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Disease Comparison Results (show differences mode) for Hemochromatosis and Prolymphocytic leukemia

Clinical
Demographics
Lab
Diagnostic
Diseases
Classification
Synonyms
Treatment
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Prolymphocytic leukemia

Found: 61 | Differences: 40

Hemochromatosis

Found: 330 | Differences: 309

Hemochromatosis and Prolymphocytic leukemia sharing 21 common findings. (show all, show common, show differences)

Clinical Manifestations
Signs & Symptoms: Epistaxis Children; Massive splenomegaly; Fever; Fever Febrile Possible; Fever in elderly; Flu-Like Syndrome; High body temperature
Disease Progression: Course/Prognosis bad/usually; Pancytopenia with Hypercellular Marrow

Demographics & Risk Factors
Established Disease Population: Patient/Chronic lymphocytic leukemia
Population Group: Aged Adult
Sex & Age Groups: Population/Elderly Aged; Population/Seventies Adult

Laboratory Tests
Microbiology & Serology Findings: Stool Microscopic polys present
Abnormal Lab Findings (Non Measured): Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Decreased: Hematocrit (Lab); Hemoglobin (Lab); Platelet count (Lab); RBC/Red Blood Count (Lab)
Abnormal Lab Findings - Increased: WBC; Lymphocytes (Lab); Prolymphocytes (Lab); WBC/White Blood Cell Count/Leukocytes (Lab)

Diagnostic Test Results
Pathology: Bone marrow/Increased lymphocytes

Associated Diseases & Rule outs
Associated Disease & Complications: Anemia; Lymphocytosis; Mesenteric vein thrombosis; Prolymphocytic leukemia; Thrombocytopenia

Disease Mechanism & Classification
Class: CLASS/Hematologic (category); CLASS/Lymphocyte disorder (ex)
Process: PROCESS/Neoplastic (category); PROCESS/Blood dyscrasia/leukemic process (ex)

Synonyms
Synonym: Synonym/PLL

Treatment
Drug Therapy: RX/Alkylating agents; RX/Chemotherapy(cancer); RX/Fludarabine (Fludara); RX/Vincristine (Oncovin); SX/Stem cell transplant/autologous; SX/Stem-cell transplant

Clinical Manifestations
Signs & Symptoms: Breast Swelling Bilateral; Arrhythmia signs/irregular pulse; Cardiac Symptoms/Signs; Cardiomegaly/Heart dilatation; Chronic hypotension; Bronze Skin Color; Brown skin discoloration; Extensor surfaces/skin manifestations; Increased pigmentation/tanning/hyperpigmented; Koilonychia/Spoon nails; Loss of body hair/thinning; Slate gray pigmentations; Spider nevi/angiomata/Abdominal sign; Subcutaneous nodules; Yellow skin discoloration; Loss of libido,male; Sexual dysfunction; Small testes; Small/soft testes; Abdominal Pain; Jaundice/Yellow skin and eyes; Liver firm/edge indurated; Liver palms/erythema; Yellow eyeballs/Scleral icterus; Cramping in Extremities; Hand Pains; Muscle cramps/spasms; Muscle Pain; Myalgias; Pain in Extremities/Melalgias; Palmar Erythema/Redness; Tender or painful muscles/Myalgias; Apathy/Indifference; Hyperesthesia; Lethargy/torpor; Neurological symptoms/signs; Spasms in Both Legs; Amenorrhea; Amenorrhea, secondary; Loss of libido,women; Dyspnea on exertion; Arthralgias Polyarthralgias; Arthritis Children; Arthritis of major joint; Arthritis with Abdominal Pain; Asymmetric Oligoarthropathy; Joint exam/signs; Joint Pains; Joint pains Arthralgias in Children; Joint pains Arthralgias in Elderly; Large joint involvement/manifestation; Metacarpophalangeal arthritis/signs; Monoarticular Arthritis/One joint acute; Multiple Joint Arthritis; Oligoarthritis syndrome/signs; Polyarticular Joint Pain; Shoulder arthritis signs/symptoms; Symmetrical Osteoarthritis Bilateral metacarpal joints; Wrist arthritis/signs; Fatigue Tiredness in Elderly; Listlessness/lassitude; Dry eyes/poor tearing; Dry eyes/Poor tearing in Children; Dry eyes/Poor tearing in Elderly; Dryness Conjunctiva; Grainy/Gritty Eye Sensation; Calcification/pinna cartilage/sign
Typical Clinical Presentation: Arthritis with Subcutaneous/Skin Nodules; Presentation/Fatigue, Arthritis, Loss Libido
Clinical Presentation & Variations: Presentation/Congestive heart failure Child; Presentation/Diabetic Decreased need for Insulin; Presentation/Liver Pancreas Heart Endocrine Involvement; Presentation/Pancreatitis Kids Recurrent; Presentation/Aggressive Osteoarthritis; Presentation/Osteoarthritis Knuckle Joints Agressive (Index Long)

