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Disease Comparison Results (show differences mode) for Paroxysmal Nocturnal Hemoglobinuria and Renal Failure Acute

Clinical
Demographics
Lab
Diagnostic
Diseases
Classification
Synonyms
Treatment
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Found: 196 | Differences: 187

Found: 214 | Differences: 205

Paroxysmal Nocturnal Hemoglobinuria and Renal Failure Acute sharing 8 common findings. (show all, show common, show differences)

Clinical Manifestations
Signs & Symptoms: Edema Children; Facial edema/swelling; Diastolic hypertension; Fluid retention/Mild edema; High blood pressure/sign; Tachycardia/Fast heart rate; Beau's lines/Mees lines fingernails; Bruising/Ecchymosis; Nail Striations; Petechiae/Petechial rash; Pruritis Itching; Excessive/easy bruising tendency; Anorexia Decreased appetite; Hiccough/Hiccups; Nausea; Vomiting; Breath odor of Ammonia; Characteristic breath odor; Dry mouth/Mucous membranes; Metallic taste; Liver flap tremor/Asterixis; Chvostek's sign; Cramping in Extremities; Muscle fasciculations; Muscle twitches; Muscle weakness; Twitchy/muscle spasms; Weak/Weak as a kitten (symptom); Altered Mental State Diabetic; Altered mental status Mental status change; Confusion/agitation on exam; Confusion/Disoriented; Fatigability; Infant Seizures; Lethargy/torpor; Myoclonus/Myoclonic jerks on exam; Obtunded/poorly responsive status/signs; Seizures; Seizures/Children/recurrent; Stupor/poor reponse to stimulus; Sudden unconsciousness; Weakness/Diffuse motor loss; Hyperpnea; Rapid Breathing; Tachypnea/Increased respiratory rate; Chronic Back Pain; Epistaxis, severe/persistent; Anuria; Breath odor of Stale fish; Oliguria/Decreased urine output; Oliguria/sudden; Uremic fetor; Acutely ill patient/signs; Chronic Fatigue; Enervated/extreme acute fatigue; Fatigue Tiredness Exhaustion; Neonatal edema/anasarca; Weakness; Weakness non-neuromuscular/systemic; Weight gain; Weight Loss; Eyelid Fasciculations; Retinopathy signs on exam
Clinical Presentation & Variations: Presentation/Hypertension Abrupt Onset; Presentation/Diabetic Decreased need for Insulin
Disease Progression: Course/Acute; Course/Acute only; Course/Potentially lethal/untreated; Lethal Potential

Demographics & Risk Factors
Established Disease Population: Patient/Bacterial endocarditis; Patient/Preeclampsia/toxemia; Patient/Shock status; Patient/Severe/extensive Burns; Patient/Glomerulonephritis, acute

Laboratory Tests
Abnormal Lab Findings (Non Measured): Hyperprolactinemia; Osmotic gap (low Na/high osmolality) (Lab); Renal function abnormalities (Lab)
Abnormal Lab Findings - Decreased: Aspartamine aminotransferase (SGOT, AST) (Lab); Bicarbonate, serum (Lab); Calcium, serum (Lab); Carbon Dioxide Total Content/CO2; Creatine clearance (Lab); Lymphocytes (Lab); PCO2, arterial blood (Lab); pH, arterial blood (Lab); Sodium, serum (Lab); URINE Osmololality; URINE Potassium
Abnormal Lab Findings - Increased: Acute lymphopenia/transient; Brain Natiuretic Peptide/BNP level (Lab); BUN/Blood urea nitrogen (Lab); Creatinine, serum (Lab); Digoxin serum level (Lab); Fibrin Degredation Product (FDP) (Lab); Fibrin Split Products/FSP/Dimers/Monomers (Lab); Fibrinopeptide A; FibrinPeptide A; Free fatty acids/FFA/Non-esterified (Lab); Gastrin, serum (Lab); Glucagon (Lab); Growth hormone/STH, plasma (Lab); Lactic acid/Lactate (Lab); Lipase (Lab); Magnesium (Lab); NT-proBNP indicator levels (N-terminal); Phosphate Serum (Lab); Potassium, serum (Lab); Prolactin (Lab); Sodium, serum (Lab); Sulfate, serum (Lab); Triglyceride lipase (Lab); Uric acid, serum (Lab); URINE Glucuronidase, beta; URINE Growth hormone; URINE Hexosaminidase; URINE Protein (Albumin)

Diagnostic Test Results
Isotope Scan: Isotope/DMAS Kidney Scan Abnormal
EKG (ECG): EKG/Prolonged QT interval (ECG); EKG/Prolonged QT/Peaked T Waves (ECG)
X-RAY: Xray/Chest abnormal; Xray/Congestive heart failure signs/Chest; Xray/Chest/Lung fields/Abnormal; Xray/Lung consolidation/Chest
X-RAY With contrast: IVP/Decreased dye visualization/bilateral; IVP/Dense nephrogram, bilateral

Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs: Hyperkalemic periodic paralysis; Myxedema coma
Associated Disease & Complications - Causes: Acidosis; Acidosis, metabolic; Acute anuria/renal failure; Azotemia in Children; Azotemia in Elderly; Azotemia/Acute; Congestive heart failure; Convulsions (grand mal); Death Outcome; Digitalis toxicity/poisoning; Gastrointestinal bleeding; Hallucinations; Hyperkalemia; Hypermagnesemia; Hypernatremia; Hyperphosphatemia; Hypertension; Hyperuricemia; Hypervolemia; Hypocalcemia; Hypocapnea/hypocarbia; Hyponatremia; Intravenous pyelogram CONTRA-INDICATED/DANGER; Lactic acidosis; Lymphocytopenia; Metabolic Acidosis with High Anion Gap; Metabolic encephalopathy; Pneumonia, pneumococcal; Pneumonia, staphylococcus; Potassium administration/effect/toxicity; Proteinuria; Retinopathy; Sideroblastic Anemia Sideroachrestic; Xerostomia; Hypergastrinemia
Disease Synergy: Synergy/Digitalis/digoxin toxicity; Synergy/On medications/medication; Synergy/Salt load/high sodium diet

Disease Mechanism & Classification
Class: CLASS/Renal/kidney involvement/disorder (ex); CLASS/Urologic (category)
Pathophysiology: Pathophysiology/Blood volume/increase/high; Pathophysiology/Alveolar consolidation; Pathophysiology/Decreased glomerular filtration; Pathophysiology/Salt/water retention, renal
Process: PROCESS/Complicating disorder (ex); PROCESS/Non-hereditary metabolic disorder (ex)

Synonyms
Synonym: Synonym/ARF; Synonym/Azotemia

Treatment
Drug Therapy - Contraindication: RX/Diuretic; RX/Magnesium oxide; RX/Potassium-sparing diuretic
Other Treatments: TX/Dialysis.; TX/Fluid restriction; TX/Medical emergency

Clinical Manifestations
Signs & Symptoms: Paroxysmal Shivering; Rigors/Shaking chills; Teeth Chattering; Uncontrollable Shaking; Abdominal pain Radiates to Back; Recurrent Abdominal Pain; Stroke Syndrome Child; Mid-back pain; AM dark urine/on awakening; Coca-Cola dark (coffee colored) urine; Costovertebral Angle Pain/Tenderness; Dark urine; Flank Pain; URINE Color Red; Massive splenomegaly; Splenomegaly; Chills; Nocturnal awakenings Events Phenomenon; Otherwise well Isolated problem; Pallor
Clinical Presentation & Variations: Presentation/Deep Vein Thrombosis Young Recurrent; Presentation/Anemia Refractory; Presentation/Refractory iron deficiency anemia
Disease Progression: Course/Attacks Episodic Spells; Course/Chronic disease crisis/flare/attacks; Course/Chronic disorder; Course/Chronic only; Course/Episodes last 1 to 3 weeks/remit recur months later; Course/Paroxysmal; Course/Periodic Episodic; Course/Prognosis bad/usually; Pancytopenia with Hypercellular Marrow; Pancytopenia with Normal Marrow

Demographics & Risk Factors
Population Group: Child; Population/Pediatrics population
Family History: Family history/Anemia
Sex & Age Groups: Population/Adult ('twenties'); Population/Adult Aged Only; Population/Adult/all; Population/Child; Population/Children/all; Population/Male

Laboratory Tests
Microbiology & Serology Findings: Reticulocytosis
Abnormal Lab Findings (Non Measured): Cytogenetics Abnormal; Acid hemolysis test (Ham) positive (Lab); Chromosomal abnormality (Lab); Coombs negative hemolytic anemia (Lab); Flow cytometry tests/abnormal (Lab); Flow Cytometry/CD55 and CD59 defects (Lab); Indirect bilirubin inc/normal direct bil. (Lab); Leukopenia; Microcytes/small RBCs on Blood smear; Microcytosis/microcytic anemia (Lab); Normocytic anemia; Normocytic Anemia/High Retic count; Normocytic/Normochromic Anemia (Lab); PI-linked Antigen (Cd14/CD59) positive; Sucrose-water hemolysis test/abnormal (Lab); URINE Color Brown; URINE Dipstick /Blood abnormal
Abnormal Lab Findings - Decreased: Ferritin, serum (Lab); Hematocrit (Lab); Hemoglobin (Lab); Iron, serum (Lab); Leukocyte Alkaline phosphatase (Lab); MCV/Mean Corpuscular Volume (Lab); Platelet survival (Lab); RBC/Red Blood Count (Lab)
Abnormal Lab Findings - Increased: Bilirubin, serum (Lab); C3, serum (Lab); Fetal hemoglobin (Lab); Free hemoglobin, plasma (Lab); Indirect bilirubin (Lab); Lactic Dehydrogenase (LDH LH) (Lab); Leukocyte Alkaline phosphatase (Lab); Methemalbumin (Lab); Osmotic fragility, RBC (Lab); Platelet Antibody Detection; Polychrome RBCs (Lab); RBC Actylcholinesterase level (Lab); Reticulocytes (Lab); Spherocytes (Lab); TIBC/Total Iron Binding capacity (Lab); URINE Hemoglobin; URINE Hemosiderin; URINE Red blood cells; URINE Urobilinogen; STOOL Urobilinogen

