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Disease Comparison Results (show differences mode) for Multiple Sclerosis and Raynaud's disease

Clinical
Demographics
Lab
Diagnostic
Diseases
Classification
Synonyms
Treatment
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Raynaud's disease

Found: 113 | Differences: 98

Multiple Sclerosis

Found: 452 | Differences: 437

Multiple Sclerosis and Raynaud's disease sharing 15 common findings. (show all, show common, show differences)

Clinical Manifestations
Signs & Symptoms: Acrocyanosis/Cyanosis extremities; Allen maneuver/test abnormal; Decreased peripheral pulses; Digital pallor/vasospasm; Digital ulceration/fingertips; Dorsalis pedis pulse decreased; Regional pallor/vasospasm; Unilateral hand/fingers cold/pale; Vasospasm of extremities/Signs; White/blanching area discoloration; Beau's lines/Mees lines fingernails; Cold exposed areas/purpuric lesions; Excess Sweating Children; Finger Lesions; Fingernails brittle/thinner/splitting; Hyperhidrosis/local (extremity); Koilonychia/Spoon nails; Mottled legs; Nail Striations; Ulceration fingertips; Yellow nails; Arm Pain; Cold hands/fingers and toes; Cool extremities; Cyanotic extremity; Edema/hands and feet; Extremity pale/cold/numb/painful; Finger Pain; Finger tips/painful/tender; Hand Pain and Swelling Unilateral; Hand Pains; Inflammatory Finger Lesion; Multiple Digits Painful; Numbness of feet; Pain in Extremities/Melalgias; Painful finger pads; Painful/finger tips; Palmar Edema; Palmar Swelling; Sweating palms; Toe pains; Unilateral Palmar Swelling; Upper extremity pains; Numbness/distal fingers and toes; Numbness/hands; Blue nailbeds; Tobacco Habit/Excess; Foot Pain; Hand pain and swelling bilateral; Midfoot pain; Apparently well Silent disorder possible
Disease Progression: Course/Indolent

Demographics & Risk Factors
Ethnic or Racial Factors: Arab/population
Sex & Age Groups: Population/Adult ('twenties')

Laboratory Tests
Abnormal Lab Findings: Anti-RNP (U1RNP) antibody (Lab); Anti-SCL-70 (antinucleotide) (Lab); ANA/Anti-centromere antibody (Lab)

Diagnostic Test Results
Other Tests & Procedures: Extremity Plethsmography Abnormal; Plethysmography Arterial Abnormal; TEST/Plethysmography/extremities abnormal
X-RAY: Xray/Calcified artery/veins finding; Xray/Calcification in fingertips; Xray/Distal Phalanges Tuft Resorption
Ultrasound: Echo/Pulmonary artery hypertension

Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs: Peripheral arterial blockage/limb ischemia; Reflex sympathetic dystrophy/Sudeck's atrophy
Associated Disease & Complications - Causes: Acrosclerosis; Arterial Occlusion; Frostbite; Myocardial infarction, acute; Pulmonary hypertension; Raynaud's disease; Raynaud's syndrome; Toe Ulcer
Disease Synergy: Synergy/Cold environment; Synergy/Cold water/drinking/washing exposure trigger; Synergy/Tobacco smoking

Disease Mechanism & Classification
Class: CLASS/Primary organ/system disorder (ex); CLASS/Arteriolar disorder (ex); CLASS/Cardiovascular (category); CLASS/Small artery disorder; CLASS/Vascular disorder (ex).; CLASS/Vascular Small Vessel Disorder; CLASS/Digit disorder (ex); CLASS/Extremities/Digits/Hand feet disorder (category)
Pathophysiology: Pathophysiology/Arterial Occlusion; Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis; Pathophysiology/Small Vessel Vasculitis; Pathophysiology/Vasospastic dysfunction
Process: PROCESS/Eponymic (category); PROCESS/Idiopathic/unclassified/unknown (category); PROCESS/Vegetative-Autonomic/Endocrine (category)

Synonyms
Synonym: Synonym/Primary Raynauds (Disease)

Treatment
Drug Therapy - Contraindication: RX/Propranolol (Inderal)
Drug Therapy - Indication: RX/Hydralazine (Apresoline); RX/Nifedipine (Procardia); RX/Prazosin (Minizide); SX/Sympathectomy

