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Differential Diagnosis For Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab) - Increased

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List of current finding(s):

Granulomatous, Inflammatory Disorders
Wegeners granulomatosis
Wegener's pulmonary (isolated) disease
Allergic, Collagen, Auto-Immune Disorders
Polyarteritis nodosa
Rheumatoid arteritis/vasculitis
Vasculitis
Polyarteritis nodosa, infantile
Microscopic Polyangiitis/PAN variant
Drugs
Propylthiouracil (PTU) Administration/Toxicity
Thiouracils (PTU/Tapazol) Administration/Toxicity
Drug Induced vasculitis
Synonyms
Lab, Myeloperoxidase antibody assay, Myeloperoxidase antibody assay (procedure), Myeloperoxidase antibody test
Definition

Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.

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External Links Related to Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab) - Increased
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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