Clinical
Demographics
Lab
Diagnostic
Diseases
Classification
Synonyms
Treatment

Disease Comparison Results (show all mode) For:

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Rheumatoid arthritis

Found: 522 | Differences: 460

Hypothyroidism (myxedema)

Found: 521 | Differences: 459

Hypothyroidism (myxedema) and Rheumatoid arthritis sharing 56 common findings. ( show all, show common, show differences)

Clinical Manifestations
- Signs & Symptoms
  - Fever Non Infection
  - Nailfold capillary/giant loops sign
  - Tachycardia/Fast heart rate
  - Bruising/Ecchymosis
  - Dysplasia Toenails
  - Fair complexion/population/blond
  - Fever and Rash
  - Fingernails Telangiectasias
  - Hyperhidrosis/Chronic sweating excess
  - Leg Ulcers in Elderly
  - Leukonychia/white nails
  - Mottled legs
  - Non-tender nodules/subcutaneous
  - Rash
  - Red Hair/Freckled fair complexion
  - Skin fragile/thin/easily torn
  - Skin nodules/Subcutaneous nodules
  - Skin tears/easy abrasions signs
  - Splinter hemorrhage/nailbed
  - Subcutaneous nodules
  - Subcutaneous Nodules in Elderly
  - Subcutaneous nodules over bony prominences
  - Subcutaneous/mass
  - Excessive/easy bruising tendency
  - Anorexia Decreased appetite
  - Anorexia in Children
  - Dry mouth/Mucous membranes
  - Lymphadenopathy
  - Lymphadenopathy Systemic
  - Liver palms/erythema
  - Diffuse Aches and Pains
  - Finger Pain
  - Finger tightness/thickening/swelling
  - Fingers/spindle shaped
  - Hand edema/swelling
  - Hand Pain and Swelling Unilateral
  - Hand pain and swelling/unilateral
  - Hand Pains
  - Hand/Wrist Pain Unilateral
  - Hand/wrists induration/pain/edema
  - Hip Inner Thigh Pain
  - Muscle Pain
  - Muscle weakness
  - Myalgias
  - Puffy wrists
  - Stiffness
  - Stiffness in Extremities
  - Telangiectasia Nailbeds
  - Tender or painful muscles/Myalgias
  - Weak hand grip
  - Cervical radiculopathy syndrome
  - Grip strength decreased
  - Motor and sensory neuropathy/Polyneuropathy signs
  - Muscle stiffness/improves with exercise
  - Pleuritic chest pain
  - Depressed/discouraged/sad
  - Acute Back Pain
  - Ankle arthritis signs/symptoms
  - Ankle Pain
  - Arthralgias Polyarthralgias
  - Arthritis and Heart murmur
  - Arthritis and weight loss
  - Arthritis in Children
  - Arthritis with Abdominal Pain
  - Arthritis with Muscle Weakness
  - Arthritis with rash/dermatitis
  - Asymmetric Oligoarthropathy
  - Back Pain
  - Back Pain on Percussion/Spine
  - Back/Spine/Axial Pain
  - Backache
  - Bilateral knee effusions
  - Bilateral knee pains
  - Bone/Joint pains worse in morning
  - Chronic Back Pain
  - Crippling arthritis end-stage/signs
  - Elbow Pain
  - Enlarged/deformed joints
  - Fingers stiff/limited motion
  - Foot arthritis
  - Foot arthritis, bilateral
  - Foot Pain
  - Hand deformities of Rheumatoid arthr
  - Hand pain and swelling bilateral
  - Hand/Fingers arthritis
  - Heel pain/children
  - Hip Pain
  - Hip Pain In a Child
  - Hot Joint
  - Joint deformities
  - Joint effusion
  - Joint exam/signs
  - Joint inflammation signs
  - Joint Pains
  - Joint pains Arthralgias in Elderly
  - Joint redness/warmth
  - Joint Swelling
  - Joint/limit range of motion
  - Knee arthritis, acute, unilateral
  - Knee effusion, large, unilateral
  - Knee effusion/Fluid on knee
  - Knee Pain
  - Knee Swelling
  - Limp
  - Limping gait/orthopedic/antalgic
  - Limping in Adolescent
  - Low Back Pain
  - Metacarpophalangeal arthritis/signs
  - Metatarsophalangeal arthritis/signs
  - Midfoot pain
  - Monoarticular Arthritis in Elderly
  - Monoarticular Arthritis/One joint acute
  - Morning gel stiffness
  - Multiple Joint Arthritis
  - Neck and Arm Pain
  - Neck/Shoulder pain/stiffness
  - Oligoarthritis syndrome/signs
  - Palmar chieropathy/prayer sign
  - Palpable doughy thickened synovium/sign
  - Polyarticular Joint Pain
  - Popliteal mass/swelling
  - Proximal Interphalangeal joints involved Arthritis signs
  - Relapsing acute arthritis/signs
  - Severe/'angry' looking joint inflammation
  - Shoulder pain
  - Single Joint Pain
  - Skeletal problems/symptoms/signs
  - Slow onset arthritis
  - Stiffness of joints
  - Stiffness/joints brief inactivity
  - Symmetrical arthritis (signs)
