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Differential Diagnosis For Pemberton's Sign


List of current finding(s):

Infected organ, Abscesses
Neck space infection/Ludwig's angina
Neoplastic Disorders
Mediastinal tumor
Mediastinum, lymphosarcoma/lymphoma
Pancoast tumor/syndrome
Anatomic, Foreign Body, Structural Disorders
Neck compartment hemorrhage/hematoma
Mediastinal mass
Superior vena cava syndrome
Primary thrombosis superior vena cava
Thoracic Inlet Obstruction Physiology
Arteriosclerotic, Vascular, Venous Disorders
Aneurysm, thoracic aorta
Reference to Organ System
Mediastinal adenopathy
Multinodular colloid adenomatous goiter
Goiter, substernal

Described with substernal goiter with obstruction on inlet of neck and, argely vascular venous return problems with neck certain maneuvers; seen also with upper mediastinal masses and apical lung tumors as well as thoracic aortic aneurysm. This is manifest with arms held upward close to the head on either side and observing plethora of the face and disended neck and scalp veins. Next comes cyanosis regionally with distress worsened by valsalva maneuver.

Also known as Pemberton's maneuver as an endocrine disease sign.


External Links Related to Pemberton's Sign
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)