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Differential Diagnosis For Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab) - Increased
List of current finding(s):
Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab) - Increased
- Granulomatous, Inflammatory Disorders
- Wegeners granulomatosis
- Wegener's pulmonary (isolated) disease
- Allergic, Collagen, Auto-Immune Disorders
- Polyarteritis nodosa
- Rheumatoid arteritis/vasculitis
- Vasculitis
- Polyarteritis nodosa, infantile
- Microscopic Polyangiitis/PAN variant
- Drugs
- Propylthiouracil (PTU) Administration/Toxicity
- Thiouracils (PTU/Tapazol) Administration/Toxicity
- Drug Induced vasculitis
- Synonyms
- Lab, Myeloperoxidase antibody assay, Myeloperoxidase antibody assay (procedure), Myeloperoxidase antibody test
- Definition
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Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
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- External Links Related to Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab) - Increased
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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