  - Ulnar deviation metacarpal/wrist joints/sign
  - Warm Joint
  - Wrist arthritis/signs
  - Wrist pain
  - Wrist Pain and Swelling/Bilateral
  - Splenomegaly
  - Chronic Fatigue
  - Chronically ill patient/signs
  - Constitutional symptoms
  - Difficulty rising from chair
  - Enervated/extreme acute fatigue
  - Fatigue
  - Fatigue Tiredness Exhaustion
  - Fatigue Tiredness in Elderly
  - Fever
  - Fever and Normal Sed Rate
  - Fever Febrile Possible
  - Fever in elderly
  - Fever of unknown origin/chronic fever
  - Fever one week/non-infectious
  - Flu-Like Syndrome
  - Good days/Bad days/'Blahs' feelings
  - High body temperature
  - Malaise
  - Mucous membrane pallor
  - Multisystem disease/signs
  - Pallor
  - Pulchritude/Beautiful woman/Searls sign
  - Total body pain/truncal/extremities
  - Weakness
  - Weight loss
  - Blue eyed patient/sign
  - Blue sclera sign
  - Conjunctival pallor
- Typical Clinical Presentation
  - Arthritis with Subcutaneous/Skin Nodules
- Clinical Presentation & Variations
  - Presentation/Arteriosclerosis Young Age
  - Presentation/Recurrent pneumonia Child
  - Arthritis With Eye Signs
  - presentation/Acute polyarthritis syndrome Days
  - Presentation/Fever Arthritis signs
  - Presentation/Single Joint Arthritis
  - Fever and High Sed Rate
- Disease Progression
  - Course/Chronic disorder
  - Course/Chronic only
  - Onset/gradual
Demographics & Risk Factors
- Ethnic or Racial Factors
  - American Indian population
  - Irish/Scotch population
- Established Disease Population
  - Patient/Collagen disease
  - Patient/Chronic lymphocytic leukemia
  - Patient/Rheumatoid arthritis
- Population Group
  - Aged Adult
  - Woman
- Sex & Age Groups
  - Population/Adult ('twenties')
  - Population/Elderly Aged
  - Population/Female
  - Population/Seventies Adult
  - Population/Woman patient
Laboratory Tests
- Microbiology & Serology Findings
  - Serum specific antibodies increased
  - Microlab/Lyme disease (ELISA/IFA) titer
  - Microlab/Lyme disease Western Blot positive
  - Microlab/Joint fluid culture negative/sterile fluid
- Abnormal Lab Findings (Non Measured)
  - PLEURAL Exudate
  - Acute inflammatory markers elevated (Lab)
  - Anaphylatoxin C3a/des Arg present (Lab)
  - Immunelectrophoresis polyclonal globulin (Lab)
  - Normocytic anemia
  - Normocytic/Normochromic Anemia (Lab)
  - Right Shift (Viral) Differential Smear (Lab)
  - Very High Sed Rate
  - URINE Protein Electrophoresis (UPE) abnormal
  - URINE Sediment/Urinalysis abnormal
  - Class II HLA (Lab)
  - HLA B27 (Lab)
  - HLA DR1 (Lab)
  - HLA DR4 (Lab)
  - HLA DR4/DW14 (Lab)
  - HLA DR4/DW4 (Lab)
  - HLA RA/Epitope present (Lab)
  - HLA Specific association (Lab)
- Abnormal Lab Findings - Decreased
  - Cholesterol (Lab)
  - Complement (total CH50) level (Lab)
  - Ferritin, serum (Lab)
  - Glycoproteins (Lab)
  - Hematocrit (Lab)
  - Hemoglobin (Lab)
  - Iron, serum (Lab)
  - MCH (Lab)
  - MCHC (Lab)
  - MCV/Mean Corpuscular Volume (Lab)
  - Neutrophiles (Lab)
  - RBC/Red Blood Count (Lab)
  - Transferrin saturation (Lab)
  - Tyrosine (Lab)
  - URINE Pyridoxine
  - SYNOVIAL C3(Complement)
  - SYNOVIAL C4(Complement)
  - SYNOVIAL Complement
  - SYNOVIAL Glucose
  - PLEURAL Glucose
- Abnormal Lab Findings - Increased
  - Anti-CCP antibody (IGG anti-cyclic citrullinated peptide)
  - Anti-DNA antibody (double stranded) (Lab)
  - Anti-DNA-Histone (DNP) antibodies (Lab)
  - Anti-Filaggrin antibody
  - Anti-Histone antibody (Lab)
  - Anti-Kerasin antibodies (Lab)
  - Anti-neutrophilic/cytoplasm antibody (ANCA) (Lab)
  - Anti-RANA (RAP/RA nuclear antigen) antibody (Lab)
  - Anti-RNA antibody/Nrnp (Lab)
  - Anti-ssDNA (single stranded) antibody (Lab)
  - Antithyroid microsomal antibodies (Lab)
  - Anti-thyroid peroxidase (TPO) antibody (Lab)
  - ASCA Positive (Antibodies yeast S Cerevisiae) (Lab)
  - Circulating Total T-Cell Count
  - Alpha-2 globulin level (Lab)
  - ANA, peripheral/serum (Lab)
  - ANA/Antinuclear antibody/Fluorescent ANA (Lab)
  - Anti-DNA Antibody
  - Anti-Nuclear Antibody (ANA)
  - Anti-Sjogren ANA (Ro/La/SS-C)
  - Beta globulin, serum (Lab)
  - C3, serum (Lab)
  - CA-19-9 Pancreatic Ca/Glycoprotein antigen (Lab)
  - CD4 Helper cells (Lab)
