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Disease Comparison Results (show differences mode) for Cirrhosis/childhood Indian type and Familial Cold Autoinflammatory syndrome/FCAS (1q44).

Clinical
Demographics
Lab
Diagnostic
Diseases
Classification
Synonyms
Treatment
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Familial Cold Autoinflammatory syndrome/FCAS (1q44).

Found: 57 | Differences: 54

Found: 146 | Differences: 143

Cirrhosis/childhood Indian type and Familial Cold Autoinflammatory syndrome/FCAS (1q44). sharing 3 common findings. (show all, show common, show differences)

Clinical Manifestations
Signs & Symptoms: Cold urticaria; Ice Cube test/Urticaria Abnormal; Rash; Excess Thirst in Children; Arthritis Children; Cold intolerance; Cyclic Periodic Recurrent Fevers; Periodic fever; Bloodshot eyes/Conjunctival injection; Eye Pains, Bilateral; Red Eyes Bilateral; Scleral Injection
Disease Progression: Course/Periodic Episodic; Onset childhood/young adult/twenties

Laboratory Tests
Microbiology & Serology Findings: Stool Microscopic polys present
Abnormal Lab Findings (Non Measured): Acute phase reactants increased (Lab)
Abnormal Lab Findings: WBC; Amyloid A serum (Lab); C-reactive protein (Lab); Interleukin 1 (IL-1) levels (Lab); Interleukin-6 IL-6 Serum (Lab); Serum Amyloid A (SSA); WBC/White Blood Cell Count/Leukocytes (Lab)

Associated Diseases & Rule outs
Associated Disease & Complications: Amyloidosis, renal; Amyloidosis, systemic; Arthritis; Conjunctivitis; Deafness; Deafness, sensorineural; Familial Cold Autoinflammatory syndrome/FCAS (1q44).; Polyarthritis in Children; Polyarthritis syndrome/Multiple joints/weeks; Urticaria, cold/immersion; Urticaria/hives; PolyArthritis

Disease Mechanism & Classification
Pathophysiology: Pathophysiology/Autoinflammatory (non-immune); Pathophysiology/Gene locus 1q44; Pathophysiology/Gene locus Chromosome 1; Pathophysiology/Gene Locus Identified/OMIM database; Pathophysiology/Maternal Chromosome mutation; Pathophysiology/Auto-Inflammatory Disorder; Pathophysiology/Excess Interleukin I (IL-1) produced; Pathophysiology/CIAS1 Gene mutation; Pathophysiology/CIAS1/NLRP-3 Gene Mutation
Process: PROCESS/Autosomal dominant hereditary disease (ex).; PROCESS/Genetic disorder/Spontaneous mutations/sporadic; PROCESS/INCIDENCE/Esoteric disease (example); PROCESS/INCIDENCE/Extremely rare disease

Synonyms
Synonym: Synonym/FCAS; Synonym/Muckles Wells Syndrome/FCAS (1q44)

Treatment
Drug Therapy: RX/Canakinumab (Llaris); RX/Rilonacept IL-1 Blocker (Arcalyst)

Clinical Manifestations
Signs & Symptoms: Edema Children; Bilateral ankle swelling; Bilateral leg edema/swelling; Clubbing; Clubbing of fingers/toes; Bruising/Ecchymosis; Prominent venous plexus/cutaneous; Spider nevi/angiomata/Abdominal sign; Telangiectasias in Children; Yellow skin discoloration; Excessive/easy bruising tendency; Anorexia Decreased appetite; Caput medusa/abdomen; Signs of ascites; Chest/truncal venous distension; Fever with Jaundice; Jaundice of newborn; Jaundice/Yellow skin and eyes; Liver firm/edge indurated; Liver palms/erythema; Palpable Liver/Hepatomegaly; Yellow eyeballs/Scleral icterus; Edema of Lower Extremities; Palmar Erythema/Redness; Epistaxis Children; Dark urine; Chronically ill patient/signs; Debilitated; Fatigue Tiredness in Children; Fever; Fever Febrile Possible; Flu-Like Syndrome; High body temperature; Short stature Child
Typical Clinical Presentation: Presentation/Painless/jaundice
Clinical Presentation & Variations: Presentation/Cirrhosis Non-Alcoholic
Disease Progression: Course/Chronic disorder; Course/Lethal; Course/Prognosis bad/usually; Course/Progressive; Course/Relentless; Course/Severe illness; Course/Subacute; Onset ages 2 to 3 yrs; Onset/Childhood

