Disease Comparison Results (show all mode) for Cockayne syndrome and Progressive Supranuclear Palsy

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Progressive Supranuclear Palsy

Found: 162 | Differences: 153

Cockayne syndrome

Found: 155 | Differences: 146

Cockayne syndrome and Progressive Supranuclear Palsy sharing 9 common findings. (show all, show common, show differences)

Clinical Manifestations
Signs & Symptoms
Akinetic rigid frozen Posture
Vertical Diplopia
Facial muscle rigidity
Frontalis Overactivity
Mask-like facies
Staring Expression
Choking
Dysphagia Liquids
Dysphagia Swallowing Difficulties
Gagging
Regurgitation
Slow eating pattern
Unable to swallow
Drooling
Pharyngeal cordination problems
Muscle stiffness/rigidity
Retrocollis
Apathy/Indifference
Ataxia
Axial dystonia
Axial dystonia, progressive
Basal ganglion signs
Bradykinesia
Cognitive defect
Cognitive defects/multiple types
Cranial nerve abnormalities/involvement/signs
Difficulty concentrating/Distraction/Forgetful
Dysarthria
Dysconjugate gaze
Dystonia
Dystonia, acquired
Extrapyramidal signs
Facial weakness/droop, unilateral
Jaw jerk increased
Myoclonus/Myoclonic jerks on exam
Nasal speech/regurgitation
Near recall/memory deficit/defect
Nuchal dystonia
Odd body posturing
Passive stretch resistance increased
Postural lability/easy to push over
Rapidly progressive dementia
Retropulsion/propulsion gait
Slow speech
Speech Locution Problems
Staggering Gait
Unable to tandem walk/straight line
Vertical nystagmus
Depressed/discouraged/sad
Emotional Incontinence/Lability
Emotional/affective lability
Loss inhibition/Dysinhibition, social
Volatility/wild mood swings
Wry neck spasm
Difficulty speaking/phonating
Difficulty Talking
Frequent Gagging Choking Clearing throat
Garbled/nasal sounding voice
Nasal/Hyponasal sound to voice
Voice change/disturbance/Unusual
Falling
Difficulty Focusing Eyes
Diplopia Double vision
Double Image Vision Confirmed
Eye symptoms/signs
Infrequent blinking/Stellwag sign
Squint/sign
Upward gaze paralysis/sign
Upward gaze paralysis/voluntary
Vertical gaze problems
Visual symptoms
Weak lateral gaze
Disease Progression
Course/5-year progressive
Course/Chronic disorder
Course/Chronic only
Course/Progressive/slowly chronic illness
Parkinsonism plus Other CNS issues
Demographics & Risk Factors
Population Group
Aged Adult
Middle Age Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Elderly Aged
Population/Fifties adult
Population/Male
Population/Middle-aged adult
Population/Seventies Adult
Diagnostic Test Results
Pathology
PATH/Brain/Basal ganglion neuron degeneration
PATH/Brain/Brainstem neuron degeneration
PATH/Brain/Neurofibrillary tangles/cortex
PATH/Gliosis spinal cord
PATH/Gliosis/Brain/CNS
PATH/Hyperphosphorylated Tau microtubule deposits
Pathophysiology/Tauopathy (Tau positive deposits) CNS
CT Scan
MRI/Head Dorsal Midbrain Atrophy
MRI/Head Scan Abnormal
PET Scan/Head abnormal
X-RAY With contrast
UGI/Esophagus motility disorder
UGI/Hypopharynx/pooled barium vallecula
Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs
Cerebellar ataxia
Cerebellar vermis lesion
Corticobasal neurodegenerative syndrome
Dementia, Lewy body type
Lacunar/multiple lacunar/basal gangion/CVA
Normal pressure hydrocephalus
Parkinsonism, secondary
Parkinsonism-dementia complex
Parkinsons disease
Shy-Drager syndrome
Associated Disease & Complications - Causes
Anxiety
Aspiration
Blepharospasm
Dementia
Dementia, terminal
Depression
Esotropia
Extrapyramidal disease/manifestation
Ophthalmoplegia
Ophthalmoplegia/progressive/ext/chronic
Parkinsonism, secondary
Parkinsons disease
Pneumonia, aspiration
Pneumonia, recurrent
Pneumonia/Bronchopneumonia
Progressive Supranuclear Palsy
Pseudobulbar palsy syndrome
Supranuclear ophthalmoplegia
Akinetic Rigid Syndrome
Ataxia Disorder
Parinaud's Ophthalmoplegia
Disease Mechanism & Classification
Class
CLASS/Primary organ/system disorder (ex)
CLASS/Basal ganglia lesion/involvement/disorders (ex)
CLASS/Brain stem involvement/disorder (ex)
CLASS/Brain/CNS disorder (ex)
CLASS/Cerebellar disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Gene locus 17q21.1
Pathophysiology/Gene locus Chromosome 17
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Pharyngeal muscle weakness, spastic
Pathophysiology/Brain stem/basal ganglion lesions
Pathophysiology/Midbrain/mesencephalon lesion
Pathophysiology/Eye movement problems
Process
PROCESS/Idiopathic/unclassified/unknown (category)
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Use/Age/atrophic disorder (category)
Synonyms
Synonym
Synonym/Nuchal dystonia dementia syndrome
Synonym/Progressive pseudobulbar palsy
Synonym/PSP syndrome
Synonym/Steele-Richardson-Olszewski syndrome
Synonym/Supranuclear palsy, progressive
Synonym/Supranuclear palsy/degeneration
Treatment
Drug Therapy