  - Ceruloplasmin (Lab)
  - Cold agglutinins, serum (Lab)
  - Complement (total CH50) level (Lab)
  - Copper, serum (Lab)
  - C-reactive protein (Lab)
  - Creatine, serum (Lab)
  - Cryoglobulins (Lab)
  - Eosinophiles (Lab)
  - Ferritin, serum (Lab)
  - Fibrinogen, plasma (Lab)
  - Gamma globulin (Lab)
  - Globulin, serum (Lab)
  - Haptoglobin, serum (Lab)
  - Highly sensitive CRP (LAB)
  - IGD/Immunoglobulin D (Lab)
  - IGG/Immunoglobulin G (Lab)
  - IGM/Immunoglobulin M (Lab)
  - Immune complex titer (Raji) (Lab)
  - Interleukin-6/IL-6 levels (Lab)
  - LE Prep/Lupus erythematosis cell prep (Lab)
  - Monocytes (Lab)
  - Monocytosis
  - Neutrophiles (Lab)
  - Plasma cells, blood (Lab)
  - Platelet count (Lab)
  - Rheumatoid factor (Lab)
  - Sed Rate/ESR/Sedimentation rate (Lab)
  - Serum Amyloid A (SSA)
  - Sjogren ANA Antibodies (Ro/La/SS-C)
  - Total Protein, serum (Lab)
  - URINE Bence Jones protein
  - URINE Glutamic acid
  - URINE Glycine
  - SYNOVIAL Anti-CCP antibody
  - SYNOVIAL Anti-Filaggrin antibodies
  - SYNOVIAL Antinuclear antibodies
  - SYNOVIAL C3(Complement)
  - SYNOVIAL Complement
  - SYNOVIAL Neutrophiles
  - SYNOVIAL Rheumatoid factor
  - SALIVA IgA
Diagnostic Test Results
- Other Tests & Procedures
  - Skin test anergy
  - Arthrocentesis/abnormal
  - Athrocentesis/Joint tap/Abnormality
- Pathology
  - Bone Marrow/Iron stores/increased
  - BX/Gastric biopsy/Gastric hemorrhagic vasculitis
  - BX/Synovial abnormal
  - PATH/Cartilage biopsy/Abnormal
  - PATH/Granulomatous tissue/specimen
  - PATH/Proliferation plasma cells/lymphocytes
- CT Scan
  - CT/Dexa-Scan Bone density Abnormal
- X-RAY
  - Xray/Calcified bursa/tendon
  - Xray/Muscle calcification
  - Xray/Soft tissue calcification/muscle/subcutaneous
  - Xray/Calcaneal plantar bone resorption
  - Xray/Calcified symphysis pubis
  - Xray/Distal Clavicle Bone Resorption/Chest
  - Xray/Hands abnormal
  - Xray/Heel periostitis/achilles tendonitis
  - Xray/Heel spur/fluffy pattern
  - Xray/Joint abnormal
  - Xray/Joint space narrowing/Joint
  - Xray/Joint/cartilage erosion signs
  - Xray/Metacarpal Phalangeal Joint Erosion
  - Xray/Odontoid erosion/Neck
  - Xray/Periarticular erosion/arthritis
  - Xray/Periarticular knee calcifications
  - Xray/Periarticular osteopenia/Joint
  - Xray/Periarticular soft tissue swelling/Joint
  - Xray/Ribs inferior bone resorption
  - Xray/Ribs, notching margins
  - Xray/Sacroiliac joint Widened
  - Xray/Subchondral cysts/Joint
  - Xray/Ulna Styloid Erosion
  - Xray/Wrist Joint Erosions
  - Xray/Intraorbital calcifications/Head
- Ultrasound
  - Echo/Pulmonary artery hypertension
- Angiography
  - Lymphangiogram/Abnormal
  - Arthrogram/knee many filling defects
Associated Diseases & Rule outs
- Associated Disease & Complications - Rule Outs
  - Adult Still's disease/RA presentation
  - Arthritis Pyogenic Septic
  - Arthritis with occult infection
  - Charcot neuroarthropathic joint
  - Churg Strauss pulmonary vasculitis
  - Fibromyositis/fibromyalgia syndrome
  - Hypertrophic osteoarthropathy
  - Intermittant hydrarthrosis/Hydrarthrosis
  - Lupus erythematosis, systemic
  - Osteoarthritis, degenerative
  - Osteoarticular Sporotrichosis
  - Palindromic rheumatism
  - Polyarthritis, infectious
  - Polymyalgia rheumatica
  - Pseudogout (CPPD) arthritis
  - Psoriatic arthritis
  - Reiter's syndrome
  - Rheumatic fever
  - Spondyloarthropathy, undifferentiated
- Associated Disease & Complications - Causes
  - Adult Still's disease/RA presentation
  - Amyloidosis, hepatosplenic
  - Amyloidosis, renal
  - Amyloidosis, secondary
  - Amyloidosis, systemic
  - Anemia
  - Anemia of chronic disease
  - Anergic status
  - Aortic regurgitation
  - Arteriosclerosis
  - Arteriosclerotic heart disease
  - Arthritis
  - Arthritis Axial Skeleton
  - Arthritis Pyogenic Septic
  - Aseptic necrosis humeral head/epiphysis
  - Atlanto/axial injury
  - Atlanto/odontoid arthritis
  - Atlanto/odontoid dislocation/fracture
  - AV node lesion/infiltrate
  - Avascular necrosis bone/process
  - Bacterial polyarticular arthritis
  - Bronchocentric granulomatosis
  - Cardiomyopathy
  - Cardiomyopathy, secondary
  - Carpal tunnel syndrome
  - Chronic hives/urticaria