Demographics & Risk Factors
Ethnic or Racial Factors: Population Caucasian/White
Established Disease Population: Patient/Hemochromatosis
Population Group: Child; Population/Pediatrics population
Family History: Family history/Diabetes mellitus; Family history/Endocrine disorder; Family history/Liver disease; Family history/Arthritis
Sex & Age Groups: Population/Child; Population/Children/all

Laboratory Tests
Abnormal Lab Findings (Non Measured): Chromosomal abnormality (Lab); DNATest specific/genetics laboratory/abnormality (Lab); Ferritin extremely high (Lab); Gene mutation C282Y Test Positive; Gene mutation H63D Test Positive; Hepatic Enzymes Abnormal (Lab); HFE Gene mutations; HFE mutation (C282Y or H63D) positive (Lab); Liver Functions Abnormal (Lab); Transaminase elevation (Lab); HLA A3 (Lab); HLA B27 (Lab)
Abnormal Lab Findings - Decreased: ACTH/Corticotrpin/Adrenocortical Hypertrophic hormone (Lab); Androgens (Lab); Ascorbic acid/Vitamin C (Lab); Cortisol (Lab); Growth hormone/STH, plasma (Lab); LH/Leutinizing Hormone (Lab); Testosterone Total (Lab); TIBC/Total Iron Binding capacity (Lab); Transferrin (Lab); Transferrin receptor index; Uric acid, serum (Lab); URINE 17-Ketosteroids
Abnormal Lab Findings - Increased: Alkaline phosphatase, liver isoenzyme/serum (Lab); Alkaline phosphatase, serum (Lab); ALT (SGPT) (Alanine transferase) (Lab); Ammonia blood (Lab); Aspartamine aminotransferase (SGOT, AST) (Lab); AST (SGOT) (aspartamine transferase) (Lab); Bilirubin, serum (Lab); Copper, serum (Lab); Ferritin, serum (Lab); FSH/Follicle Stmulating Hormone/ICSH (Lab); Gammaglutamyl transferase/GGT (Lab); Glucose, blood (Lab); Indirect bilirubin (Lab); Iron, serum (Lab); LAP/Leucine Amino Peptidase (Lab); Nucleotidase/5 (Lab); Potassium, serum (Lab); Saturated iron binding capacity (Lab); Transferrin (Lab); Transferrin saturation (Lab); URINE Growth hormone; URINE Hemosiderin

Diagnostic Test Results
Other Tests & Procedures: Heart cath/Left ventricle end-diastolic pressure inc; Gastroscopy/Esophageal varices
Pathology: PATH/Myocardial pathology/Fibrosis; Bone Marrow/Iron stores/increased; Bone Marrow/RES iron increased; BX/Hepatic Iron Index Abnormal; BX/Liver biopsy/Abnormal; BX/Liver biopsy/Diagnostic; BX/Liver biopsy/Increased liver iron stores; PATH/Pancreatic biopsy/Abnormal; BX/Synovial abnormal
Isotope Scan: MUGA Scan/Diastolic first derivative slow
EKG (ECG): EKG/Prolonged PR Interval (ECG); EKG/AV Nodal Block/Complete; EKG/Bifascicular hemiblock (ECG); EKG/Conduction defect findings (ECG); EKG/Changes/abnormalities (ECG)
CT Scan: MRI/Heart scan myocardial texture change; CT/Liver High Density/ABD; MRI/Ferriscan liver abnormal; MRI/Liver abnormal density; CT/Dexa-Scan Bone density Abnormal
X-RAY: Xray/Chest abnormal; Xray/Congestive heart failure signs/Chest; Xray/Large heart shadow/Chest; Xray/Abdominal calcifications/ABD; Xray/Abdominal film abnormalities/ABD/KUB; Xray/Liver calcification/ABD; Xray/Chest/Lung fields/Abnormal; Xray/Calcification of intervertebral disk; Xray/Chondrocalcinosis/knees; Xray/Joint abnormal; Xray/Joint cartilage calcification; Xray/Joint/cartilage erosion signs; Xray/Metacarpal Phalangeal Joint Erosion; Xray/Metacarpal-phalangeal hook-like osteophytes; Xray/Ossification/calcification lumbar disks/LS spine; Xray/Osteophytes; Xray/Subchondral cysts/Joint; Xray/Calcification ear cartilage/Skull
X-RAY With contrast: UGI/Esophageal varices
Ultrasound: Echo/Poor filling ventricles; Echo/Stiff ventricular wall motion; Ultrasound/Abdomen/Liver small

Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs: Addison's disease; Autoimmune hepatitis; Hemosiderosis; Hepatic vein thrombosis (Budd-Chiari); Non-alcoholic fatty liver disease; Osteoarthritis, degenerative; Polyglandular autoimmune syndrome; Portal hypertension; Chronic Hepatitis
Associated Disease & Complications - Causes: Addison's disease; Adrenocortical insufficiency; Anorchia/Hypoplasia testes; Arthritis; Arthropathy, destructive/erosive; AV node lesion/infiltrate; Bilirubinemia; Bradyarrhythmias; Capnocytophaga Canimorsus (CDC group DF2); Carcinoma, hepatocellular; Cardiac arrhythmias; Cardiac conduction defects; Cardiomyopathy; Cardiomyopathy, dilated; Cardiomyopathy, hemochromatosis; Cardiomyopathy, restrictive; Cardiomyopathy, secondary; CHF with Preserved Ejection Fraction; Cholelithiasis; Chondrocalcinosis, articular; Chronic hepatitis/Active; Cirrhosis; Cirrhosis/complication/secondary; Congestive heart failure; Diabetes mellitus; Endocrine dysfunction; Esophageal varices; Glucocorticoid Deficiency; Gynecomastia; Heart block, complete; Hemochromatosis; Hepatic encephalopathy; Hip arthritis; Hyperammonemia; Hyperglycemia; Hyperpigmentation; Hypogonadism, male; Hypoparathyroidism, primary; Hypoparathyroidism/secondary; Hypothyroidism (myxedema); Hypouricemia; Impotence/Erectile dysfunction disorder; Infertility/sterility, female; Infiltrative cardiomyopathy; Knee arthritis; Left Ventricular Failure; Listeria meningitis; Male osteoporosis syndrome; Metacarpal DJD/Second and Third Severe; Myocarditis, acute; Osteoarthritis in Young Adults; Osteoarthritis, degenerative; Osteoporosis/osteopenia; Pancreatitis, chronic/recurrent; Panhypopituitarism; Pathologic fractures; Peritoneal Effusion; Pituitary hypothyroidism; Pituitary ischemic necrosis; PolyArthritis in Elderly; Polyarthritis syndrome/Multiple joints/weeks; Portal hypertension; Pseudogout (CPPD) arthritis; Secondary female hypogonadism; Shoulder osteoarthritis; Supraventricular tachycardia; Synovitis/arthritis; Testicular atrophy; Vibriosis/non-cholera; Yersinia enterocolitis syndrome; Heart Failure in a Child; Iron Overload; Chronic Hepatitis; Diabetes mellitus/non-insulin dep/type II; Metabolic Bone Disease; Monoarthritis Acute; PolyArthritis

Disease Mechanism & Classification
Class: CLASS/Chronic liver disease (ex); CLASS/Second/third metacarpal phalangeal joint/manifestation; CLASS/Systemic/no comment (category)
Pathophysiology: Pathophysiology/Gene locus 6p21.3; Pathophysiology/Gene locus Chromosome 6; Pathophysiology/Gene locus Chromosome 6p; Pathophysiology/Gene Locus Identified/OMIM database; Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations); Pathophysiology/Hereditary disease/Adult manifestations; Pathophysiology/Homozygous for Disease; Pathophysiology/Multisystem disease; Pathophysiology/Single gene locus indentified; Pathophysiology/Cardiac Diastolic Compliance Decreased; Pathophysiology/Delayed Diastolic Relaxation; Pathophysiology/Diastolic left ventricular dysfunct/failure; Pathophysiology/Diastolic-type heart failure/poor filling; Pathophysiology/High end-diastolic pressures (ex); Pathophysiology/Inadequate ventricular diastolic filling; Pathophysiology/Myocardial infiltrate/Infiltrative (ex); Pathophysiology/Adrenal destruction/atrophy/infiltrate; Pathophysiology/Hypogonadotrophic hypogonadism; Pathophysiology/Primary Testicular Failure; Pathophysiology/HFE Gene mutation H63D; Pathophysiology/HFE gene mutation/C282Y mutation; Pathophysiology/Bleeding from Portal Veins; Pathophysiology/Osteoporosis Secondary
Process: PROCESS/Autosomal recessive disorder (ex); PROCESS/Enzyme defect/Metabolic disorder (ex); PROCESS/Ethnic predilection (ex); PROCESS/Hereditofamilial (category); PROCESS/Metabolic/storage disorder (category); PROCESS/Storage disorder (ex)

Synonyms
Synonym: Gene Mutation 565C Test Positive; MRI/Hyperdense Liver Black Appearing/ABD; Synonym/Bronze diabetes

Treatment
Drug Therapy - Contraindication: RX/Ascorbic acid/Vitamin C; RX/Iron/Ferrous Sulfate (Feosol)
Drug Therapy - Indication: RX/Chelating agent; RX/Deferasirox (Exjade); RX/Deferoxamine (Desferal)
Surgical Procedures or Treatments: SX/Biopsy; SX/Liver biopsy
Other Treatments: TX/Phlebotomy.

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