RX/Amantadine (Symmetrel)
RX/Bromocriptine (Parlodel)
RX/Levodopa (Dopar)
Other Treatments
TX/Physical therapy
TX/Speech Therapy
Clinical Manifestations
Signs & Symptoms
Particular physiognomy/Odd looking kids
Craniofacial Abnormalities/Congenital
Facial loss of adipose tissue
Facies particular
Facies/Bird like
Loss fatty deposits/facial area
Pinched/thin nose
Sun exposed areas/face, arms/involved
Acrocyanosis/Cyanosis extremities
Child/Extremities cold/pale often cyanosed
Gray Hair
Gray hair Childhood
Gray hair, premature
Hyperpigmented patches/sun exposed areas
Increased pigmentation/tanning/hyperpigmented
Mutilating/skin lesions/light exposed areas/face
Patchy pigmentation/face/neck/hands
Photosensitivity/Sunsensitive skin
Scaling/Skin finding
Silvery gray hair/child
Skin atrophy/Poikiloderma
Sunburns too easily
Telangiectasias in Children
Telangiectasias, skin
Thin hyperpigmented skin/facial
White Hair
Anorexia in Infant
Failure to Thrive
Failure to Thrive Child
Failure to thrive/infant sign
Feeding/Apetite Problems Child
Carious teeth/child
Carious teeth/sign
Large/protruding jaw/prognathism
Teeth malformed/dysplastic
Palpable Liver/Hepatomegaly
Cold hands/fingers and toes
Distal Muscle Weakness
Long legs
Ataxia
Equinus Posture/Ankles
Gait disturbance/abnormality
Idiocy/signs
Intellectual Decline Children
Mental Deficiency Child
Mental/motor retardation in children/signs
Movement or gait disorder/signs
Progressive neurological disorder/signs
Spasticity/Spastic gait
Staggering Gait
Tremor
Tremor in Children
Tremor,coarse
Barrel chest/Increased AP diameter
Psychomotor retardation
Dysmorphic dwarfism/short stature
Head size/circumference small/sign
Odd sounding voice/husky
Voice change/disturbance/Unusual
Dysmorphic appearance/face
Premature Aging
Short stature
Short stature Child
Dry eyes/poor tearing
Dry eyes/Poor tearing in Children
Dryness Conjunctiva
Grainy/Gritty Eye Sensation
Anomalous ears/deformities
Big ears
Prominent Ears
Protruberant/lop ears
Typical Clinical Presentation
Presentation/Normal infant/Severe hereditary disease
Presentation/Coronary Heart Disease Young Age
Clinical Presentation & Variations
Presentation/Multiple deformities newborn (odd look)
Presentation/Arteriosclerosis Young Age
Presentation/Myocardial Infarction in a Child
Presentation/Growth Mental Development Slow 18 months
Presentation/Mental Retardation Progressive
Presentation/Juvenile Cataract
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Life-span decreased
Course/Prognosis bad/usually
Course/Progressive
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Family History
Family history/Dwarfism
Family history/Skeletal malformations
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Diagnostic Test Results
Pathology
PATH/Brain/Sudanophilic myelin dystrophy/leukodystrophy
PATH/Brain/White matter/deficient myelin
CT Scan
CT Scan/Head Calcified Basal ganglia
MRI/Head Demyelination white matter
X-RAY
Xray/Basal ganglia calcification/Skull
Xray/Calcifications intracranial/brain/Skull
Xray/Multiple intracranial calcifications/Head
Xray/Skull bones thickened
Xray/Terminal phalanges/ivory dense metaphysis
Xray/Vertebrae long/bicovex abnormality
Xray/Wide phalanges
Associated Diseases & Rule outs
Associated Disease & Complications - Rule Outs
Ataxia-telangiectasia
Myocardial infarction, acute
Progeria
Associated Disease & Complications - Causes
Arteriosclerosis
Arteriosclerosis, lower extremities
Arteriosclerotic heart disease
Blindness
Cataract
Cockayne syndrome
Deafness
Deafness, congenital
Deafness, sensorineural
Dental caries
Dental deformities/anomalies
Dwarfism
Hereditary Blindness
Hyperpigmentation
Joint contractures
Kyphoscoliosis
Kyphosis
Mental retardation
Microcephaly/oligophrenia
Nanism/dwarfism
Neurodevelopmental disorders
Photosensitivity dermatitis
Phototoxicity
Premature aging/senescence
Retinal atrophy
Retinitis pigmentosa
Teeth enamel hypoplastic
Telangiectasia
Vertebrae Anomalies
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Systemic/no comment (category)
Pathophysiology
Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis
Pathophysiology
Pathophysiology/DNA transcriptase repair defect
Pathophysiology/Gene locus Chromosome 5
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Process
PROCESS/Autosomal recessive disorder (ex)
PROCESS/Congenital/developmental (category)
PROCESS/Eponymic (category)
PROCESS/Hereditofamilial (category)
PROCESS/Multiple dysmorphic syndrome (ex)
PROCESS/Dystostosis/craniofacial (ex)
PROCESS/Vertebral anomalous congenital syndrome
Synonyms
Synonym
Early Onset Ataxia/Children
Synonym/CAMFAK (Cataract-microcephaly-failure to thrive-kyphosis) Var
Synonym/Lowry syndrome
Treatment
Other Treatments
TX/Expectant/supportive treatment.
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