  - Circulating anticoagulants disorder (Lab)
  - Collagen disease
  - Collagen vascular disease
  - Constrictive pericarditis/chronic
  - Cutaneous vasculitis
  - Depression
  - DeQuervain's tendonitis/thumb
  - Dermatomyositis
  - Eosinophilia Hypereosinophilia
  - Erythema multiforme
  - Felty's syndrome
  - Gastrointestinal amyloidosis
  - Hemolytic Anemia
  - Hemolytic anemia/autoimmune
  - Hyperglobulinemia
  - Hypersplenism
  - Iatrogenic corticosteroid/treatment/effects
  - Inflammatory myopathy
  - Intestinal/gut lymphoma
  - Kidney stone/Nephrolithiasis/Urolithiasis
  - Leukocytoclastic angiitis
  - Listeria meningitis
  - Livedo reticularis
  - Male osteoporosis syndrome
  - Mitral regurgitation
  - Mononeuritis, multiplex
  - Multi-radicular Polyneuropathy syndrome
  - Myasthenia gravis
  - Nail dystrophy
  - Neuropathy
  - Osteoarthritis, degenerative
  - Osteoporosis/osteopenia
  - Palindromic rheumatism
  - Pathologic fractures
  - Peptic ulcer disease
  - Pericardial effusion
  - Pericarditis, acute
  - Peripheral neuropathy
  - Plantar fasciitis
  - Pleural Effusion
  - Pleurisy
  - Pneumocystis Jiroveci/Carinii Pneumonia (PCP)
  - Pneumonia, recurrent
  - Pneumonia/Bronchopneumonia
  - Polyarteritis nodosa
  - Polyarthritis in Children
  - PolyArthritis in Elderly
  - Polyarthritis syndrome/Multiple joints/weeks
  - Polychondritis, relapsing
  - Polymyositis
  - Polyneuritis
  - Pulmonary hypertension
  - Pulmonary Interstitial fibrosis, secondary
  - Raynaud's syndrome
  - Renal tubule acidosis, acquired
  - Renal vasculitis
  - Rheumatoid arthritis
  - Rheumatoid lung disease
  - Rheumatoid nodule
  - Scleritis/Episcleritis
  - Scleromalacia
  - Seronegative arthritis
  - Sideroblastic Anemia Sideroachrestic
  - Sjogren's sicca syndrome
  - Superior mesenteric artery insufficiency, acute
  - Synovitis/arthritis
  - Tenosynovitis
  - Thoracic aneurysm/dilated aorta/ectasia
  - Thoracic Aortic Aneurysm
  - Thrombocytosis
  - Urticaria/hives
  - Vasculitis syndrome
  - Xerostomia
  - Leg ulcers
  - Anemia in Elderly
  - Hypergastrinemia
  - Polyneuropathy
  - Metabolic Bone Disease
  - Monoarthritis Acute
  - PolyArthritis
- Disease Synergy
  - Synergy/General stress
Disease Mechanism & Classification
- Class
  - CLASS/Atlanto/odontoid involvement/disorder (ex)
  - CLASS/Axial skeletal involvement/disorder (ex)
  - CLASS/Joint disorder (ex).
  - CLASS/Knee disorder (ex)
  - CLASS/Shoulder involvement/disorder (ex)
  - CLASS/Skeletal (category)
  - CLASS/Multisystem/organ involvement/pathology (ex)
  - CLASS/Systemic/no comment (category)
- Pathophysiology
  - Pathophysiology/Cytokine gene polymorphism
  - Pathophysiology/Gene locus Chromosome 6
  - Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
  - Pathophysiology/Molecular microbe mimocry/share epitope
  - Pathophysiology/Hypersensitivity Vasculitis
  - Pathophysiology/CD4/T-cell synovitis
  - Pathophysiology/Osteoporosis Secondary
  - Pathophysiology/Seronegative polyarthritis
  - Pathophysiology/Synovial activated macrophage
  - Pathophysiology/Shared epitope [HLA DRWB1 04140-0412]
  - Pathophysiology/Tumor necrosis factor activation effect
  - Pathophysiology/Activated CD4/T-cell
  - Pathophysiology/Activated cellular immunopathology
  - Pathophysiology/Chemotaxis failure/phagocytes/effect
  - Pathophysiology/Immune physiology/defective
- Process
  - PROCESS/Allergy/collagen/autoimmune (category)
  - PROCESS/Ethnic predilection (ex)
  - PROCESS/Inflammatory/Chronic
  - PROCESS/Inflammatory/Granulomatous disease (ex)
  - PROCESS/Inflammatory/subacute
  - PROCESS/Granulomatous Disease
  - PROCESS/Systemic illness (ex)
Synonyms
- Synonym
  - Synonym/Overlap Connective Dis Variant
Treatment
- Drug Therapy
  - RX/Adalimumab (Humira) injection
  - RX/Anakinra (Kineret)
  - RX/Antidepressant medication
  - RX/Anti-inflammatory drug
  - RX/Anti-TNF drug
  - RX/Aspirin (Acetylsalicylic acid)
  - RX/Auranofin (Ridaura)
  - RX/Azathioprine (Imuran)
  - RX/Celecoxib (Celebrex)
  - RX/Certolizumab (Cimzia)
  - RX/Chloroquin (Aralen)
  - RX/Diclofenac (Voltaren)
  - RX/Etanercept (Enbrel)/Anti-TNF
  - RX/Gold
  - RX/Golimumab (Simponi)
  - RX/Hydroxychloraquin (Plaquenil)