Clinical Manifestations
Signs & Symptoms: Face Pain; Numbness of face; Anesthetic area/skin; Anorgasmic male; Loss of libido,male; Retrograde ejaculation; Sexual dysfunction; Anal sphincter/loss of tone/reflex; Bowel/Stool Incontinence; Bowel/stool incontinence in Children; Dysphagia Swallowing Difficulties; Problems with defecation; Decreased taste ability/Hypoguesia; Numbness of tongue; Acute Motor Weakness; Hypertonia; Twitchy/muscle spasms; Unilateral arm symptoms; Unilateral Leg Weakness; Weak/Weak as a kitten (symptom); Weakness, legs, bilateral; Weakness/one arm; Abdominal reflex decreased; Abdominal reflex increased; Abnormal movements/involuntary; Active reflexes; Acute ataxia; Altered mental status Mental status change; Ankle reflexes increased; Aphasia; Arm vibratory sense decreased; Ataxia; Ataxia/Posterior columns; Attacks, neurologic, recurrent, varied; Babinski's up-going toe reflex/unilateral; Babinski's upgoing toes/bilateral; Behavior problems; Bilateral abdominal reflex decreased; Central Facial Paralysis; Cerebellar signs; Clonus; Clonus/bilateral ankle (sustained); Clumsiness/poor coordination; CNS symptoms/signs; Cognitive defect; Confusion/agitation on exam; Confusion/Disoriented; Conjugate gaze paralysis; Coordination/signs; Cranial nerve abnormalities/involvement/signs; Daytime Sleepiness; Delirium; Dizziness/Dizzy; Double vison after vigorous exercise; Dropping things; Dysarthria; Dysconjugate gaze; Dysdiadochokinesia/Alternating failure; Dysphasia; Equinus Posture/Ankles; Extinction parietal/sensory two touch sign; Facial Nerve Palsy/Facial Paralysis; Facial weakness/droop, unilateral; Fatigability; Fine-motor coordination problems; Finger to nose test abnormality; Focal neurologic deficit; Gait disturbance/abnormality; Hand paralysis; Handwriting progressive decline; Hemianesthesia; Hemianopsia/homonymous/sign; Hemiplegic Gait; Hemisensory defects; Hot bath worsens neurologic symp/signs; Hyperreflexia/DTRs increased; Impaired judgement/signs; Inattention; Leg reflexes increased; Legs increased resistance/passive stretch; Legs increased tone/spastic/hyperreflexic; Lhermittes sign (tingling on neck flex); Limb weakness/signs; Long tract signs; Loss of Taste; Monoplegia, arm; Monoplegia, leg; Multifocal neurologic deficit/signs; Multiple paralysis/multiplegia, assymetric; Neurologic manifestations/signs; Neurological symptoms/signs; Numbness/one-sided; Nystagmus; Nystagmus, Monocular; Nystagmus, pendular; Nystagmus, rotary; Paralysis; Paraparesis in Elderly; Pathophysiology/Rubral tremor; Position sense decreased/proprioception; Position sense decreased/proprioception Legs; Pyramidal tract signs; Saccard induced nystagmus/squint/latent ophthalmoplegia; Scanning speech; Segmental hypesthesia; Segmental/areflexia upper extremity; Sensory Ataxia; Sensory defects/lower extremities; Sensory loss/lower body/cord level; Slow speech; Slurred speech; Slurred speech/Chronic; Spastic paralysis/signs; Spasticity/Spastic gait; Speech Locution Problems; Spinal cord level lesion/signs; Staggering Gait; Steppage gait; Stroke syndrome/signs; Sudden unconsciousness; Transient limb paralysis/palsy; Tremor; Tremor in Elderly; Tremor,coarse; Uhthoff phenomenon Heat-trigger Weakness; Unable to tandem walk/straight line; Unable to walk; Unusual patterns/sensory loss; Vertical nystagmus; Vertigo; Vibratory sense decreased; Vibratory sense decreased Legs; Weak lower extremities; Weakness/Diffuse motor loss; Anorgasmia/Orgasm Dysfunction; Anorgasmic Female; Vaginal hypesthesia or anhedonism; Affect gay/happy inappropriate; Depressed/discouraged/sad; Destructive Behavior; Dysphoria; Emotional/affective lability; Euphoria/Elated/'high' behavior/Gaiety; Hallucination/visual; Psychiatric manifestations/problems/difficulties; Acute Back Pain; Back Pain; Backache; Chronic Back Pain; Limp; Non-localized shoulder area pain; Anosmia/Loss of sense of smell; Decreased sense of smell; Difficulty Talking; Voice Alteration; Voice Alteration in Elderly; Voice change/disturbance/Unusual; Overflow incontinence; Urinary Incontinence in Elderly; Urine Incontinence; Urine Retention Signs; Balance problems; Chronic Fatigue; Chronically ill patient/signs; Enervated/extreme acute fatigue; Episodic symptoms/events; Falling; Fatigue; Fatigue Tiredness Exhaustion; Heat intolerance/Warm all the time; Walking difficulties; Weakness; Weakness non-neuromuscular/systemic; Acute Vision Loss; Amaurosis fugats/transient blindness-vision loss; Anisocoria; Bilateral Vision Loss; Blindness/sudden/unilateral; Blindness/unilateral; Blurred Cloudy Vision; Central Vision Loss/Scotoma; Chronic Progressive Vision Loss; Chronic Vision Loss, Persistent; Color blindness acquired/dimming; Color vision dimmimg, monocular; Decreasing visual acuity; Difficulty Focusing Eyes; Dimming vision/acute; Diplopia Double vision; Double Image Vision Confirmed; Eye pain on eye movement; Eye symptoms/signs; Eyelid Retraction; Flashing Spots/Lights in Vision; Fleeting Blindness; Iridoplegia/spared accomodation reflex; Loss vision one eye, sudden; Marcus-Gunn pupil reaction/consensory sign; Movement phosphenes/flashes/scotomata/on eye motion; Opsoclonus/chaotic eye movements; Painless Vision Loss; Pallor/white optic disk; Positive scotomata/flashes; Ptosis, unilateral (blepharoptosis); Squint/sign; Temporary blindness; Transient Blindness One Eye; Unequal pupils; Upward gaze paralysis/voluntary; Visual Problems; Visual symptoms; Sound distortion; Sudden deafness; True Vertigo Sign Confirmed; Unilateral sudden deafness; Vertigo in Elderly
Clinical Presentation & Variations: Presentation/Ataxia in a Child Acute; Presentation/Movement Disorder Ataxia Dementia Progressive; Presentation/Back pain Hyperreflexia Incontinence
Disease Progression: Course/Episodic clusters of attacks; Course/Exacerbation/remission; Course/Relapsing; Course/Some residual effects/possible

