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Edit definition for Job syndrome (Hyper IgE syndrome)

Job Syndrome;  HIE Syndrome; Hyper-IgE Syndrome; Hyperimmunoglobulin E Syndrome;  Hyperimmunoglobulin E-Recurrent Infection Syndrome; Hyperimmunoglobulinemia E-Staphylococcal; Job-Buckley Syndrome; Job Syndrome is an immunodeficiency syndrome characterized by recurrent bacterial (staphylococcal) infections, particularly of the skin, and markedly elevated IgE [Immunoglobulin E] levels; some autosomal dominant inheritance; Staphylococcal furuncles may involve the skin, lungs, joints and other sites; Some patients have coarse features; some are fair and redheaded; Decreased bone density and frequent fractures are common; Some dysfunctional neutrophils; Signs of allergy such as eczema, asthma and/or runny noses often; Treatment consists of intermittent or continuous antibiotics; Sexes are about equal frequency--------(NORD 2005)------------------------<br>
Features include: coarse facies; lung infections;<br>
skin infections; cold abscesses, which may affect bone and skin with staph as well as candida--------[gpnotebook website 2005]----------------

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