  - RX/Immune-suppression
  - RX/Indomethacin (Indocin)
  - RX/Infliximab (Remicade)
  - RX/Intra-articular cortisone
  - RX/Methotrexate (Amethopterin)
  - RX/Multivitamin supplements
  - RX/Penicillamine (Cupramine)
  - RX/Prednisone (Deltasone)
  - RX/Rituximab (Rituxan)
  - RX/Salicylate/aspirin
  - RX/Sulfasalazine(Azulfadine)
  - RX/Tocilizumab (Actemra)
  - RX/Tramadol (Ultram)
  - SX/Stem cell transplant potential/future
- Other Treatments
  - TX/Cytapheresis/technique
  - TX/Physical therapy

Clinical Manifestations
- Signs & Symptoms
  - Edema in Children
  - Particular physiognomy/Odd looking kids
  - Swelling/Puffy
  - Craniofacial Abnormalities/Congenital
  - Edema face/lip
  - Facial edema/swelling
  - Facial expression dull/Dull facies
  - Facial/nose deformity/acquired
  - Facies particular
  - Heavy facial features
  - Breast Discharge
  - Breast Swelling Bilateral
  - Galactorrhea/Male
  - Lactorrhea in a male
  - Lactorrhea/Galactorrhea/Prolonged lactation
  - Apical impulse absent
  - Bilateral ankle swelling
  - Bilateral leg edema/swelling
  - Cardiomegaly/Heart dilatation
  - Chronic hypotension
  - Clubbing of fingers/toes
  - Clubbing/fingers
  - Diastolic hypertension
  - High blood pressure child
  - High blood pressure/sign
  - Hypotension with Relative Bradycardia
  - Pulse pressure decreased/narrow/Parvus pulse
  - Quiet heart/soft sounds/distant
  - Slow pulse/Bradycardia
  - Alopecia/patchy eyebrows
  - Baldness/Alopecia
  - Coarsening hair
  - Coarsening skin
  - Decreased sweating/Absent sweating
  - Dry brittle hair/Lank lifeless hair
  - Dry skin/scaling dry skin
  - Fingernails brittle/thinner/splitting
  - Hair coarse/stiff
  - Hair loss
  - Hirsutism
  - Hypertrichosis
  - Loss of body hair/thinning
  - Nails hypoplastic/dysplastic
  - Nails pitting
  - Non-scarring Alopecia/balding
  - Pruritis Itching
  - Scalp hair sparse/thin
  - Skin cold/diffuse
  - Spoon nails/soft/translucent
  - Thickened skin/diffuse
  - Yellow skin discoloration
  - Delayed adolescence/secondary sex changes
  - Delayed female adolescence
  - Delayed Puberty
  - Enlarged thyroid gland
  - Enlarged Thyroid Gland in Children
  - Enlarged Thyroid Gland in Elderly
  - Small/absent thyroid gland/sign
  - Stunted growth
  - Thyroid induration
  - Thyromegaly/Symmetric enlargement
  - Anorgasmic male
  - Loss of libido,male
  - Sexual dysfunction
  - Anemia symptoms/chronic
  - Anorexia Decreased appetite
  - Anorexia in Infant
  - Bowel habit change
  - Constipation in Children
  - Constipation in Elderly
  - Failure to Thrive
  - Failure to Thrive Child
  - Failure to thrive/infant sign
  - Fasting intolerant
  - Fecal Soiling in a Child
  - Poor weight gain/child
  - Weight gain in Children
  - Weight gain in Elderly
  - Altered taste/Taste perception
  - Decreased taste ability/Hypoguesia
  - Large tongue/macroglossia
  - Oral mucosa/lacks turgor
  - Clinical jaundice/Yellow skin and eyes
  - Yellow eyeballs/Scleral icterus
  - Yellow skin/white sclera
  - Cold hands/fingers and toes
  - Cramping in Extremities
  - Diffuse Aches and Pains
  - Edema of Lower Extremities
  - Hand edema/swelling
  - Hypotonia
  - Muscle cramps/spasms
  - Muscle Pain
  - Muscle weakness
  - Myalgias
  - Proximal muscle weakness
  - Swelling of hands and feet
  - Tender or painful muscles/Myalgias
  - Weak/Weak as a kitten (symptom)
  - Absent knee reflexes
  - Altered mental status Mental status change
  - Ankle reflexes decreased
  - Apathy/Indifference
  - Ataxia
  - Ataxia
  - Behavior problems
  - Cognitive defect
  - Cognitive deficit/mild
  - Confusion/Disoriented
  - Delirium
  - Delirium/Agitated delirium
  - Difficulty concentrating/Distraction/Forgetful
  - Drowsiness/somnolence
  - Headache
  - Hung reflexes (prolonged relaxation)/Woltman sign
  - Hyporeflexia/DTRs decreased
  - Impaired judgement/signs
  - Insomnia
  - Large anterior fontanel
  - Lethargy/torpor
  - Loss of Taste
  - Memory Loss in Elderly
  - Mental Slowing Deteriation
  - Motor slowing
  - Near recall/memory deficit/defect
  - Paresthesias
  - Sleep attacks/extreme daytime drowsiness
  - Spasms in Both Legs
  - Staggering Gait
  - Stupor/poor reponse to stimulus
  - Sudden unconsciousness