Demographics & Risk Factors
Exposure Factors: Exposure/Epidemiologic specific setting/exposure; Exposure/Use/Copper cooking/storage vessels
Travel, Geographic & Climate Related Factors: Residence/travel/Africa; Residence/travel/Central America; Residence/travel/Middle East; Residence/travel/Rural area
Ethnic or Racial Factors: African black population; Asian Indian population; Egyptian population; Middle Eastern Population
Population Group: Child; Population/Immigrant population; Population/Pediatrics population
Family History: Family history/Liver disease; Family history/Liver disease Children
Sex & Age Groups: Population/Child; Population/Child-Infant Only; Population/Children/all

Laboratory Tests
Abnormal Lab Findings (Non Measured): ASCITIC Transudates (Ex); Acute inflammatory markers elevated (Lab); Fasting hypoglycemia (Lab); Hepatic Enzymes Abnormal (Lab); Immunelectrophoresis polyclonal globulin (Lab); Liver Functions Abnormal (Lab); Protein electrophoresis/Beta-Gamma Peaks Serum); SAAG Serum Ascites-albumin gradient/high (Lab); Transaminase elevation (Lab)
Abnormal Lab Findings - Decreased: Albumin, serum (Lab); ASCITIC Protein
Abnormal Lab Findings - Increased: Alkaline phosphatase, liver isoenzyme/serum (Lab); Alkaline phosphatase, serum (Lab); ALT (SGPT) (Alanine transferase) (Lab); Ammonia blood (Lab); Aspartamine aminotransferase (SGOT, AST) (Lab); AST (SGOT) (aspartamine transferase) (Lab); Bilirubin, serum (Lab); Copper, serum (Lab); Estradiol Serum (Lab); Gamma globulin (Lab); Globulin, serum (Lab); IGG/Immunoglobulin G (Lab); URINE Estrogens; URINE/Estradiol (Lab); URINE/Estratriol (Lab)

Diagnostic Test Results
Other Tests & Procedures: Gastroscopy/Esophageal varices; Paracentesis/Abnormality
Pathology: BX/Liver biopsy/Abnormal; BX/Liver biopsy/Copper deposit/tissue; BX/Liver biopsy/Mallory bodies
CT Scan: CT Scan/Ascites signs; CT Scan/Liver abnormality; CT Scan/Liver Caudate/Right lobe size ratio >.65; CT Scan/Liver Portasystemic venous collaterals; CT Scan/Liver Right lobe/atrophy/Left/caudate enlarged; CT Scan/Spleen enlarged
X-RAY: Xray/Peritoneal fluid/child/ABD
X-RAY With contrast: UGI/Esophageal varices
Ultrasound: Ultrasound/Abdomen/Liver small; Ultrasound/Spleen enlarged

Associated Diseases & Rule outs
Associated Disease & Complications: Ascites; Ascites in Children; Bilirubinemia; Bleeding esophageal varices; Cirrhosis; Cirrhosis in childhood; Cirrhosis, childhood/Indian type; Edema; Epistaxis/nosebleed; Esophageal varices; Hepatic failure; Hyperammonemia; Hyperglobulinemia; Hypoalbuminemia Hypoproteinemia; Peritoneal Effusion; Portal hypertension; Telangiectasia; Upper GI Bleeding in children

Disease Mechanism & Classification
Class: CLASS/Hepatic architecture disorder (ex); CLASS/Liver involvement/disorder (ex)
Pathophysiology: Pathophysiology/Copper accumulation/tissues; Pathophysiology/Bleeding from Portal Veins; Pathophysiology/Hepatic manifestations/involvement
Process: PROCESS/Copper/metabolism disorders (ex); PROCESS/Hereditary/Genetic predisposition (ex); PROCESS/INCIDENCE/Regional specific; PROCESS/Poisoned organ/system (category)

Treatment
Drug Therapy: RX/Penicillamine (Cupramine); RX/Trientine (Syprine/Cuprid)
Surgical Procedures or Treatments: SX/Biopsy; SX/Liver biopsy; SX/Liver transplant

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