Demographics & Risk Factors
Travel, Geographic & Climate Related Factors: Residence/travel/Northern Latitudes USA; Residence/travel/Temperate zone
Ethnic or Racial Factors: European racial stock/population
Established Disease Population: Patient/Multiple sclerosis; Patient/Postpartum status
Occupational Factors: Occupation/Health care worker; Occupation/Nurse
Family History: Family history/Multiple sclerosis
Sex & Age Groups: Population/Adult Aged Only; Population/Thirties adult

Laboratory Tests
Abnormal Lab Findings (Non Measured): CSF abnormal; CSF Colloidal gold curve abnormal; CSF Immunoelectrophoresis abnormal; CSF Protein increased/cells absent; HLA B27 (Lab); HLA B7 (Lab); HLA DR2 (Lab); HLA DRw2 (Lab); HLA DW2 (Lab)
Abnormal Lab Findings - Decreased: Complement (total CH50) level (Lab); Lactic acid/Lactate (Lab); Lipase (Lab); Lymphocytes (Lab); Phospholipids, serum (Lab); Uric acid, serum (Lab); CSF Complement
Abnormal Lab Findings - Increased: Anti-Smooth muscle (actin) antibodies (Lab); Isocitric dehydrogenase (Lab); LAP/Leucine Amino Peptidase (Lab); Pyruvate, plasma (Lab); Trypsin (Lab); CSF IGA; CSF IGG; CSF IGG index; CSF IGG synthesis rate; CSF IGM; CSF Immunoglobulin; CSF LDH; CSF Monocytes; CSF Myelin basic protein; CSF Oligoclonal banding immunoelectroelectrophoresis; CSF/Beta 2 Microglobulin

Diagnostic Test Results
Other Tests & Procedures: Lumbar puncture/abnormal; OCT/Optical Coherance Tomography Thin Retina; Visual Fields Test Abnormal; Visual fields/Central scotomata; Visual Fields/Central visual field loss; TEST/Caloric/nystagmus/challenge abnormal
Pathology: PATH/Brain abnormal; PATH/Brain corpus callosum lesion/defect; PATH/Brain Focal Degeneration/Lesion; PATH/Brain white matter multifocal lesions; PATH/Brain White matter plaque astrogliosis; PATH/Brain/Leptomeningeal Lesions; PATH/Brain/White matter/deficient myelin; PATH/Cerebral demyelination/biopsy/path; PATH/Gliosis spinal cord; PATH/Perivenular/focal demyelination/reactive gliosis
Electrodiagnosis: EEG/ABR/Auditory evoked response/potential abnormal/AEP; EEG/Evoked Potential Responses Abnormal; EEG/Somatic sensory evoked response/SSEP/SSER abnormal; EEG/Visual evoked response/abnormality; Electronystagmography Abnormal; TEST/Auditory brainstem response/abnormal/ABS response
CT Scan: CT Scan/Head Brain/Corpus callosum hypoplasia/agenesis; MRI/Head Brain Abnormal; MRI/Head corpus callosum/underside lesion; MRI/Head Deep white matter/multiple lesions; MRI/Head Demyelination white matter; MRI/Head multifocal low density lesions/white matter; MRI/Head Ovoid demyelination lesions; MRI/Head periventricular white matter lesions; MRI/Head Posterior fossa white matter lesions; MRI/Head Scan Abnormal; MRI/Head T2 and fluid -attenuated inversion recovery; MRI/Head White matter lesions 6mm/larger
X-RAY With contrast: UGI/Esophagus motility disorder; UGI/Hypopharynx/pooled barium vallecula

Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs: Amyotrophic lateral sclerosis; Anxiety disorder/panic attacks; Arnold-Chiari syndrome; Brain tumor; Chronic fatique syndrome (adult 'mono'); Eaton-Lambert syndrome; Encephalitis; Encephalitis, viral; Fibromyositis/fibromyalgia syndrome; Hypochondriasis; Inflammatory polyneuropathy/demyelinating/chronic; Meniere's disease; Meningitis, chronic; Myasthenia gravis; Primary Brain Neoplasm; Stiff-man syndrome; Syringomyelia
Associated Disease & Complications - Causes: Acute respiratory failure/Respiratory arrest; Anal Incontinence; Bells palsy/Facial nerve paralysis; Bladder, neurogenic uninhibited; Blindness, central; Brain stem lesion; Brown-Sequard syndrome; Cerebral sensory cortex lesion; CNS disease/involvement; Color blind; Constipation; Corpus callosum defect/agenesis; Deafness; Deafness, sensorineural; Dementia; Depression; Esotropia; Extrapyramidal disease/manifestation; Facial nerve palsy/secondary; Gastroparesis/atony; Hemiparesis; Hemiplegia; Hypouricemia; Impotence/Erectile dysfunction disorder; Internuclear ophthalmoplegia syndrome; Meningitis, chronic; Multiple sclerosis; Myelitis, transverse; Myelopathy manifestations/involvement; Neurobehavior Problems; Neurogenic bladder/cord; Obstipation; Optic neuritis; Organic brain syndrome; Paraparesis; Paraplegia; Paraplegia, spastic; Pneumonia, aspiration; Pseudobulbar palsy syndrome; Psychosis; REM Behavior disorder/RBD; Spinal cord lesion/dysfunction; Transverse myelitis, subacute; Trigeminal neuralgia; Urinary bladder retention; Vocal cord paralysis; Gastropathy Atonic; Ataxia Disorder; Demyelinating Disease; Facial Paralysis; Intracranial Lesion; Acute Urinary Retention; Oculogyric Crisis; Deafness Acquired
Disease Synergy: Synergy/Environmental extremes/temperature; Synergy/Fever; Synergy/General stress; Synergy/Heat stress; Synergy/Pregnancy

Disease Mechanism & Classification
Class: CLASS/Neurologic (category); CLASS/Spinal cord disorder (ex)
Pathophysiology: Pathophysiology/Cytokine gene polymorphism; Pathophysiology/Gene locus 1q31-q32; Pathophysiology/Gene locus Chromosome 1; Pathophysiology/Gene Locus Identified/OMIM database; Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations); Pathophysiology/Multisystem disease; Pathophysiology/Delayed gastric emptying/gastrostasis; Pathophysiology/Cerebral demyelination; Pathophysiology/CNS-Systemic Vertigo; Pathophysiology/Corpus callosum defect; Pathophysiology/Demyelination; Pathophysiology/Midbrain/mesencephalon lesion; Pathophysiology/Neurologic degenerative disorder (ex); Pathophysiology/Posterior columns cord def
Process: PROCESS/Allergy/collagen/autoimmune (category); PROCESS/Autoimmune disorder (ex); PROCESS/Great imitators/diseases (ex); PROCESS/Hereditary/Genetic predisposition (ex); PROCESS/Inflammatory/Allergy/immune (ex); PROCESS/Use/Age/atrophic disorder (category); PROCESS/CNS/White matter disorder (ex); PROCESS/Myelin involvement/disorder (ex)

Synonyms
Synonym: Synonym/Disseminated sclerosis; Synonym/MS

Treatment
Drug Therapy - Contraindication: RX/Adalimumab (Humira) injection; RX/Gamma interferon (Actimmune)
Drug Therapy - Indication: RX/Beta interferon; RX/Cladribine (Leustatin); RX/Corticosteroid (Cortisone); RX/Fingolimod (Gilenya); RX/Glatiramer (Copaxone); RX/IL-12/IL-23 Antagonist (Ustekinumab/Stelara); RX/Interferon B-1a (Avonex/Rebif); RX/Interferon B-1b; RX/Mitoxantrone (Novantrone); RX/Muscle relaxant medication; RX/Natalizumab (Tysabri); RX/Teriflumonide (Aubaglo); RX/Teriflunomide (Aubagio); RX/Vitamin D; SX/Stem cell transplant potential/future
Other Treatments: TX/Physical therapy; TX/Plasma exchange/FFP; TX/Plasmapheresis/exchange.

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