  - Symmetric Polyneuropathy
  - Unconscious/Narcosis status
  - Weak reflexes
  - Weakness/Diffuse motor loss
  - Amenorrhea
  - Amenorrhea, primary
  - Amenorrhea, secondary
  - Anorgasmia/Orgasm Dysfunction
  - Anorgasmic Female
  - Breakthrough bleeding/Metorrhagia
  - Delayed menarche
  - Flooding menstrual bleeding
  - Irregular periods/vaginal bleeding
  - Loss of libido,women
  - Metamenorrhagia
  - Uterine Bleeding
  - Vaginal Bleeding
  - Depressed/discouraged/sad
  - Psychiatric manifestations/problems/difficulties
  - Psychomotor retardation
  - Psychotic behavior/symptomatic
  - Arthralgias Polyarthralgias
  - Joint effusion
  - Joint Pains
  - Joint pains Arthralgias in Elderly
  - Joint Swelling
  - Anosmia/Loss of sense of smell
  - Decreased sense of smell
  - Hoarseness
  - Nose blocked/stuffy
  - Odd sounding voice/husky
  - Runny nose/rhinorrhea
  - Snoring
  - Voice Alteration
  - Voice Alteration in Elderly
  - Voice change/disturbance/Unusual
  - Chronic Fatigue
  - Chronic Low Body Temperature
  - Cold intolerance
  - Enervated/extreme acute fatigue
  - Episodic symptoms/events
  - Fatigue
  - Fatigue Tiredness Exhaustion
  - Fatigue Tiredness in Children
  - Fatigue Tiredness in Elderly
  - Growth/development delay
  - Hypersomnia/Increased need for sleep
  - Listlessness/lassitude
  - Low body temperature
  - Pallor
  - Short stature
  - Short stature Child
  - Spells/Episodes of weakness
  - Spousal/family concern/complaint
  - Total body pain/truncal/extremities
  - Weakness
  - Weakness non-neuromuscular/systemic
  - Weakness, Gradual Onset
  - Weight gain
  - Weight loss
  - Bilateral Eyelid Edema
  - Eye brow lesions
  - Eyebrow loss, outer third
  - Loss eye brows
  - Night blindness/Impaired night vision
  - Periorbital edema/Puffy eyes
  - Acute Hearing Loss
  - Hearing loss
  - Mixed Sensory/Conductive deafness
  - Tinnitus
- Clinical Presentation & Variations
  - Presentation/Elderly Unusual Patterns
  - Presentation/Multiple deformities newborn (odd look)
  - Presentation/Warfarin Insensitivity Tolerance
  - Presentation/Large Pericardial Effusion
  - Presentation/Diabetic Decreased need for Insulin
  - Presentation/Increasing insulin sensitivity Diabetic
  - Anemia with Low Reticulocyte Count
- Disease Progression
  - Onset/insidious
  - Galactorrhea
  - Heart Failure in Pregnancy
Demographics & Risk Factors
- Past History
  - Past history/Thyroidectomy
  - Past history/Thyrotoxicosis
- Established Disease Population
  - Patient/Down's syndrome
  - Patient/Autoimmune polyglandular disease
  - Patient/Goiter
  - Patient/Hashimoto's thyroiditis
  - Patient/Hypothyroidism (myxedema)
  - Patient/Thyroidectomy
  - Patient/Pernicious anemia
- Population Group
  - Aged Adult
  - Middle Age Adult
  - Woman
- Family History
  - Family history/Goiter
  - Family history/Thyroid disease
- Event, Activity, Behavioral & Seasonal Factors
  - Event/Springtime
- Sex & Age Groups
  - Population/Adult ('twenties')
  - Population/Adult Aged Only
  - Population/Adult/all
  - Population/Elderly Aged
  - Population/Female
  - Population/Fifties adult
  - Population/Middle-aged adult
  - Population/Seventies Adult
  - Population/Woman patient
Laboratory Tests
- Microbiology & Serology Findings
  - Reticulocytosis
- Abnormal Lab Findings (Non Measured)
  - Fasting hypoglycemia (Lab)
  - Hepatic Enzymes Abnormal (Lab)
  - Hyperprolactinemia
  - Liver Functions Abnormal (Lab)
  - Macrocytic anemia (Lab)
  - Macrocytosis/smear (Lab)
  - Normocytic anemia
  - Normocytic anemia/low retic count
  - Normocytic/Normochromic Anemia (Lab)
  - Postprandial Glucose Increased
  - Serum lipids increased (Lab)
  - Transaminase elevation (Lab)
  - Normal Urinalysis
  - CSF Protein increased/cells absent
  - SAAG Serum-ascitic albumin grad/Low (Lab)
- Abnormal Lab Findings - Decreased
  - Alkaline phosphatase, serum (Lab)
  - Factor 8 (Lab)
  - Factor IX/PTC (Lab)
  - Ferritin, serum (Lab)
  - Folic acid/Folate (Lab)
  - Free T4 (Lab)
  - FTI/Free Thyroxin Index (Lab)
  - Gastrin, serum (Lab)
  - Glucose, blood (Lab)
  - Hematocrit (Lab)
  - Hemoglobin (Lab)
  - Iron, serum (Lab)
  - MCH (Lab)
  - Osmolality, serum (Lab)