Diagnostic Test Results
Pathology: Bone Marrow/Erythroid hyperplasia; Bone Marrow/Hypercellular; Bone Marrow/Normoblasts hyperplasia; BX/Renal hemosiderosis; PATH/Erythrophagocytosis/Spleen

Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs: Hemolytic anemia/autoimmune; Myelodysplasia
Associated Disease & Complications - Causes: Acute Myelogenous/Myeloblastic Leukemia AML; Acute Tubular Necrosis; Anemia; Anemia, aplastic; Anemia, severe; Arterial Occlusion; Bilirubinemia; Bone Marrow Fibrosis; Brisk Hemolysis/Active; Cavernous sinus thrombosis; Cerebral thrombosis; Cerebral vein thrombosis/phlebitis; Cholelithiasis; Disseminated intravascular coagulation; Folic acid deficiency anemia; Hemoglobinuria; Hemolysis anemia/acute/active; Hepatic vein thrombosis (Budd-Chiari); Hypercoagulability/Thrombophilia; Iron deficiency anemia; Leukemia; Mesenteric vein thrombosis; Myelodysplasia; Myelofibrosis; Myelofibrosis secondary; Pancytopenia; Paroxysmal nocturnal hemoglobinuria; Phlegmasia cerulea dolens; Portal vein thrombosis; Priapism/persistent erection; Pulmonary embolism; Pulmonary infarction; Purpura fulminans; Raynaud's syndrome; Renal Failure Chronic; Stroke/Child; Thrombocytopenia; Thrombocytopenia in Children; Thrombocytopenia in Elderly; Thromboembolic disease; Thrombophlebitis Arm/Deep Vein; Thrombophlebitis, deep vein; Thrombosis, arterial; Thrombosis, renal vein; Phlebitis, recurrent; Hypercoaguability
Disease Synergy: Synergy/Immunizations/vaccinations; Synergy/Infection; Synergy/Iron ingestion/administration; Synergy/Menses trigger

Disease Mechanism & Classification
Class: CLASS/Primary organ/system disorder (ex); CLASS/Erythrocyte disorder (ex); CLASS/Hematologic (category); CLASS/Stem cell disease (ex)
Pathophysiology: Pathophysiology/Chromosome gene/segment deletion (ex); Pathophysiology/Gene locus Chromosome X.; Pathophysiology/Gene Locus Identified/OMIM database; Pathophysiology/Gene locus PIG-A gene /X-chromosome; Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations); Pathophysiology/Arterial Occlusion; Pathophysiology/Thrombosis veins lower ext/iliac/femoral; Pathohysiology/PIGA defect/GPI Membrane Anchor fails; Pathophysiology/Chronic Iron loss; Pathophysiology/Complement sensitivity; Pathophysiology/Erythrocyte membrane disorder; Pathophysiology/Hemolysis; Pathophysiology/Hemolytic process/effect; Pathophysiology/Intrinsic CO production increased; Pathophysiology/Myelodysplasia process; Pathophysiology/Non-immune hemolytic anemia; Pathophysiology/Plasma c3b inactivatior/failure; Pathophysiology/RBC membrane defect/complement risk; Pathophysiology/RBC membrane glycosyl-phosphatidyl-inositol path; Pathophysiology/RBC membrane/Missing key proteins; Pathophysiology/Stem cell defect; Pathophysiology/Unusual sensitive RBC to C3 in plasma; Pathophysiology/Complement activation; Pathophysiology/Granulocyte lyses/manifestation
Process: PROCESS/Allergy/collagen/autoimmune (category); PROCESS/Episodic disorder (ex); PROCESS/Hereditofamilial (category); PROCESS/Idiopathic/unclassified/unknown (category); PROCESS/INCIDENCE/Acquired disorder; PROCESS/INCIDENCE/Rare disease (ex); PROCESS/Pre-Leukemic condition (ex); PROCESS/Coagulation derangement/disorder (ex); PROCESS/Somatic mutation/not hereditary

Synonyms
Synonym: Synonym/Marchiafava-Micheli syndrome; Synonym/PNH

Treatment
Drug Therapy - Contraindication: RX/Oral contraceptive
Drug Therapy - Indication: RX/Blood transfusion/packed cells; RX/Eculizamab (Soliris); RX/Folic/Folinic acid (Leukovorin); RX/Iron/Ferrous Sulfate (Feosol); RX/Prednisone (Deltasone); SX/Bone marrow transplant; SX/Stem cell transplant/allogenic; SX/Stem-cell transplant
Other Treatments: TX/Platelet transfusion

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