinyl, Quinuclidinyl Benzilate, Synonym/BZ (3-Quinuclidinyl Benzilate) agent, Synonym/QNB (3-Quinuclidinyl benzilate) exposure
Treatment
Drug Therapy - Indication
RX/Physostigmine
Other Treatments
TX/Expectant/supportive treatment.
Definition

Also called QNB or BZ; Incapacitating agent/chemical weapon; often not lethal but powerful anti-cholinergic agent with hallucinagenic properties; aerosol delivery respiratory intake but can be absorbed through skin; toxidrome is like atropine but very long acting; there is no odor; syndrome is: " dry as a bone, blind as a bat, red as a beet, hot as a hare, and mad as a hatter"

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External Links Related to 3-Quinuclidinyl Benzilate/Weapons (QNB/BZ) agent
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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