  - RBC/Red Blood Count (Lab)
  - Reticulocytes (Lab)
  - Sodium, serum (Lab)
  - T3 (RIA) serum level (Lab)
  - Thyroid Binding Globulin (Lab)
  - Thyroxin/T4 (Lab)
  - Transferrin saturation (Lab)
  - Tri-iodothyronine/T3 as Resin Uptake (Lab)
  - Tyrosine (Lab)
  - Vitamin B12, serum (Lab)
  - URINE 17-Hydroxycorticosteroids
  - URINE 17-Ketosteroids
  - URINE Calcium
  - URINE Hydroxyproline
  - URINE Magnesium
- Abnormal Lab Findings - Increased
  - Anti-parietal cell antibody (Lab)
  - Antithyroglobulin antibodies (Lab)
  - Antithyroid antibodies (Lab)
  - Antithyroid microsomal antibodies (Lab)
  - Anti-thyroid peroxidase (TPO) antibody (Lab)
  - ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)
  - ALT/SGPT (Alanine transferase) (Lab)
  - Aspartamine aminotransferase (SGOT, AST) (Lab)
  - AST/SGOT (aspartamine transferase) (Lab)
  - Basophiles (Lab)
  - Bilirubin, serum (Lab)
  - Carotene/Vitamin A level (Lab)
  - Cholesterol (Lab)
  - CK-MM (Lab)
  - CPK/CK/Creatine kinase/Creatine phosphokinase (Lab)
  - Direct bilirubin (Lab)
  - Estrogen, serum (Lab)
  - HDL (High density lipoprotein) (Lab)
  - Homocysteine serum (Lab)
  - LDH/Lactic Dehydrogenase (Lab)
  - LDL (Low density lipoprotein) (Lab)
  - Magnesium (Lab)
  - MCV/Mean Corpuscular Volume (Lab)
  - Norepinephrine, plasma (Lab)
  - Phospholipids, serum (Lab)
  - Plasma Retinol
  - Plasma Retinol Binding Protein
  - Prolactin (Lab)
  - Testosterone Total (Lab)
  - Thyroid Binding Globulin (Lab)
  - TIBC/Total Iron Binding capacity (Lab)
  - Triglycerides (Lab)
  - TSH/Thyroid stimulating hormone (Lab)
  - Uric acid, serum (Lab)
  - VLDL (very-low-density lipoprotein) (Lab)
  - URINE Creatinine
  - URINE Myoglobin
  - URINE Protein (Albumin)
  - URINE Sodium
  - CSF Protein
Diagnostic Test Results
- Other Tests & Procedures
  - TEST/Sweat test abnormal
  - TEST/TRH/TSH response exaggerated
  - Lumbar puncture/Increased CSF pressure/LP test
  - TEST/Glucose intolerance/GTT abnormal
  - TEST/Glucose tolerance test/reactive hypoglycemia
- Pathology
  - Bone Marrow/Megaloblastic/Pathology
- Isotope Scan
  - Isotope/RAI Uptake low/thyroid scan (I 123)
  - Isotope/RAI uptake/quantitative high thyroid (I 123)
  - Isotope/Thyroid Scan Abnormal
  - Isotope/Schilling Test/B12 isotope/Abnormal
  - Isotope/Gastric Emptying Delay
- Electrodiagnosis
  - Electromyography/Abnormal findings(EMG)
- EKG (ECG)
  - EKG/Low voltage all leads (ECG)
  - EKG/Non-specific ST-T Wave changes (ECG)
  - EKG/Prolonged QT interval (ECG)
  - EKG/Persistent T Wave inversion (ECG)
  - EKG/Prominent U Waves (ECG)
  - EKG/T Wave inversion (ECG)
  - EKG/Sinus bradycardia (ECG)
  - EKG/Sinus pause (ECG)
  - EKG/Low voltage/chest leads (ECG)
  - EKG/Low voltage/limb leads (ECG)
- CT Scan
  - CT Scan/Head Enlarged pituitary gland
- X-RAY
  - Xray/Cardiomegaly/Chest
  - Xray/Chest abnormal
  - Heel pad thickened
  - Xray/Chest/Lung fields/Abnormal
  - Xray/Pleural fluid/Chest
  - Xray/Bullet shaped vertebral bodies/Spine
  - Xray/Delayed bone age/slow epiphysis closures
  - Xray/Delayed cranial ossification in a child/Head
  - Xray/Heel pad thickened
  - Xray/Symphysis Pubis Widened
- X-RAY With contrast
  - SBS/Delay/Slow intestinal transit
  - SBS/Intestine loops dilated/non-obstruct (Xray)
  - UGI/Esophagus motility disorder
  - UGI/Gastric Emptying Time Delay
  - UGI/Gastric retention
- Ultrasound
  - Echo/Pericardial fluid
Associated Diseases & Rule outs
- Associated Disease & Complications - Rule Outs
  - Alzheimers disease
  - Angioedema/angioneurotic edema
  - Chronic bowel pseudo-obstruction syndrome
  - Congestive heart failure
  - Depression
  - Dermatomyositis
  - Emphysema/COPD/Chronic lung disease
  - Encopresis/childhood
  - Fibromyositis/fibromyalgia syndrome
  - Hypercalcuria
  - Myositis, inclusion body
  - Narcolepsy
  - Obesity
  - Polymyositis
  - Prolactinoma, pituitary
  - Rhinitis, atopic
  - Right congestive heart failure
- Associated Disease & Complications - Causes
  - Abortion, habitual (spontaneous,recurrent)
  - Abortion/miscarriage
  - Acanthosis nigricans
  - Acidosis, respiratory
  - Alopecia areata
  - Alveolar hypoventilation/extrapulmonary
  - Anemia
  - Anhydrosis/Absent sweating/diffuse
  - Arteriosclerosis
  - Ascites
  - Ascites in Elderly
  - Basophilia
  - Brady-arrhythmia
  - Cardiomyopathy
  - Cardiomyopathy, dilated
  - Carotenemia
  - Carpal tunnel syndrome
  - Central respiratory drive depression
  - Cerebral thrombosis
  - Chronic bowel pseudo-obstruction syndrome
  - Chronic fatique syndrome (adult 'mono')
  - Chylomicronemia syndrome
  - Coma in Elderly
  - Coma/Unconscious
  - Congestive heart failure
  - Constipation
  - Cretinism/congenital hypothyroidism
  - Deafness
  - Dementia
  - Depression
  - Digitalis toxicity/poisoning
  - Dysfunctional Uterine Bleeding
  - Edema
  - Encephalopathy/CNS effect
  - Encopresis/childhood
  - Esophageal motility disorder
  - Folic acid deficiency anemia
  - Gastric retention/acute
  - Gastroparesis/atony
  - Glucose intolerance
  - Growth retardation/failure
  - Gynecomastia
  - Hallucinations
  - Hypercholesterolemia
  - Hyperlipidemia
  - Hypermagnesemia
  - Hypertension
  - Hypertriglyceridemia
  - Hyperuricemia
  - Hypoglycemia
  - Hypoglycemia, diabetic/treatment
  - Hyponatremia
  - Hypo-Osmolar State
  - Hypothermia
  - Hypothermia, accidental/exposure
  - Hypothyroid myopathy
  - Hypothyroidism (myxedema)
  - Hypoventilation, alveolar
  - Hypovitaminosis B12
  - Ichthyosis
  - Impotence/Erectile dysfunction disorder
  - Increased CNS pressure/Intracranial hypertension
  - Infertility/sterility male
  - Infertility/sterility, female
  - Intestine, psuedo-obstruction
  - Jaundice
  - Juvenile hypothyroidism
  - Lipodystrophy generalized
  - Menorrhagia
  - Metabolic encephalopathy
  - Microcephaly/oligophrenia
  - Myocardial infarction, acute
  - Myoglobinuria
  - Myopathy/secondary/nonspecific
  - Myxedema coma
  - Nasal obstruction
  - Neurobehavior Problems
  - Obesity
  - Obesity in Elderly
  - Obstipation
  - Obstructive sleep apnea/Children
  - Onycholysis
  - Ovarian Dysfunction
  - Pericardial effusion
  - Peripheral neuropathy
  - Peritoneal Effusion
  - Pleural Effusion
  - Polyneuritis
  - Precocious puberty/male
  - Proteinuria
  - Pruritis ani
  - Pseudodementia/Reversible dementia
  - Pseudogout (CPPD) arthritis
  - Psychosis
  - Raynaud's syndrome
  - Rhinitis, chronic hypertrophic
  - Rhinitis/secondary, non specific
  - Secondary Psychosis/Symptomatic
  - Sideroblastic Anemia Sideroachrestic
  - Sinus bradycardia
  - Sleep apnea/central type
  - Sleep apnea/obstructive type
  - Superior mesenteric artery insufficiency, acute
  - Tendonopathy
  - Testicular Failure
  - Thyroid acropachy
  - Type IV hyperlipidemia
  - Vertebrobasilar artery insufficiency
  - Vitamin B12 deficiency
  - Xeroderma
  - Anemia in Elderly
  - Gastropathy Atonic
  - Polyneuropathy
  - Anovulatory Cycles
  - Chronic Respiratory Acidosis
  - Continued Hypercapnea
  - Proteinuria in Elderly
- Disease Synergy
  - Synergy/Digitalis/digoxin toxicity
  - Synergy/Obesity
Disease Mechanism & Classification
- Class
  - CLASS/Endocrine gland (category)
  - CLASS/Thyroid gland disorder (ex)
- Pathophysiology
  - Pathophysiology/Hypometabolic state
  - Pathophysiology/Hypothermic
  - Pathophysiology/Insulin sensitive effect
  - Pathophysiology/Neurodevelopmental disorders
  - Pathophysiology/Negative inotropic effect
  - Pathophysiology/Enlarging pituitary gland
  - Pathophysiology/Hypogonadotrophic hypogonadism
  - Pathophysiology/TSH excess secretion
  - Pathophysiology/Secondary Testicular Failure
  - Pathophysiology/Sperm Production Decreased
  - Pathophysiology/Delayed gastric emptying/gastrostasis
  - Pathophysiology/Acquired Neuropathy
  - Pathophysiology/CNS Respiratory Drive Center Suppressed
  - Pathophysiology/CSF Pressure Increased
  - Pathophysiology/Chronic anovulation
  - Pathophysiology/Hypoestrogenic Anovulation
  - Pathophysiology/Ovarian dysfunction anovulation
  - Pathophysiology/Lung Hypoventilation
  - Pathophysiology/Lung Ventilation Mechanics
  - Pathophysiology/Metabolic rate Decreased
- Process
  - PROCESS/Endocrine/humoral disorders (category)
  - PROCESS/Vegetative-Autonomic/Endocrine (category)
  - PROCESS/Dystostosis/craniofacial (ex)
Treatment
- Drug Therapy
  - RX/Thyroxin/thyroid hormone (Synthroid/T4)

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